Factores de riesgo para páncreas hiperecogénico en ecoendoscopía: estudio de casos y controles

Identificar con ecoendoscopía (EE) páncreas hiperecogénico y determinar factores de riesgo para el mismo en una muestra de pacientes evaluados entre Junio 2005-Mayo 2010. Material y métodos: Estudio de casos y controles, retrospectivo, en una población de 5495 pacientes evaluados, de los cuales se seleccionaron 989 como casos (con un aumento de ecogenicidad parcial o global del páncreas) y 642 controles (con ecopatrón pancreático normal). Se compararon variables demográficas, clínicas y ecoendoscópicas entre ambos grupos de estudios y se calcularon OR y sus correspondiente IC95% después de realizar análisis bivariado y multivariado de los factores de riesgo. Resultados: En la población evaluada, los factores de riesgo identificados con mayor fuerza de asociación en el análisis multivariado fueron esteatosis hepática (OR=29,581; IC95% 17,942-48,770), hepatopatía mixta (OR=10,724; IC95% 1,634-70,378), hipotiroidismo (OR=8,381; IC95% 2,067-33,977) y tabaquismo (OR=2,790; IC95% 1,036-7,515). Otros factores asociados en menor magnitud fueron: hepatopatía crónica, antecedentes familiares de diabetes mellitus e hipertensión arterial, edad e índice de masa corporal. Conclusiones: Existen escasos estudios que hayan identificado factores de riesgo para esteatosis pancreática empleando EE. Los hallazgos encontrados concuerdan con lo reportado recientemente en otros estudios internacionales donde la esteatosis hepática fue el predictor de mayor fuerza para encontrar en la EE páncreas hiperecogénico (OR=29). Sin embargo, el presente estudio encontró una asociación dos veces mayor a la previamente reportada. En adición a ello se observa claramente que en el presente estudio existen múltiples factores asociados al hallazgo de páncreas hiperecogénico que deben ser tomados en cuenta.To identify through ecoendoscopy (EE) hyperecogenic pancreas and to determinate risk factors for it in a sample of patients evaluated between June 2005 and May 2010. Material and methods: Cases and controls study, retrospective observational study, in a population of 5,495 patients; from them 989 were selected as cases (with an increase of partial or global ecogenicity of the pancreas) and 642 controls (with a normal pancreatic ecopattern). Demographical, clinical and ecoendoscopical variables from both groups were compared; OR were calculated with their 95%CI, after bivariate and multivariate risk factors analyses. Results: In the studied population, identified risk factors, mostly associated at the multivariate analyses, included: liver steatosis (OR=29.581; 95%CI 17.942-48.770), mixed hepatopathy (OR=10.724; 95%CI 1.63470.378), hypothyroidism (OR=8.381; 95%CI 2.067-33.977) and smoking (OR=2.790; 95%CI 1.036-7.515). Other factors were: chronic hepatopathy, family history of diabetes mellitus and high blood pressure, age and body mass index. Conclusions: There are few studies regard the identification of risk factors for pancreatic steatosis using EE. Current findings are similar with others recently reported in other countries, where liver steatosis is a predictor to find hyperecogenic pancreas at the EE (OR=29). However, this study found an association two-fold higher than that previously reported. In addition, is clear that in this study there are multiple factors associated with the finding of hyperecogenic pancreas that should be considered

Curriculum for diagnostic endoscopic ultrasound training in Europe : European Society of Gastrointestinal Endoscopy (ESGE) Position Statement

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Uso de la Tractografía con Tensor de Difusión como Complemento en el Diagnóstico y Apoyo en el Tratamiento Oportuno de la Mielopatía Cervical Degenerative

Cervical degenerative myelopathy is a chronic, progressive disease. It is a dysfunction of the spinal. Cord that can commonly be caused by a number of conditions, including deterioration of the osteocartilaginous components of the cervical spine, which is often related to aging. Diagnosis is clinical and by cabinet imaging. Diffusion tensor tractography, being a non-invasive technique, is considered an adjunct to the T2 sequence, which reveals spinal cord deterioration in people with early stage cervical spondylosis before those changes were visible on conventional magnetic resonance imaging, thus improving clinical outcome and patient management. The therapeutic options that currently exist appear to produce an improvement in neurological function in those with progressive disease or intolerable symptoms.La mielopatía degenerativa cervical es una enfermedad crónica y progresiva. Es una disfunción de la columna. Cordón que comúnmente puede ser causado por una serie de afecciones, incluido el deterioro de los componentes osteocartilaginosos de la columna cervical, que a menudo está relacionado con el envejecimiento. El diagnóstico es clínico y por imágenes de gabinete. La tractografía con tensor de difusión, al ser una técnica no invasiva, se considera un complemento de la secuencia T2, que revela el deterioro de la médula espinal en personas con espondilosis cervical en etapa temprana antes de que esos cambios fueran visibles en la resonancia magnética convencional, mejorando así el resultado clínico y el manejo del paciente. . Las opciones terapéuticas que existen actualmente parecen producir una mejora en la función neurológica en aquellos con enfermedad progresiva o síntomas intolerables

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

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MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe