History of Cities in Western Siberia in Representations of Journal “Siberian Lights”: Political and Historical Contexts of 1920s — 1940s

Changes in the representation of the history of cities in Western Siberia in the journal “Siberian Lights” in the period from the beginning of the 20s to the mid 40s of the XX century are considered. These changes are interpreted by analyzing the general contexts of the development of historical local lore in Siberia and the activities of various subjects of the memory policy at both local and state levels. The relevance of the study is due to the increased interest on the part of society and the state in the problems of forming the historical memory of Russians about the national and regional past as one of the foundations of social identities. The novelty of the research is seen in the fact that until now the Siberian magazine periodicals of the Soviet era, in particular, “Siberian Lights”, are poorly understood as one of the significant means of forming the historical memory of society about the past of Western Siberia. The composition of the authors of materials on the history of Western Siberian cities is described in the article. The stages of the development of the history representation of West Siberian cities in the publications of the journal are determined, reflecting various, ideologically determined assessments of the historical past of the cities of Western Siberia. It is proved that during the Great Patriotic War, authors of works on the history of Western Siberian cities synthesized both the experience of Siberian ethnographers and their antagonists, pursuing the task of stimulating patriotic upsurge and the necessary social mobilization

Politics of memory: historical symbols and commemorative practices in the system of socio-political selfregulation of the region (Siberia of the XX – early XXI centuries)

The purpose of this article is to generalize the dynamics of developing politics of memory, which was reflected in the processes of socio-political self-regulation of the Siberian region during the XX in the early XXI centuries. The study solves the problem of identifying the basic institutionalized forms and methods of using historical symbols within the framework of public commemorative practices and typical historical narratives, being established in Siberia in the XX beginning of the XXI centuries. The tasks also include identifying the stages of history of diverse manifestations of politics of memory in the memorial culture of Siberia in this period. The relevance of this article is due to the need of studying the meaning and methods of using historical symbols and commemorations within the framework of the politics of memory in order to form a critical, scientifically based position in relation to it. The study was implemented within the framework of the Memory Studies problem field and relies on interdisciplinary, sociocultural and socio-constructivist approaches. Comparative, diachronic, and systemic genetic methods there were used. For the first time the authors of the project intend to consider the politics of memory in relation to Siberia as a system that has gradually been formed and transformed depending on various conditions and factors. The scientific significance of the project is that the politics of memory implemented in the region by means of historical symbols and commemorative practices will be studied as a complex sociocultural phenomenon of regulating social consciousness of the regional society. As a result of the project implementation, the dynamics of using historical symbols and commemorations by various actors of regional politics in the sphere of building relations with central authorities and internal regional socio-political self-regulation processes. The authors define the stages of history of diverse manifestations of the memory policy in the memorial culture of Siberia. The Siberian macro-region, in spite of certain ethnocultural features in the areas where local peoples are densely populated, has emerged as one of the most Russian-oriented in its culture and dominant socio-political identity. And the basis of this result was the aggregate symbolic self-regulation of the Siberian society, which includes the dialectically complementary national and regional levels of memory policy

Barrier-Restoring Therapies in Atopic Dermatitis: Current Approaches and Future Perspectives

Atopic dermatitis is a multifactorial, chronic relapsing, inflammatory disease, characterized by xerosis, eczematous lesions, and pruritus. The latter usually leads to an “itch-scratch” cycle that may compromise the epidermal barrier. Skin barrier abnormalities in atopic dermatitis may result from mutations in the gene encoding for filaggrin, which plays an important role in the formation of cornified cytosol. Barrier abnormalities render the skin more permeable to irritants, allergens, and microorganisms. Treatment of atopic dermatitis must be directed to control the itching, suppress the inflammation, and restore the skin barrier. Emollients, both creams and ointments, improve the barrier function of stratum corneum by providing it with water and lipids. Studies on atopic dermatitis and barrier repair treatment show that adequate lipid replacement therapy reduces the inflammation and restores epidermal function. Efforts directed to develop immunomodulators that interfere with cytokine-induced skin barrier dysfunction, provide a promising strategy for treatment of atopic dermatitis. Moreover, an impressive proliferation of more than 80 clinical studies focusing on topical treatments in atopic dermatitis led to growing expectations for better therapies

Publications of Altai Fairy Tales and Heroic Legends in Context of Construction of 1920—1980s Soviet Politics of Memory

The issue of Altai fairy tales and heroic legends in the context of the 1920—1980s Soviet politics of memory is considered. Attention is paid to the participation of carriers of folklore traditions, folklorists, translators, writers, poets and editors in the creation of collections of Altai fairy tales. The specificity of their activities at different historical stages is characterized. The relevance of the study is due to the growing scientific and public interest in oral folk art in connection with the formation and development of the cultural memory of the peoples of Russia as the basis of social identities. The novelty of the research is seen in the fact that the publication of editions of Altai folk tales and heroic legends, collected, processed and published in Soviet times, is considered as a means of forming the cultural memory of Altai and other peoples of our country about the historical past of Altai Mountains. The authors note that Altai fairy tales, the publications of which have experienced a serious impact of the state politics of memory, have become the property of book culture rather than a living tradition of oral folk art. It is shown that in the late Soviet and early post-Soviet periods, book editions of fairy tales in the mass consciousness began to be perceived as a significant source for the interpretation of the historical past of the Altai ethnos

How payment for research participation can be coercive

The idea that payment for research participation can be coercive appears widespread among research ethics committee members, researchers, and regulatory bodies. Yet analysis of the concept of coercion by philosophers and bioethicists has mostly concluded that payment does not coerce, because coercion necessarily involves threats, not offers. In this article we aim to resolve this disagreement by distinguishing between two distinct but overlapping concepts of coercion. Consent- undermining coercion marks out certain actions as impermissible and certain agreements as unenforceable. By contrast, coercion as subjection indicates a way in which someone’s interests can be partially set back in virtue of being subject to another’s foreign will. While offers of payment do not normally constitute consent-undermining coercion, they do sometimes constitute coercion as subjection. We offer an analysis of coercion as subjection and propose three possible practical responses to worries about the coerciveness of payment

Изучение противопаркинсонического, противовоспалительного и анальгетического действия метаболита гимантана АДК-1058 в сравнении с гимантаном

Antiparkinsonian, anti-inflammatory and analgesic activity of ADK-1058, a metabolite of hemantane, was investigated in comparison with hemantane at the effective dose of 20 mg/kg. ADK-1058 exhibits a minor antiparkinsonian effect by reducing the severity of oLigokinesia in C57BL/6 mice with MPTP-induced parkinsonian syndrome. ADK-1058 exhibits anti-inflammatory activity in the model of acetic acid peritonitis, but has no analgesic effect in visceral or somatic pain in mice. Effects of ADK-1058 at the dose of 20 mg/kg do not exceed antiparkinsonian, anti-inflammatory or analgesic effects of hemantane at the dose of 20 mg/kg.В сравнительном аспекте проведено изучение противопаркинсонического, противовоспалительного и противоболевого действия метаболита гимантана АДК-1058 и гимантана в эффективной дозе 20 мг/кг. АДК-1058 проявляет слабую противопаркинсоническую активность, снижая выраженность олигокинезии у мышей С57B1/6 с МФТП-вызванным паркинсоническим синдромом. АДК-1058 проявляет противовоспалительную активность на модели уксуснокислого перитонита, но не оказывает анальгетического действия в отношении висцеральной и соматической боли. Метаболит гимантана АДК-1058 (20 мг/кг) по противопаркинсоническому, противовоспалительному и противоболевому действию не превосходит соответствующую активность гимантана (20 мг/кг)