Musculoskeletal disorders in hemodialysis patients: prevalence, clinical symptoms, and associated factors

Introduction: One of the major public health problems is end-stage renal disease (ESRD). ESRD is commonly associated with musculoskeletal disorders (MSDs). Objectives: Due to the importance of MSDs in hemodialysis patients and the absence of sufficient studies in Iran, this study aims to investigate MSDs in hemodialysis patients. Patients and Methods: This cross-sectional study was conducted on 75 patients with ESRD, who were under hemodialysis at the special diseases center of Birjand university of medical sciences, south Khorasan, Iran. Inclusion criteria were history of at least 2 years of hemodialysis, and age more than 18 years. All patients with previous neurological disorders, previous rheumatic diseases, previous arthroplasty of the limbs, and severe psychological disorders were excluded from the study. Baseline characteristics and laboratory data collected. MSDs examined based on the Nordic Musculoskeletal Screening Questionnaire (NMQ). Data were described using central tendency, CHI-SQUARE test, and Fisher’s exact test were used. The significance level in this study was P0.05). Dialysis etiology, knee osteoarthritis, shins pain, knee pain and knee range of motion had significantly difference between groups (respectively, P=0.047, P=0.003, P=0.012, P=0.001, P=0.002). Conclusion: The frequency of MSDs in these patients was 84.0%. There was a significant association between MSDs with the cause of hemodialysis, lower limb pain, and knee osteoarthritis

Comparison of serum levels of vitamin D in periodontitis patients with and without type 2 diabetes and healthy subjects

Abstract Objective The purpose of this study is to find out the levels of serum vitamin D in periodontitis patients with and without type 2 diabetes and to compare them with healthy subjects. Methods In this study, 48 periodontitis patients with type 2 diabetes mellitus (PDM), 53 periodontitis patients (P), and 42 controls who were in the age ranges of 30–50 years and had the entry requirements were selected. Plaque index, calculus index, modified gingival index, pocket depth, clinical attachment loss (CAL), and tooth loss were measured. Serum 25(OH)D level was estimated by electrochemiluminescence immunoassay, and fasting blood sugar and glycosylated hemoglobin were estimated by biochemical colorimetric assays. Results The mean serum 25(OH)D level was 17.06 ± 10.73, 15.12 ± 7.74, and 14.17 ± 11.04 ηg/ml for PDM, P, and control groups, respectively, showing no statistical difference. The mean CAL was significantly high in diabetic patients as compared to other groups. Prediabetes prevalence was significantly high in periodontitis patients as compared to controls. Conclusions The prevalence of vitamin D insufficiency was high in the population studied. Serum levels of 25(OH)D showed no significant difference between groups. Periodontitis patients showed an elevated risk for diabetes