Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances

Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgGI125 and RAM-nanodiamond-BSAI125 complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSAI125 complex is able to bind to the target antigen immobilized on the Sepharose 6B matrix through antibody–antigen interaction. The idea can be extended to use nanodiamonds as carriers for delivery of bioactive substances (i.e., drugs) to various targets in vivo

Reaction dynamics of the Sr(P-3(J))+RI->SrI+R (R = CH3, CH3CH2) systems: rotational alignment, electronic state branching ratio and vibrational state population of products

The Sr((3)p(J)) + RI --> SrI (A(2) Pi(1/2,3/2;) B-2 Sigma(+)) + R (R = CH3, CH3CH2) reactions have been studied by measuring their chemiluminescence under beam-gas conditions. The rotational alignment of the product Sri was obtained. In addition, the electronic state branching ratio and the product vibrational state population have been roughly estimated by simulating the chemiluminescent spectra of SrI. (C) 1997 Elsevier Science B.V