Vitamin E Prevents Lipogenesis Dysregulation in the Liver Cells at Old Age Vitamin E Prevents Lipogenesis Dysregulation in the Liver Cells at Old Age

Abstract Thyroid hormones play critical roles in lipogenesis regulation. Genomic dependent and genomic independent effects of triiodothyronine on free fatty acids (FFA) synthesis have been determined. The lipogenesis regulation with L-thyroxine (T4) in the liver cells of 3-and 24-month-old rats and effects of vitamin E (?-tocopherol acetate) or N-acetylcistein (NAC) on old liver response to hormone action have been investigated. T4 in both experiments in vivo and in vitro increased lipogenesis in liver cells of young rats, while old hepatocytes were resistant to the hormone action. Vitamin E as well as N-acetylcistein (NAC) increased significantly the liver and hepatocytes sensitivity to the T4 action at old age. However, the vitamin E-dependent induction of FFA synthesis with T4 was not followed by FFA accumulation. The newly synthesized FFA were used for cholesterol and neutral lipids synthesis in old liver cells treated with T4 plus vitamin E or NAC. The data obtained have demonstrated for the first time that the age-dependent lipogenesis dysregulation depends on redox state changes in liver. Vitamin E improved both the long-term and the short-term genomic independent thyroid hormone lipogenesis regulation at old age