3 research outputs found
Predictive diagnosis of endometrial hyperplasia and personalized therapeutic strategy in women of fertile age
Peculiarities of Fetoplacental Complex and Correction of Its Disturbances in the Women with Pulmonary Tuberculosis and Iron Deficiency Anemia
Π’ΡΠ±Π΅ΡΠΊΡΠ»ΡΠ· ΠΈ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΡ Π½Π° ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΡΡΠ°ΠΏΠ΅ ΡΠ²Π»ΡΡΡΡΡ Π½Π΅
ΡΠΎΠ»ΡΠΊΠΎ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ, Π½ΠΎ ΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ, Π² ΡΠ²ΡΠ·ΠΈ Ρ ΡΠΈΡΠΎΠΊΠΈΠΌ
ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠ΅ΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ Π²ΠΎ Π²ΡΠ΅Ρ
ΡΡΡΠ°Π½Π°Ρ
ΠΌΠΈΡΠ°, ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ
Ρ
ΠΈΠΌΠΈΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
ΡΠΎΡΠΌ ΡΡΠ±Π΅ΡΠΊΡΠ»ΡΠ·Π°, ΡΡ
ΡΠ΄ΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΆΠΈΠ·Π½ΠΈ ΠΈ
Π·Π΄ΠΎΡΠΎΠ²ΡΡ ΠΌΠ°ΡΠ΅ΡΠΈ ΠΈ ΡΠ΅Π±ΡΠ½ΠΊΠ°. ΠΡΠΎΠ±Π΅Π½Π½ΠΎ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π΅Ρ
Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΡ ΠΏΡΠΈ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ ΡΡΠ±Π΅ΡΠΊΡΠ»ΡΠ·Π° Π»ΡΠ³ΠΊΠΈΡ
ΠΈ Π΅Π³ΠΎ Π³Π΅ΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ β Π°Π½Π΅ΠΌΠΈΠΈ ΠΈ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠ»Π°ΡΠ΅Π½ΡΡ, ΠΊΠΎΡΠΎΡΡΠ΅ Π½Π°Π±Π»ΡΠ΄Π°ΡΡΡΡ Ρ 85 β
95 % ΠΆΠ΅Π½ΡΠΈΠ½. ΠΡΠΈ ΡΡΠΎΠΌ, Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΠΎΡΠ»ΠΎΠΆΠ½ΡΠ½Π½ΠΎΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ,
ΡΠΎΠ΄ΠΎΠ², Π΄ΠΈΡΡΡΠ΅ΡΡ-ΡΠΈΠ½Π΄ΡΠΎΠΌ ΠΈ Π³ΠΈΠΏΠΎΡΡΠΎΡΠΈΡ ΠΏΠ»ΠΎΠ΄Π°. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ, ΠΈΠ·ΡΡΠ΅Π½Ρ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ΅ΡΠΎΠΏΠ»Π°ΡΠ΅Π½ΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΡΠΊΠ°Π·Π°Π½Π½ΠΎΠΉ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ Π»Π΅ΡΠ΅Π±Π½ΠΎ-ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΡ Ρ
Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠΎΠ², Π°Π½ΡΠΈΠ³ΠΈΠΏΠΎΠΊΡΠ°Π½ΡΠΎΠ², ΠΆΠ΅Π»Π΅Π·ΠΎΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΈ ΠΎΠ·ΠΎΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ, ΠΎΠ±Π»Π°Π΄Π°ΡΡΠ΅ΠΉ Π±Π°ΠΊΡΠ΅ΡΠΈΡΠΈΠ΄Π½ΡΠΌ ΠΈ
Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΡΠΌΠΈ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΈ Π€ΠΠ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Ρ 97 ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΡΡΠ±Π΅ΡΠΊΡΠ»ΡΠ·ΠΎΠΌ Π»ΡΠ³ΠΊΠΈΡ
, ΠΎΡΠ»ΠΎΠΆΠ½ΡΠ½Π½ΡΠΌ ΠΠΠ. Π£ 91 % Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΡ ΠΏΠ»Π°ΡΠ΅Π½ΡΡ. ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠ½ΠΊΡΠΈΠΉ Π€ΠΠ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ
ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π³ΠΎΡΠΌΠΎΠ½ΠΎΠ² ΠΊΡΠΎΠ²ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ.
Π‘ΡΠ΅ΠΏΠ΅Π½Ρ Π³ΠΈΠΏΠΎΠΊΡΠΈΠΈ ΠΌΠ°ΡΠ΅ΡΠΈ ΠΈ ΠΏΠ»ΠΎΠ΄Π° ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΏΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌ ΠΊΠΈΡΠ»ΠΎΡΠ½ΠΎΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΊΡΠΎΠ²ΠΈ. Π’Π°ΠΊΠΆΠ΅ ΠΈΠ·ΡΡΠ°Π»ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΏΠ»ΠΎΠ΄Π° ΠΏΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ
ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΠΎΠΉ ΡΠ΅ΡΠΎΠΌΠ΅ΡΡΠΈΠΈ, ΠΏΠ»Π°ΡΠ΅Π½ΡΡΠΎΠ³ΡΠ°ΡΠΈΠΈ ΠΈ ΠΊΠ°ΡΠ΄ΠΈΠΎΡΠΎΠΊΠΎΠ³ΡΠ°ΡΠΈΠΈ ΠΏΠ»ΠΎΠ΄Π°. Π£
ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΡΡΠ±Π΅ΡΠΊΡΠ»ΡΠ·ΠΎΠΌ Π»ΡΠ³ΠΊΠΈΡ
ΠΈ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠ΅ΠΉ ΠΠΠ Π²ΡΡΠ²Π»Π΅Π½Ρ ΡΠ°Π·Ρ
Β«Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡΒ» ΠΈ Β«ΠΈΡΡΠΎΡΠ΅Π½ΠΈΡΒ» Π³ΠΎΡΠΌΠΎΠ½ΠΎΠ² Π€ΠΠ, Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ
Π°ΡΠΈΠ΄ΠΎΠ·Π° (ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ ΡΠ ΠΊΡΠΎΠ²ΠΈ, ΠΏΠ°ΡΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°,
ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠ³Π»Π΅ΠΊΠΈΡΠ»ΠΎΠ³ΠΎ Π³Π°Π·Π° ΠΈ Π±ΡΡΠ΅ΡΠ½ΡΡ
ΡΠΈΡΡΠ΅ΠΌ ΠΊΡΠΎΠ²ΠΈ).
ΠΠ°ΡΠ°Π»Π»Π΅Π»ΡΠ½ΠΎ ΠΊΠΎΠ½ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π±ΠΈΠΎΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ
ΠΏΡΠΎΡΠΈΠ»Ρ ΠΏΠ»ΠΎΠ΄Π°, Π½Π°Π»ΠΈΡΠΈΠ΅ Π΄ΠΈΡΡΡΠ΅ΡΡ-ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΠΈ Π³ΠΈΠΏΠΎΡΡΠΎΡΠΈΠΈ ΠΏΠ»ΠΎΠ΄Π°.
ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π»Π΅ΡΠ΅Π±Π½ΠΎ-ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ΅Π³ΠΎ
ΠΆΠ΅Π»Π΅Π·ΠΎΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ, Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΡ, Π°Π½ΡΠΈΠ³ΠΈΠΏΠΎΠΊΡΠ°Π½ΡΡ ΠΈ
ΠΎΠ·ΠΎΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΡΠ»ΡΡΡΠΈΡΡ ΠΎΠ±ΡΠ΅Π΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
, ΡΠ½ΠΈΠ·ΠΈΡΡ
ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π³Π΅ΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ, Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΠΎΠ²Π°ΡΡ ΡΡΠΎΠ²Π΅Π½Ρ Π³ΠΎΡΠΌΠΎΠ½ΠΎΠ²
Π€ΠΠ, ΡΠΌΠ΅Π½ΡΡΠΈΡΡ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°ΡΠΈΠ΄ΠΎΠ·Π°, ΡΠ»ΡΡΡΠΈΡΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅
ΠΏΠ»ΠΎΠ΄Π°.Now tuberculosis and pregnancy are both medical and social problem as
morbidity rate increases all over the world, chemo resistant forms occur and
quality of mother and child life worsening. Pregnancy has extremely unfavorable
course at coincidence of pulmonary tuberculosis and complications of gestation β
anemia and dysfunction of placenta which are observed in 85 β 95 % of women. In
this case complicated course of pregnancy, labours, distress-syndrome and
hypotrophy of a fetus take place. Objective: to investigate peculiarities of
fetoplacental complex (FPC) in women with the mentioned above pathology and
work out some therapeutical measures with inclusion of antioxidants,
antihypoxants, iron-containing drugs and therapy with ozone. Results.
Investigation of FPC was done in 97 women with pulmonary tuberculosis (PT) complicated with iron deficiency anemia (IDA). 91 % of pregnant had dysfunction
of placenta. FPC function was estimated by hormone concentration in blood (IFAmethod). Mother-fetus hypoxia was estimated by acidic-basic state of blood.
Ultrasonoric fetometria, placentography and cardiotocography was done, as well.
In the women with PT and attendant IDA phases of βtensionβ and βexhaustionβ of
FPC hormones, presence of metabolic acidosis (blood pH decrease, O2 partial
pressure, increase of CO2 concentration and buffer systems of blood). In parallel
the decrease of biophysical fetusβs profile, distress-syndrome presence and fetusβs
hypotrophy was observed. The use of the therapeutical complex with ironcontained drugs, anti-oxidants, antihypoxants, therapy with ozone allowed to
improve the general state of the pregnant, decrease the number of gestational
complications, normalize the level of FPC hormones, decrease symptoms of
metabolic acidosis and improve the state of fetus