Inspiratory fraction and exercise impairment in COPD patients GOLD stages II-III

The inspiratory-to-total lung capacity ratio or inspiratory fraction (inspiratory capacity (IC)/total lung capacity (TLC)) may be functionally more representative than traditional indices of resting airflow limitation and lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD).In the present retrospective study, a comparison was made of the individual performance of post-bronchodilator IC, IC/TLC and forced expiratory volume in one second (FEV1) in predicting a severely reduced peak oxygen uptake (V'o(2); < 60% predicted) in 44 COPD patients Global Initiative for Chronic Obstructive Lung Disease stages II-III (post-bronchodilator FEV1 ranging from 31-79% pred).Patients with lower IC/TLC values (<= 0.28) showed increased lung volumes and reduced exercise capacity as compared with other subjects. Following a multiple linear regression analysis, only IC/TLC and FEV1 remained as independent predictors of V'o(2) (r(2)=0.33). A receiver operating characteristic (ROC) curve analysis revealed that an IC/TLC <= 0.28 had the highest specificity (89.6%), positive predictive value (80%) and overall accuracy (86.3%) in identifying patients with V'o(2)< 60% pred. in addition, the area under the ROC curve tended to be higher for IC/TLC than IC.In conclusion, post-bronchodilator total lung capacity-corrected inspiratory fraction provides useful information in addition to forced expiratory volume in one second and inspiratory capacity, to estimate the likelihood of chronic obstructive pulmonary disease patients to present with severely reduced maximal exercise capacity.Universidade Federal de São Paulo, Paulista Sch Med, Pulm Funct & Clin Exercise Physiol Unit, Resp Div,Dept Med,EPM, BR-04020050 São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Med, Pulm Funct & Clin Exercise Physiol Unit, Resp Div,Dept Med,EPM, BR-04020050 São Paulo, BrazilWeb of Scienc

Effects of pollution on adolescent mental health: a systematic review protocol.

BACKGROUND: Whilst there is little uncertainty about the deleterious impact of pollution on human and planetary health, pollution's impact on adolescent mental health is less well understood. This is particularly true for young people in underdeveloped and developing world contexts, about whom research is generally lacking. Furthermore, although adolescent resilience continues to be a research priority, little attention has been paid to adolescent pathways of resilience in the face or aftermath of pollution exposure. The objective of this study will be to examine the associations between pollution and mental health in 10- to 24-year-olds (i.e. adolescents). METHODS: We designed and registered a study protocol for a systematic review of studies which link pollution and mental health in adolescents. We will include observational studies (e.g. cohort, case-control, time series analyses) that assess the associations between exposure to any form of pollution and the mental health of 10- to 24-year-olds. The primary outcome will be symptoms associated with neurodevelopmental disorders; disruptive, impulse-control, and conduct disorders; depressive disorders; anxiety disorders; substance disorders; and schizophrenia. No secondary outcomes will be considered. Literature searches will be conducted in multiple electronic databases (from inception onwards), including PubMed, MEDLINE, SCOPUS, Web of Science, CINAHL, PsycINFO, SciELO, ERIC, and Africa-Wide. Two investigators will independently screen all citations, full-text articles, and abstract data. The methodological quality (or bias) of included studies will be appraised using appropriate tools. We will provide a narrative synthesis of the evidence. DISCUSSION: This systematic review will evaluate the evidence on the associations between pollution and the mental health of 10- to 24-year-olds. Our findings will be of potential interest to multiple audiences (including adolescent patients/clients, their families, caregivers, healthcare professionals, scientists, and policy makers) and could be used to develop prevention and intervention strategies as well as focus future research. Results will be published in a peer-reviewed journal. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020176664

Expressão gênica da proteína de choque térmico (HSP70) no fígado de frangos de corte submetidos ou não a estresse térmico agudo.

Resumo: Avaliou-se a expressão do gene hsp70 no fígado de frangos de corte Cobb machos submetidos ou não ao estresse térmico no final das fases de crescimento (21 dias) e final (42 dias). O estudo consistiu de duas experiências: a primeira envolveu 60 frangos de corte mantidos a 27oC durante 20 dias, em seguida 30 frangos de corte foram submetidos a 38oC durante 24 horas; O segundo envolveu 60 frangos de corte mantidos a 27oC por 20 dias, depois transferidos para 19oC até completarem 41 dias de idade e em seguida 30 frangos de corte foram expostos a 38oC por 24 horas. Os frangos de corte tiveram a melhor eficiência homeotérmica aos 21 dias de idade, pois somente aos 42 dias o frango aumentou significativamente a expressão de hsp70. Os dados sugerem que frangos de corte mais jovens possuem mecanismos de tolerância, demonstrando a adaptação ao ambiente quando submetidos a estresse. Abstract: We evaluated the expression of the hsp70 gene in the liver of male Cobb broilers submitted or not to heat stress at the end of the starter (21 days) and finisher (42 days) growth phases. The study consisted of two experiments: the first involved 60 broilers kept at 27oC for 20 days and then 30 broilers were subjected to 38oC for 24 hours; the second involved 60 broilers maintained for kept at 27oC for 20 days 20 days, then transferred to 19oC until they completed 41 days of age, after which 30 broilers were exposed to 38oC for 24 hours. Broilers had the best homeothermic capacity efficiency at 21 days of age since only at 42 days the broiler significantly increased the expression of hsp70. The data suggest that young broiler breeders have tolerance mechanisms, demonstrating their adaptation to the environment when subjected to stress

A STUDY ABOUT CELL ACTIVITY ON ANODIZED Ti-6Al-4V BY MEANS OF PULSED CURRENT

Titanium and some of its alloys exhibit excellent anti-corrosive and biocompatibility properties due to rapid formation of a passive film on their surfaces when exposed to the atmosphere. However, such materials presentpoor osteoindutive properties. Surfaces modified via anodization are being proposed in this study to promote a chemical interaction between implants and bone cells. For this purpose, samples in Ti-6Al-4V alloy discs were anodized in a phosphoric acid solution using pulsed current for being applied in orthopaedic implants. The pulsed current is based on duty cycle (DC), which was supplied by a square wave pulse rectifier at 100 Hz and maximum tension of 30 V. A scanning electron microscope was used to obtain images of the anodized surfaces, thus revealing the presence of uniformly distributed pores over the entire surface, measuring approximately 2 m in diameter. Osteogenic cells grown on the surface of the control and anodized samples were assayed for cytotoxicity and mineralized matrix formation. The anodized surfaces presented a higher rate of viable cells after 10 days, as well as a higher amount of nodules (p = 0.05). In conclusion, these results suggest that the nanotopography promoted by anodization using pulsed current induces beneficial modulatory effects on osteoblastic cells