Theoretical Aspects of Creating the Business Models for Supply Chain Process of Industrial Enterprises

Abstract- Creating the business models for supply chain process is the subject of modern scientific research in the field of strategic planning and management of the enterprise. Some theoretical and practical aspects have not yet received a comprehensive scientific substantiation. General problem of enterprise management is traditionally analyzed in the researches, and business modeling is not fully investigated. The current state of the economy and peculiarities of its development, as well as the transformational nature of the Russian economy, show that the most important theoretical and practical aspects, which require scientific attention and development, analysis and systematization, are the theoretical provisions of business modeling concept for supply chain process; clarification of the term "business model" for supply chain process of an industrial enterprise; definition of the main elements and substantiation of the technology of business model formation; systematization and generalization of modern methods of strategic analysis; formation of an integrated system for assessment the effectiveness of the enterprises business model for supply chain process. The issues of strategic development of the enterprise always arouse a great interest among researchers. Today, a significant number of business models have been created for the development of enterprises of various industry structures. The purpose of the article is to systematize the information about the creation of business models for supply chain process of industrial enterprises, to consider the features of the models use at the present stage. Scientific and theoretical basis of the research was the methods of analysis and synthesis, scientific abstraction, the use of quantitative and qualitative assessment methods, with the help of which the categories of the concept business model for the supply chain process were defined. Endogenous and exogenous factors, influencing the functioning of enterprises business models were identified. The article deals with the conceptual issues of the business model for the supply chain process formation, in particular, the essence and peculiarities of modern business models, as well as management approaches to the processes of development of enterprises business model for supply chain process. Keywords: business model, strategic development, industrial enterprise, supply chain process, creation

Spiral-Wave Turbulence and Its Control in the Presence of Inhomogeneities in Four Mathematical Models of Cardiac Tissue

Regular electrical activation waves in cardiac tissue lead to the rhythmic contraction and expansion of the heart that ensures blood supply to the whole body. Irregularities in the propagation of these activation waves can result in cardiac arrhythmias, like ventricular tachycardia (VT) and ventricular fibrillation (VF), which are major causes of death in the industrialised world. Indeed there is growing consensus that spiral or scroll waves of electrical activation in cardiac tissue are associated with VT, whereas, when these waves break to yield spiral- or scroll-wave turbulence, VT develops into life-threatening VF: in the absence of medical intervention, this makes the heart incapable of pumping blood and a patient dies in roughly two-and-a-half minutes after the initiation of VF. Thus studies of spiral- and scroll-wave dynamics in cardiac tissue pose important challenges for in vivo and in vitro experimental studies and for in silico numerical studies of mathematical models for cardiac tissue. A major goal here is to develop low-amplitude defibrillation schemes for the elimination of VT and VF, especially in the presence of inhomogeneities that occur commonly in cardiac tissue. We present a detailed and systematic study of spiral- and scroll-wave turbulence and spatiotemporal chaos in four mathematical models for cardiac tissue, namely, the Panfilov, Luo-Rudy phase 1 (LRI), reduced Priebe-Beuckelmann (RPB) models, and the model of ten Tusscher, Noble, Noble, and Panfilov (TNNP). In particular, we use extensive numerical simulations to elucidate the interaction of spiral and scroll waves in these models with conduction and ionic inhomogeneities; we also examine the suppression of spiral- and scroll-wave turbulence by low-amplitude control pulses. Our central qualitative result is that, in all these models, the dynamics of such spiral waves depends very sensitively on such inhomogeneities. We also study two types of control schemes that have been suggested for the control of spiral turbulence, via low amplitude current pulses, in such mathematical models for cardiac tissue; our investigations here are designed to examine the efficacy of such control schemes in the presence of inhomogeneities. We find that a local pulsing scheme does not suppress spiral turbulence in the presence of inhomogeneities; but a scheme that uses control pulses on a spatially extended mesh is more successful in the elimination of spiral turbulence. We discuss the theoretical and experimental implications of our study that have a direct bearing on defibrillation, the control of life-threatening cardiac arrhythmias such as ventricular fibrillation

Inhibition of the Nicotinic Acetylcholine Receptors by Cobra Venom α-Neurotoxins: Is There a Perspective in Lung Cancer Treatment?

Nicotine exerts its oncogenic effects through the binding to nicotinic acetylcholine receptors (nAChRs) and the activation of downstream pathways that block apoptosis and promote neo-angiogenesis. The nAChRs of the α7 subtype are present on a wide variety of cancer cells and their inhibition by cobra venom neurotoxins has been proposed in several articles and reviews as a potential innovative lung cancer therapy. However, since part of the published results was recently retracted, we believe that the antitumoral activity of cobra venom neurotoxins needs to be independently re-evaluated