Vision-related symptoms as a clinical feature of chronic fatigue syndrome/myalgic encephalomyelitis? Evidence from the DePaul Symptom Questionnaire

Chronic Fatigue Syndrome (CFS) or Myalgic Encephalomyelitis (ME) is a debilitating disorder, affecting at least 250,000 people in the UK. Marked by debilitating fatigue, its aetiology is poorly understood and diagnosis controversial. A number of symptoms overlap with other illnesses with the result that CFS/ME is commonly misdiagnosed. It is important therefore that significant clinical features are investigated. People diagnosed with CFS/ME consistently report that they experience vision-related symptoms associated with their illness1-3 with some of these reports being verified experimentally. Although vision-related symptoms may represent a significant clinical feature of CFS/ME that could be useful in its diagnosis, they have yet to be included in clinical guidelines

Development of high strength, high thermal conductivity cold sprayed coatings to improve thermal management in hybrid motorcycles

The deposition of thick, pore-free, high-performance copper alloy matrix composite coatings is a topic of interest for several industrial applications, including friction materials, high-strength electrical contacts, and welding electrodes, among others. This study investigates the use of cold spray to deposit CuCrZr/Al2O3 cermet coatings on aluminum alloy 6060. The objective is to integrate copper-based materials with aluminum-based materials, ensuring a high degree of mechanical and thermal contact, using a low temperature process that does not adversely affect the properties of the base materials. This technique can be used to produce integral coolers and aluminum-based bearings for automotive and motorcycle applications. Fused and crushed alumina and gas-atomized CuCrZr powder blends have been used as initial feedstocks, with compositional weight ratios of 65/35 and 80/20 (ceramic/metal). The coatings have been characterized in terms of microstructure and morphology, coating microindentation hardness, cohesion strength, and adhesion strength to the aluminum alloy substrate. Microindentation hardness greater than 200 Vickers, adhesion strength greater than 50 MPa, and cohesion strength up to 250 MPa have been obtained. Thermal conductivity up to 110 W/mK has been obtained for both as-deposited and thermally-annealed coatings

Arhgap10, A Novel Human Gene Coding For A Potentially Cytoskeletal Rho-gtpase Activating Protein.

Rho-GTPase activating proteins (Rho-GAPs) are negative regulators of Rho-GTPase signaling pathways related to actin cytoskeleton dynamics, cell proliferation, and differentiation. We have identified a novel human gene, termed ARHGAP10, that codes for a 1957-aminoacid Rho-GAP, containing a PDZ, a PH, and a Rho-GAP domain. The cDNA is 7118 bp long and has an open reading frame of 5874 bp. A computational analysis located this gene on chromosome 10 band 10p12.32 suggesting that it is composed of 25 exons. Northern analysis revealed that it is widely expressed, with high levels in brain and muscle. Real-time quantitative PCR analysis confirmed an increase in ARHGAP10 expression during differentiation of HL-60 cells with all-trans-retinoic acid and hematopoietic stem cells with erythropoietin, suggesting that this gene could play a role in normal hematopoiesis. The fact that this gene is highly expressed in muscle and brain, which are highly differentiated tissues, further supports the hypothesis that ARHGAP10 is important for cell differentiation.294579-8

Predictors of aging out of heavy episodic drinking in emerging adults: A systematic review protocol

Background: Heavy episodic drinking (HED) refers to alcohol consumption that exceeds the recommended threshold for a given episode and increases risk for diverse negative alcohol-related consequences. A pattern of weekly HED is most prevalent in emerging adults (i.e., age 18-25). However, rates of HED consistently decline in the mid to late twenties, referred to as \u27aging out\u27 or \u27maturing out\u27 of HED. Although many individual studies have followed changes in drinking behaviour over the transition to adulthood, there has yet to be a systematic review to identify consistent factors contributing to risk (i.e. failure to age out) and protection (i.e. successful aging out). The objective of this review will be to summarize and critically appraise the literature on factors contributing to aging out of HED among emerging adults. Methods: A systematic search of observational cohort studies following drinking behaviours in age cohorts overlapping with the emerging adulthood period will be conducted in MEDLINE, EMBASE, PsychInfo, and CINAHL. Two independent reviewers will evaluate identified studies for inclusion eligibility, extract study data, and assess the quality of included studies. Primary outcomes will be quantity/frequency of alcohol use (e.g. drinks/week) and severity of alcohol-related problems. Predictors of maturing out of HED will be reported narratively, and where appropriate, random effects meta-analyses will be conducted to provide pooled effect sizes. An evidence map will be created to characterize the overall pattern of findings. Discussion: This systematic review will provide a timely and warranted summary of published work contributing to understanding aging out of heavy episodic drinking. Our findings will provide critical commentary on the developmental course of HED during the transition from adolescence to adulthood and will be the first review to consider both protective and risk factors for maturing out of frequent binge drinking. By highlighting factors identifying those at-risk for prolonged heavy episodic drinking, our conclusions will have important treatment implications for primary, secondary, and tertiary intervention strategies. Systematic review registration: PROSPERO CRD42017078436

"Well-Staged Syllables". From Classical to Early Modern English Metres in Drama

This special issue is devoted to a discussion of classical and early modern versification in drama. It also contains articles on linguistic and performative analysis applied to drama and dance, on early modern and modern drama, as well as on 2021 festivals of ancient drama, contemporary theatre and Shakespeare