Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration

Kinesin-5 is traditionally considered a mitotic motor protein. This article presents evidence that kinesin-5 is also critically influential in the process of neuronal migration, wherein terminally postmitotic neurons undergo orderly movement from their sites of birth to their final destinations

Kinesin molecular motor Eg5 functions during polypeptide synthesis

The microtubule motor Eg5 is well known for its functions during mitosis. It is shown that during interphase, Eg5 associates with ribosomes and is required for efficient protein synthesis

Kinesins and cancer

Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few years kinesins that are involved in mitosis have emerged as potential targets for cancer drug development. Several compounds that inhibit two mitotic kinesins (EG5 (also known as KIF11) and centromere-associated protein E (CENPE)) have entered Phase I and II clinical trials either as monotherapies or in combination with other drugs. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the range of kinesin-based drug targets may expand in the future

A guide to the Treaty of Amsterdam

SIGLEAvailable from British Library Document Supply Centre-DSC:4567.4766(1/98) / BLDSC - British Library Document Supply CentreGBUnited Kingdo