Primary Cardiac Allograft Dysfunction-Validation of a Clinical Definition

Background.Heart transplantation is an established treatment for advanced heart failure. Primary allograft dysfunction (PGD) is reported in up to 40 % of transplants and is associated with a poor outcome.Methods.As part of Heart Evaluation and Retrieval for Transplantation study, an investigation of the assessment of donor hearts for transplantation, we proposed a clinical definition ffecting one or both ventricles accompanied by hypotension, low 72 hours (in the absence of hyper acute rejection and technical mine the prospective application of this definition to 290 heart d non-PGD cases. Results. Ninety-four of 290 transplants the PGD group at 24, 48, and 72 hours after transplantation fo ra o c ty. have acceptable function before organ retrieval may be ex-OriginalClinicalScienceçGeneral30 years.6 This has been attributed to improvements in dono