SENSOR APPLICATIONS IN ANALYSIS OF DRUGS AND FORMULATIONS

Several sensors, biosensors, and actuators are designed and mounted to analyze biomedical nutraceuticals, food, and nutraceutical products in this particular issue. Some applications concern classical subjects such as eubacteria determination in agricultural products, flashing material in foods such as the ethyl group’s chemicals, and fruit juices’ inhibitor properties. In contrast, the different applications are more revolutionary, such as safety research, the manufacture of artificial human senses (electronic nose or tongue), or t Ligands are often characterized by nano biosensors, utilizing biomaterials that involve specific aptamers, antibodies, enzymes, polymers, and sensory receptors. The square measurement of several modal sensing elements, integrated with nanomaterials, increases sensitivity such as nano biosensors and increases nano biosensor productivity. For the nano biosensor with increased efficiency, modality sensing components have been incorporated in this case. The square measurement of the elastic (ME) magnetic machine biosensors was used to classify infectious agents by a magnet coil in contemporary juice or milk and to develop direct detection of infectious agents on food scanning coils

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF SITAGLIPTIN AND METFORMIN IN BULK AND COMBINED PHARMACEUTICAL FORMULATION

Objective: To develop simple, accurate, precise UV Spectrophotometric method for the simultaneous estimation of Sitagliptin and Metformin in tablet dosage form. Methodols: The method is based on the determination of Sitagliptin and Metformin in tablet using simultaneous equation method. Sitagliptin exhibits maximum absorbance at 267 and Metformin exhibits maximum absorbance at 237 nm using distilled water as diluents. Results: The calibration curve was linear in the range of 10-300 µg/ml for Sitagliptin and 4-14µg/ml for Metformin. The %RSD were within the limit i.e., less than 2%. The % recovery of the proposed method was found to be 97.12-99.46% for Sitagliptin and 98.15-99.85% for Metformin. The LOD of the proposed method was 0.397μg/ml for Sitagliptin and 0.8952µg/ml for Metformin. The LOQ was 1.2951μg/ml for Sitagliptin and 2.7159μg/ml for Metformin. Conclusion: A simple, accurate, precise UV Spectrophotometric method for the simultaneous estimation of Sitagliptin and Metformin in tablet dosage form