Diuretics in the treatment of patients with arterial hypertension: results of the DOVERIE comparative study

The use of thiazide, thiazide-like and loop diuretics in patients with hypertension is widely discussed. So far, there have been few direct comparative studies of different classes of diuretics in hypertension. The randomized, comparative, open DOVERIE study (efficacy and safety of Diuver in combination therapy in hypertensive patients in outpatient setting) found that the antihypertensive effects and safety of torasemide and indapamide are not significantly different. Adding torasemide either to monotherapy with ACEI/ARB II or as substitute for hydrochlorothiazide in combination therapy with ACEI/ARB II + HCTZ resulted in a further significant decrease in blood pressure and allowed to reach target BP in a majority of patients. Therapy with torasemide was not associated with any increase in heart rate, significant changes in potassium levels, uric acid and glucose