Insulator function and topological domain border strength scale with architectural protein occupancy

10.1186/gb-2014-15-5-r82Genome biology156R8

as a therapeutic agent against pancreatic cancer

10.1158/1535-7163.MCT-14-0485Molecular Cancer Therapeutics142407-41

Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing

10.1016/j.molcel.2015.02.023Molecular Cell582216-23

Author Correction: Widespread long-range cis-regulatory elements in the maize genome.

An amendment to this paper has been published and can be accessed via a link at the top of the paper

Widespread long-range cis-regulatory elements in the maize genome.

Genetic mapping studies on crops suggest that agronomic traits can be controlled by gene–distal intergenic loci. Despite the biological importance and the potential agronomic utility of these loci, they remain virtually uncharacterized in all crop species to date. Here, we provide genetic, epigenomic and functional molecular evidence to support the widespread existence of gene–distal (hereafter, distal) loci that act as long-range transcriptional cis-regulatory elements (CREs) in the maize genome. Such loci are enriched for euchromatic features that suggest their regulatory functions. Chromatin loops link together putative CREs with genes and recapitulate genetic interactions. Putative CREs also display elevated transcriptional enhancer activities, as measured by self-transcribing active regulatory region sequencing. These results provide functional support for the widespread existence of CREs that act over large genomic distances to control gene expression