The methodology of the analysis and synthesis of rational choice recipes of cooking dishes

In the analysis and synthesis, an assessment is conducted according to the criteria of rational choice of the layout solution from the arrays of the formed set of recipes for the preparation of recommended dishes. From the array of new, well-known recipes and their technologies of preparation of various dishes by analysis and synthesis of layout solutions the methodology of rational choice of dishes, allowing for different criteria to establish the best possible choice is propose

Impact of baking properties of wheat flour on change the parameters of kneading and rheological characteristics of the dough

The most important task facing the baking industry is to ensure the production of high quality products and of diverse range. Carrying out kneading has a great influence on the course of the technological process of preparation of wheat bread and its quality. Kneading the dough is the most important initial stage of the production of wheat bread, which occurs, first, the formation of the dough as a single homogeneous system, and, secondly, giving this system certain rheological properties, ensuring the optimal flow of all technological processe

Comparative analysis of the concentrations of proinflammatory cytokines and glycosylated ferritin in patients with idiopathic recurrent pericarditis and adult-onset Still's disease

Idiopathic recurrent pericarditis (IRP) and adult-onset Still's disease (AOSD) are polygenic autoinflammatory diseases, in the pathogenesis of which pro-inflammatory cytokines from the interleukin-1 superfamily play a central role.Aim. To compare serum concentrations of proinflammatory cytokines and glycosylated ferritin (GF) in patients with IRP and AOSD during an exacerbation.Material and methods. The study included 15 patients with AOSD, 15 — IRP. The diagnosis of AOSD was established using the Yamaguchi criteria (1992). IRP was diagnosed in accordance with the 2015 European Society of Cardiology on the diagnosis and management of pericardial diseases. Blood sampling from all patients was carried out during the recurrence period prior to the anti-inflammatory therapy initiation. The serum levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-18 (IL-18), procalcitonin, total ferritin and GF was assessed. The results obtained were compared with levels of biochemical parameters, high-sensitivity C-reactive protein (CRP), as well as with white blood cell (WBC) and neutrophil counts.Results. The median age in the AOSD group was 28 years, and the IRP — 55 years. An increase WBC count >10*109/L was detected in 10 and 9 patients in the AOSD and IRP groups, respectively. The concentration of CRP was increased in all patients and did not differ in the study groups (p=0,836).The highest values of ferritin and GF levels were found in the AOSD group (1416 ng/ml vs 408 ng/ml, p=0,008) and (12% vs 33,9%, p=0,067), respectively. In both groups, increased concentrations of IL-6 and IL-18 were determined. In the AOSD group, the concentration of IL-18 was higher than in the IRP group (2114 pg/ml vs 161,5 pg/ml, p<0,001). IL-6 concentrations in the study groups did not differ (33,9 pg/ml vs 24,9 pg/ml, p=0,4). IL-1β serum concentration in all subjects corresponded to normal values.Correlation analysis in the AOSD group revealed a direct relationship between the IL-18 and ferritin concentrations (rs=0,73, p=0,03).Conclusion. The study established a similar pattern of changes in inflammatory biomarkers in patients with AOSD and IRI. The most informative marker of inflammation was IL-18

Difficulties in diagnosis and treatment of adult-onset Still's disease concurrent with pericardial effusion as a leading clinical manifestation

The paper considers a case of adult-onset Still's disease that occurred as acute pericarditis, two-spike hectic fever, and neutrophilic leukocytosis in a young man. It was difficult to establish a correct diagnosis because there were no characteristic clinical symptoms of Still's disease, such as salmon colored rash, arthralgia, and sore throat. The diagnosis of adult-onset Still's disease was verified on the basis of the classification criteria described by M. Yamaguchi et al. The special feature of the clinical case was the development of steroid resistance and the effective use of a combination of the interleukin-6 receptor blocker tocilizumab (8 mg/kg body weight, given intravenously dropwise once every four weeks) and methotrexate (15 mg/week orally). During this treatment, a sustained clinical and laboratory response was achieved, which could reduce the dose of glucocorticoids to the maintaining one

Трудности диагностики и лечения болезни Стилла взрослых, протекавшей с экссудативным перикардитом в качестве ведущего клинического проявления

The paper considers a case of adult-onset Still's disease that occurred as acute pericarditis, two-spike hectic fever, and neutrophilic leukocytosis in a young man. It was difficult to establish a correct diagnosis because there were no characteristic clinical symptoms of Still's disease, such as salmon colored rash, arthralgia, and sore throat. The diagnosis of adult-onset Still's disease was verified on the basis of the classification criteria described by M. Yamaguchi et al. The special feature of the clinical case was the development of steroid resistance and the effective use of a combination of the interleukin-6 receptor blocker tocilizumab (8 mg/kg body weight, given intravenously dropwise once every four weeks) and methotrexate (15 mg/week orally). During this treatment, a sustained clinical and laboratory response was achieved, which could reduce the dose of glucocorticoids to the maintaining one.В статье рассматривается случай болезни Стилла у молодого мужчины, дебютировавшей симптомами острого перикардита, гектической двупиковой лихорадки и нейтрофильного лейкоцитоза. Установить правильный диагноз было сложно из-за отсутствия характерных клинических симптомов болезни Стилла, таких как сыпь («salmon-coloured» rash), артрит, боль в горле. Верификация диагноза болезни Стилла взрослых была выполнена на основании критериев M. Yamaguchi и соавт. Особенностями клинического случая явились развитие стероидорезистентности и эффективное применение комбинации блокатора рецептора интерлейкина 6 тоцилизумаба (8 мг/кг массы тела внутривенно капельно 1 раз в 4 нед) с метотрексатом (15 мг/нед внутрь). На фоне лечения был достигнут стойкий клинико-лабораторный ответ, позволивший снизить дозу глюкокортикоидов до поддерживающей

Idiopathic recurrent pericarditis — a paradigm shift?

Idiopathic recurrent  pericarditis (IRP) is a relatively rare inflammatory disease of the pericardium,  often  requiring  emergency medical  care,   associated with a  high percentage of temporary  disability and  significant  economic  costs.  The review presents various  points  of view on  the  pathogenesis of recurrent   pericarditis, discusses the role of autoinflammation.  It touches on treatment issues  based  on modern  data  on the IRP immunopathogenesis, and considers promising areas  of laboratory diagnostics