The influence of individual genetic polymorphisms on postmenopausal osteoporosis treatment effectiveness

Objective: study of associations between VDR gene rs1544410 and rs10735810 polymorphisms, MCM6 gene rs4988235, CALCR gene rs1801197 one and ibandronate efficacy in women with postmenopausal osteoporosis.Materials and methods: 117 women with postmenopausal osteoporosis were examined for 12 months in the dynamics of treatment with ibandronate. Evaluation of therapy effectiveness was based on indicators of increase in bone mineral density in L1-L4 lumbar vertebrae, as well as left and right femurs.Results: An association of GG genotype of VDR gene rs1544410 polymorphism with low growth rates of mineral density of L1-L4 lumbar vertebrae (3,41 ± 0,60 % versus 5,51 ± 0,78 % in other women; р = 0,036) was established. The effect of other studied polymorphisms (rs10735810 of VDR gene, rs4988235 of MCM6 gene, rs1801197 of CALCR gene) on treatment effectiveness was not found.Conclusion: it is advisable to use obtained results when developing personalized regimens for antiresorptive therapy for women with postmenopausal osteoporosis

Ichthyosis as one of the forms of hereditary pathology of fetus and newborn

A retrospective analysis of the course of pregnancy and childbirth during the birth of a child with a congenital pathology «ichthyosis» was carried out. This clinical case is interesting because fetal ichthyosis was not diagnosed during pregnancy, but all the signs of this disease were revealed in the newborn after the birth

METABOLISM OF GLIOFIBRILLARY ACIDIC PROTEIN IN PREGNANT WOMEN WITH POST-CONCUSSION SYNDROME

The aim: to evaluate the astroglial neurospecific protein – gliofibrillary acidic protein (GFAP) in the blood serum of pregnant women with post-concussion syndrome (PCS) resulted from a mild closed brain injury. The serum level of GFAP was earlier proposed to be used as a marker of the state of the blood-brain barrier (BBB) and a predictor of obstetric and perinatal complications.Materials and methods. To evaluate the permeability of the BBB and the integrity of astrocytes during pregnancy, we measured GFAP (using the enzyme immunoassay) in the sera of 93 women: 41 with PCS (main group), 31 somatically healthy pregnant women (comparison group), and 21 non-pregnant women of the reproductive age (control group).Results. In healthy pregnant women, the level of GFAP did not significantly differ from that in the non-pregnant women and did not exceed a threshold value of 4.0 ng/ml. In most of the pregnant women with PCS (70.73%), the GFAP values exceeded the threshold level starting from the first trimester and tended to increase subsequently, which was indicative of immunological sensitization.Conclusion. In the obstetric and neurological practice, pregnant women with PCS are recommend to be tested for their serum GFAP as a marker of immunological sensitization and a predictor of pregnancy and delivery complications as well as neurological deterioration

Cerebral hemodynamics in pregnant women with post-concussion syndrome

Cerebral hemodynamics in pregnant women with post-concussion syndrome Simrok V. V., Tsyganenko I. V. Lugansk State Medical University named after St. Luke There is a functional insufficiency and exhaustion of the involved vascular control mechanisms on the background of a post-concussion syndrome (PCS) during pregnancy. The aim of the study was to research the dynamics of blood circulation in the cerebral vessels of pregnant women with PCS by the method of transcranial triplex scanning using Power Doppler Imaging and ultrasonic Doppler examination. Patients and Methods: 37 pregnant women with PCS (group of pregnant women after an open craniocerebral trauma (OCT)) and 26 healthy pregnant women (group HP) were examined. Results: of the study and their discussion. Comparative analysis of changes in the level of blood flow in the brain arteries in the OCT and HP groups revealed a significant difference between the values in both groups (increasing peak systolic blood flow velocity (Vps) and decreasing end-diastolic blood flow velocity (Ved) in the OCT group in comparison with the HP group). From 12 to 24 weeks of pregnancy a cerebral blood flow in pregnant women in the OCT group was characterized by an increased IR by a factor of 1.17 (p Conclusions: the ultrasonic Doppler examination revealed the violations of autoregulation of cerebral blood flow in pregnant women with PCS. The violations have a hyperconstrictive character and worsen from 12 to 24 weeks of pregnancy, which requires the appointment of therapeutic and preventive therapy to prevent the development of complications of pregnancy and improve the overall condition of pregnant women with PCS. Key words: pregnant women, post-concussion syndrome, transcranial triplex scanning, ultrasonic Doppler examination, cerebral blood flow. For citation: Simrok V.V., Tsyganenko I.V. Cerebral hemodynamics in pregnant women with post-concussion syndrome //&nbsp; RMJ. 2018. № 2(I). P. 26–28.<br