FEATURES OF CLINICAL DISPLAYS OF THE TRANSPLANTED HEART ACUTE REJECTION

In the present research features of current of clinical and structural changes are considered at acute rejection at the patients who have carried orthotopic transplantation of heart. Results of retrospective research are based on studying 1119 endomyocardial biopsy in a combination to clinical displays, given invasive and the noninvasive techniques of diagnostics used at 62 recipients of heart recipients before 10-years period of supervision. Character of changes of wall thicknes of LV, mass of a myocardium, ventricular end diastolic volume, and also a degree of infringement of pump function allow to characterize distinctions in clinical displays acute cellular and humoral rejection

METABOLIC AND AUTOIMMUNE RISK FACTORS FOR CORONARY ARTERY DISEASE (CAD) IN HEART TRANSPLANT RECIPIENTS

One of the most essential autoimmunity risk factors for development of CAD are increasing level of anticardiolipin antibodies and homocystein. This report presents retrospective analyses of 39 heart transplant recipients with maximal follow up over 16 years. Our results showed that hyperhomocystenemia and high levels of anticardiolipin antibodies play great value in development of CAD. Thus relative risks for development of CAD in presence both high levels of anticardiolipin antibodies and homocysteine are higher, than in traditional nonimmune risk factors

К ВОПРОСУ О БЕЗОПАСНОСТИ ИСПОЛЬЗОВАНИЯ РЕНТГЕНОКОНТРАСТНЫХ ВЕЩЕСТВ ПРИ ПРОВЕДЕНИИ КОРОНАРНОЙ АНГИОПЛАСТИКИ У РЕЦИПИЕНТОВ ПОЧЕЧНОГО ТРАНСПЛАНТАТА

In the present study influence of contrast media on renal transplant function in patients with ischemic heart disease treated by coronary angioplasty and stenting waz estimated. Results are based on clinical and angiographic data, the analysis of amount of contrast media, average speed of it introduction, level of creatinine before and at the first 48 hours after coronary angioplasty in 42 patients with renal transplant. В настоящем исследовании анализируется влияние контрастного вещества на функцию почечного трансплантата у пациентов с ишемической болезнью сердца, которым проводилась коронарная ангиопластика со стентированием. Результаты исследования базируются на клинических и ангиографических данных, анализе количества контрастного вещества, средней скорости введения контрастного вещества, уровня креатинина до и в первые 48 часов после коронарной ангиопластики у 42 реципиентов почечного транс- плантата.

ON THE SAFETY OF CONTRAST MEDIA USAGE DURING CORONARY ANGIOPLASTY IN KIDNEY TRANSPLANT RECIPIENTS

In the present study influence of contrast media on renal transplant function in patients with ischemic heart disease treated by coronary angioplasty and stenting waz estimated. Results are based on clinical and angiographic data, the analysis of amount of contrast media, average speed of it introduction, level of creatinine before and at the first 48 hours after coronary angioplasty in 42 patients with renal transplant

THE FIRST EXPERIENCE OF CLINICAL APPLICATION AUTOLOGICAL MEZENCHIMAL BONE MARROW STEM CELLS FOR REHABILITATION OF RETRACTIVE MYOCARDIAL FUNCTION

The previouse experimental studies revealed that mezenchimal bone marrow stem cells (MSC) have the ability of differentiating into cardiomiocytes in vitro and in vivo inducting angiogenesis and restoring the impared myocardial function. At that, the cell technology capacities in clinical cardiology remain unstudied.Starting from January 2003 8 patients suffering from heart failure underwent the transplantation of autological MSC with different stages of cultivation: MSC was administered intracoronary to 6 and intramuraly to the post-infarction cardiosclerosis zone. In three cases the MSC were marked with thallium-20 Idirectly before transplantation in order to define the location of MSC during the hours after transplantation. The results of radionuclide scintigraphy demonstrated that in 1, 5 hours after intracoronary administration and in 6, 5 hours after intramyocardial injection MSC remain in the zone of administration. In 1 month after the transplantation the improvement of regional perfusion and diastolic function was observed in old patients. Significant growth of functional ischemia of the left ventricle from 31 to 40 % was observed in patient suffering from ИКМП after intramural administration of MSC. In 1 month after MSC transplantation quality of life and phisical stress tolerance improvement was observed. Intracoronary administered MSC remain in coronary artery, through which MSC was administered. Intracoronary and intramural administration of MSC improves functional indices of retractive myocardial function, increases physical stress tolerance and life quality of patients suffering from chronic heart failure