38 research outputs found
Trafficking activity of myosin XXI is required in assembly of Leishmania flagellum
Actin-based myosin motors have a pivotal role in intracellular trafficking in eukaryotic cells. The parasitic protozoan organism Leishmania expresses a novel class of myosin, myosin XXI (Myo21), which is preferentially localized at the proximal region of the flagellum. However, its function in this organism remains largely unknown. Here, we show that Myo21 interacts with actin, and its expression is dependent of the growth stage. We further reveal that depletion of Myo21 levels results in impairment of the flagellar assembly and intracellular trafficking. These defects are, however, reversed by episomal complementation. Additionally, it is shown that deletion of the Myo21 gene leads to generation of ploidy, suggesting an essential role of Myo21 in survival of Leishmania cells. Together, these results indicate that actin-dependent trafficking activity of Myo21 is essentially required during assembly of the Leishmania flagellum
Heliothis species and their natural enemies, with their potential for biological control
Breeding Records of the Asian Brown Flycatcher Muscicapa Dauurica in Southern India
Volume: 100Start Page: 146End Page: 14
Fruit and Nectar Resources in a Moist Deciduous Forest and Their Use by Birds: a Preliminary Report
Volume: 99Start Page: 537End Page: 54
Duetting Calls of the Heart spotted Woodpeckers Hemicircus Canente (Lesson)
Volume: 101Start Page: 157End Page: 15
Five striped Palm Squirrel (Funnambulus Pennantii) in Rishi Valley, Chittoor District, Andhra Pradesh
Volume: 104Start Page: 202End Page: 20
ON THE OCCURRENCE AND STATUS OF RINGED PLOVER CHARADRIUS-HIATICULA LOWE IN MADRAS CITY SOUTHERN INDIA
Volume: 86Start Page: 101End Page: 10