To punish first and reward second: Values determine how reward and punishment affect risk-taking behavior

The current study investigated whether manipulating participants’ pre-exposure to reward and punishment affects the extent to which sensation seeking and values predict risk-taking behavior. Participants (n = 195) were randomly allocated to one of two conditions, defined by the order at which they were rewarded or punished for risk-taking behavior. Risk-taking behavior was measured in both conditions using the Balloon Analogue Risk Test, however this was set-up such that participants in group 1 were rewarded for risk-taking behavior prior to being punished, whereas participants in group 2 were punished for risk-taking behavior prior to being rewarded. Participants also completed questionnaires designed to measure sensation seeking and the values of ‘stimulation’ (the need for novelty and excitement) and ‘hedonism’ (the need for sensuous pleasure). It was found that stimulation predicted risk taking behavior in the ‘reward-then-punishment’ condition, whereas hedonism predicted risk-taking behavior in the ‘punishment-then-reward’ condition. Sensation-seeking was found to be an indirect predictor of risk-taking behavior in both conditions. It is tentatively concluded that the extent to which an individual’s risk-taking behavior is guided by their values (hedonism, stimulation) largely depends on their prior exposure to the order of contingent reward and punishment

Folding of Cu, Zn superoxide dismutase and Familial Amyotrophic Lateral Sclerosis

Cu,Zn superoxide dismutase (SOD1) has been implicated in the familial form of the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS). It has been suggested that mutant mediated SOD1 misfolding/aggregation is an integral part of the pathology of ALS. We study the folding thermodynamics and kinetics of SOD1 using a hybrid molecular dynamics approach. We reproduce the experimentally observed SOD1 folding thermodynamics and find that the residues which contribute the most to SOD1 thermal stability are also crucial for apparent two-state folding kinetics. Surprisingly, we find that these residues are located on the surface of the protein and not in the hydrophobic core. Mutations in some of the identified residues are found in patients with the disease. We argue that the identified residues may play an important role in aggregation. To further characterize the folding of SOD1, we study the role of cysteine residues in folding and find that non-native disulfide bond formation may significantly alter SOD1 folding dynamics and aggregation propensity.Comment: 16 pages, 5 figure

On the Zariski-Lipman conjecture for normal algebraic surfaces

We consider the Zariski-Lipman Conjecture on free module of derivations for algebraic surfaces. Using the theory of non-complete algebraic surfaces, and some basic results about ruled surfaces, we will prove the conjecture for several classes of affine and projective surfaces.Comment: Final version; to appear in Jour. London Math. So

On the MHD load and the MHD metage

In analogy with the load and the metage in hydrodynamics, we define magnetohydrodynamic load and magnetohydrodynamic metage in the case of magnetofluids. They can be used to write the magnetic field in MHD in Clebsch's form. We show how these two concepts can be utilised to derive the magnetic analogue of the Ertel's theorem and also, how in the presence of non-trivial topology of the magnetic field in the magnetofluid one may associate the linking number of the magnetic field lines with the invariant MHD loads. The paper illustrates that the symmetry translation of the MHD metage in the corresponding label space generates the conservation of cross helicity.Comment: Some issues in the paper are yet to be addressed. Constructive critisicms are most welcom

Sequence Determinants of the Folding Free-Energy Landscape of beta alpha-Repeat Proteins: A Dissertation

The most common structural platform in biology, the βα-repeat classes of proteins, are represented by the (βα)8TIM barrel topology and the α/β/α sandwich, CheY-like topology. Previous studies on the folding mechanisms of several members of these proteins have suggested that the initial event during refolding involves the formation of a kinetically trapped species that at least partially unfolds before the native conformation can be accessed. The simple topologies of these proteins are thought to permit access to locally folded regions that may coalesce in non-native ways to form stable interactions leading to misfolded intermediates. In a pair of TIM barrel proteins, αTS and sIGPS, it has been shown that the core of the off-pathway folding intermediates is comprised of locally connected clusters of isoleucine, leucine and valine (ILV) residues. These clusters of Branched Aliphatic Side Chains (BASiC) have the unique ability to very effectively prevent the penetration of water to the underlying hydrogen bond networks. This property retards hydrogen exchange with solvent, strengthening main chain hydrogen bonds and linking tertiary and secondary structure in a cooperative network of interactions. This property would also promote the rapid formation of collapsed species during refolding. From this viewpoint, the locally connected topology and the appropriate distribution of ILV residues in the sequence can modulate the energy landscapes of TIM barrel proteins. Another sequence determinant of protein stability that can significantly alter the structure and stability of TIM barrels is the long-range main chain-side chain hydrogen bond. Three of these interactions have been shown to form the molecular underpinnings for the cooperative access to the native state in αTS. Global analysis results presented in Chapter II and Chapter III, suggest that the off-pathway mechanism is common to three proteins of the CheY-like topology, namely CheY, NT-NtrC and Spo0F. These results are corroborated by Gō-simulations that are able to identify the minimal structure of kinetically trapped species during the refolding of CheY and Spo0F. The extent of transient, premature structure appears to correlate with the number of ILV side chains involved in a large sequence-local cluster that is formed between the central β-sheet and helices α2, α3 and α4. The failure of Gō-simulations to detect off-pathway species during the refolding of NT-NtrC may reflect the smaller number of ILV side chains in its corresponding hydrophobic cluster. In Chapter IV, comparison of the location of large ILV clusters with the hydrogen exchange protected regions in 19 proteins, suggest that clusters of BASiC residues are the primarily determinants of the stability cores of globular proteins. Although the location of the ILV clusters is sufficient to determine a majority of the protected amides in a protein structure, the extent of protection is over predicted by the ILV cluster method. The survey of 71 TIM barrel proteins presented in Chapter V, suggests that a specific type of long-range main chain-side chain hydrogen bond, termed “βα hairpin clamp” is a common feature in the βα-repeat proteins. The location and sequence patterns observed demonstrate an evolutionary signature of the βαβ modules that are the building blocks of several βα-repeat protein families. In summary, the work presented in this thesis recognizes the role of sequence in modulating the folding free energy landscapes of proteins. The formation of off-pathway folding intermediates in three CheY-like proteins and the differences in the proposed extent of structure formed in off-pathway intermediates of these three proteins, suggest that both topology and sequence play important and concerted roles in the folding of proteins. Locally connected ILV can clusters lead to off-pathway traps, whereas the formation of the productive folding path requires the development of long-range nativelike topological features to form the native state. The ability of ILV clusters to link secondary and tertiary structure formation enables them to be at the core of this cooperative folding process. Very good correlations between the locations of ILV clusters and both strong protection against exchange and the positions of folding nuclei for a variety of proteins reported in the literature support the generality of the BASiC hypothesis. Finally, the discovery of a novel pattern of H-bond interactions in the TIM barrel architecture, between the amide hydrogen of a core ILV residue with a polar side chain, bracketing βαβ modules, suggests a means for establishing cooperativity between different types of side chain interactions towards formation of the native structure. See Additional Files for copies of the source code for the global analysis program and the cluster analysis program

Home Control and Monitoring

Home automation is rapidly growing at present. People need comfort and convenience. In this paper, I give an overview of the home automation through power line communication (PLC) technology. This paper presents an overview of the research, methods, applications, standards and some of the critical features of the power line communication. Powerline communication is one of the most emerging home network technology that allows consumers to use their already existing powerline wires to connect home appliances to each other and the Internet. By using power lines, it the most innovative way to home automation, reducing the congested wifi devices and external cables.B.S. (Bachelor of Science

Effect of shape anisotropy on transport in a 2-dimensional computational model: Numerical simulations showing experimental features observed in biomembranes

We propose a 2-d computational model-system comprising a mixture of spheres and the objects of some other shapes, interacting via the Lennard-Jones potential. We propose a reliable and efficient numerical algorithm to obtain void statistics. The void distribution, in turn, determines the selective permeability across the system and bears a remarkable similarity with features reported in certain biological experiments.Comment: 1 tex file, 2 sty files and 5 figures. To appear in Proc. of StatPhys conference held in Calcutta, Physica A 199

Minimum impact and immediacy of citations to physics open archives of arXiv.org: Science Citation Index based reports

The present work has calculated the minimum Open Archive Impact Factors and Open Archive Immediacy Index for the Physics Classes of arXiv.org as calculated for traditional journals in Journal Citation Reports of the Institute of Scientific Information using Science Citation Index without the citation by the classes itself. The calculated Impact Factors reveal that High-Energy Physics classes of arXiv.org (‘hep-th’, ‘hep-lat’, ‘hep-ex’, and ‘hep-ph’) have made more impact on the scientific community than any other classes except ‘nucl-ex’. The Impact Factors for the year 2003 are: ‘hep-th’ (0.999), ‘nucl-ex’ (0.806), ‘hep-lat’ (0.766), ‘hep-ex’ (0.73), ‘hep-ph’ (0.719), ‘nucl-th’ (0.338), ‘quant-ph’ (0.334), ‘cond-mat’ (0.313), ‘astro-ph’ (0.195), ‘math-ph’ (0.162), ‘physics’ (0.061), and ‘gr-qc’ (0.002). If the period for getting the citations to the open archive classes is considered one year as against two years for journal articles, the rank of the classes is the same. The immediacy of citing the Open Archives is also high for the High-Energy Physics classes. The Immediacy Indexes for the year 2003 are: ‘hep-ex’ (0.619), ‘hep-th’ (0.454), ‘hep-ph’ (0.44), ‘hep-lat’ (0.263), ‘nucl-ex’ (0.238), ‘quant-ph’ (0.202), ‘nucl-th’ (0.185), ‘cond-mat’ (0.168), ‘astro-ph’ (0.094), ‘math-ph’ (0.075), ‘physics’ (0.03), and ‘gr-qc’ (0.002). The impact is definitely much higher than what is concluded from the calculated factors because self-citations are not reckoned in the study. Use of web-tools like ‘Citebase’, ‘Citeseer’ etc. may strengthen the above argument