On boundary logarithmic continuity of mappings of some domains onto domains with a locally quasiconformal boundary

The article is devoted to the study of mappings that satisfy the so-called inverse Poletsky inequality. We consider mappings of quasiextremal distance domains, domains with a locally quasiconformal boundary, and domains which are regular in the sense of prime ends onto domains with a locally quasiconformal boundary, regular domains, or domains which are locally H\"{o}lder equivalent to a half-ball on its boundary. For such mappings, we have obtained the H\"{o}lder logarithmic continuity in some neighborhood of its boundary points.Comment: in Ukrainian languag

Studying of the Polylactide or Polyglycylidactide Surface Layer Biodegradation in Neutral Media for the Subsequent Layered Composite Creation

  The processes of biodegradation in phosphate buffer with pH 7.4 and 0.9 wt.% NaCl of polymer polylactide or polyglycylidactide films for the subsequent creation of a layered composite with a biodegradable layer on the basis of a nickel-free shape memory alloy TiNbTaZr were studied. The structure of the samples was determined by SEM and an optical microscope. For polylactide films the rate of biodegradation did not depend on the mass of the film. A gradual decrease in the rate of biodegradation at any mass with a similar dependence on time is noted. With an increase in the mass of films based on poly(glycolide-lactide) the rate of biodegradation increased. And even at the initial stage the dissolution rate is 2-3 times higher than in pure polylactide. On day 180, complete dissolution of the polyglycolidelactide was observed (even a precipitate was not observed) and completely entire polylactide films, however, lost  their transparency, was noted

Rezul'taty primeneniya preduktala (trimetazidina) u pozhilykh patsientov s refrakternoy stenokardiey, stradayushchikh sakharnym diabetom

Представлены результаты клинического исследования по оценки эффективности добавления триметазидина к монотерапии изосорбида динитратом у пациентов с сахарным диабетом. Указанная терапия позволяла эффективно устранять ишемию миокарда, рефрактерную по отношению к нитропрепаратам. Препарат активно влияет на энергетический метаболизм ишемизированного миокарда, причем - наиболее эффективен в условиях нарушенного углеводного обмена. Отсутствие какой-либо гемодинамической активности значительно улучшает профиль переносимости триметазидина и позволяет считать его идеальным препаратом выбора для лечения пожилых пациентов, предрасположенных к развитию побочных эффектов на фоне традиционной антиангинальной терапии. Метаболический механизм действия, реализующийся на клеточном уровне и не связанный с изменениями гемодинамики, определяет абсолютную аддитивность триметазидина по отношению к традиционным антиангинальным препаратам. Исследование продемонстрировало, что триметазидин можно рекомендовать, в качестве полноценной альтернативы современным методам реваскуляризации миокарда у больных ИБС с такими неблагоприят ными особенностями течения заболевания, как пожилой возраст, наличие СД и рефрактерность стенокардии по отношению к традиционным антиангинальным препаратам

DIAGNOSTIC PROBLEMS OF MUCOVISCIDOSIS AND WAYS OF SOLUTION IN RUSSIA

Mucoviscidosis is a monogenic autosomal recessive caused by the CFTR gene mutations and characterized by pronounced genetic heterogeneity and clinical polymorphism, which emphasizes the need in comprehensive diagnosis and molecular-genetic verification of the final diagnosis. Quality and duration of a mucoviscidosis patient depend on early diagnosis and timely adequate therapy. The article presents mucoviscidosis diagnostic methods and protocols and capabilities of the modern molecular-genetic pathological diagnosis; a review of DNA diagnostic sets has been performed. As sets of some of the genes typical to the Russian population have not been registered in the Russian Federation, mutations in 20% of the patients cannot be specified. In order to solve this problem it is necessary to develop DNA diagnostic sets specific for the Russian Federation, ensure genetic diagnosis of the disease, including sequencing methods at the expense of the federal budget, increase the amount of information and improve quality of teaching this discipline to  students of medial universities and at postgraduate courses for appropriate specialists