Pharmacoeconomic effectiveness of phytotherapy in complex treatment of pyelonephritis

We conducted pharmacoeconomic analysis of comprehensive treatment using herbal tea "Baikalskiy-6" and conventional therapy in patients with acute and chronic pyelonephritis. The relation "cost - effectiveness" was investigated. Using herbal medicine increases the effectiveness of treatment, prolongs relapse-free period, reduces the number of recurrences of infection in the long-term period. The relation "cost - effectiveness" in the treatment of patients with the use of phytotherapy assets during the year by 36,6% lower than just a course of antibiotic therapy during exacerbations. Using herbal medicine in treatment of patients with acute and chronic pyelonephritis increases the duration of disease-free period and reduces the number of recurrences of urinary infection during the year

Optimization of diagnostics and treatment of maxilla-facial area phlegmons (literature review)

Maxillo-facial area phlegmon is a common, serious, costly and deadly disease. Over the last decade, the attention of researches and clinical was focused on the search the optimal methods of diagnosis and treatment of this pathology. It is necessary for timely initiation of adequate causal antibiotic therapy and prevention of complications. Gas chromatography - mass-spectrometry is one of the most powerful analytical methods to obtain data on the exciter. The review highlights the current understanding of the role and potential of the method in the improvement of measures aimed at prevention and treatment of phlegmons and their complications

Microbial landscape patients with advanced sterile pancreatic necrosis in the dynamics of complex treatment

Method of gas chromatography - mass spectrometry was used for the study of microbial landscape of patients with pancreatonecrosis. It was found that the provision of sterile necrotic destruction dysbiosis occurs that requires correction during the treatment. Unlike conventional methods of diagnosis of infection pancreatogenic gas chromatography - mass spectrometry allows to express mode (3 hours) monitored landscape microbial degradation pancreatogenic patients. In patients with necrotizing pancreatitis concentration of organisms was determined in serum on admission, on day 5, day 10, day 15, day 20 of treatment. Data on the composition of microorganisms, participants of widespread sterile necrotic destruction when assessing the overall microecological status, obtained for each patient allow to get a qualitatively new comprehensive information to make adequate antibiotic therapy and complex treatment that significantly broadens the etiology of this disease

PANCREATODUODENAL RESECTION IN THE TREATMENT OF CHRONIC PANCREATITIS AND PANCREATIC CANCER

A clinical analysis of 51 patient treated, in surgical ward of Republican. Clinical Hospital named, after N.A. Semashko during the period, of 1993—2011. All patients had. pancreatoduodenal resection for chronic pancreatitis (7) and pancreatic cancer (44). In the nearest postoperative period, mortality was 7,8 %. In the remote postoperative period, terms of survivability in 8 patients with cancer were 18—34 months. One patient lived 10 years

Microbial landscape of operated patients with limited sterile pancreatic necrosis in different periods of complex treatment

The method of gas chromatography - mass spectrometry was studied for the first time in patients with sterile pancreatic necrosis. The parameters defined in the normal conditions are presented. We studied the microbial landscape of patients with sterile pancreatic necrosis in the dynamics of complex treatment. Qualitative analysis was based on the comparison of retention times and mass specter of the total corresponding pure compounds using a library of standard data and mixtures N1ST08.L. We detected elevated markers in patients with acute pancreatitis associated with anaerobic microflora (peptostreptococcus, staphylococci, eubacteria, fusobacterium, clostridium), and at the same time low level of lactobacilli, bifidobacteria, some ruminococcus, actinomycetes and other microorganisms that caused dysbiosis

Microbial landscape of patients with limited sterile pancreatic necrosis (non-operated) in the different periods of treatment

Method of gas chromatography - mass spectrometry was used for the study of patients with microbial landscape pancreatonecrosis. In patients with necrotizing pancreatitis concentration of organisms was determined in serum at the admission to the hospital, in the middle of the treatment and at discharge. Increased concentrations of Helicobacter pylori, Herpes, anaerobic bacteria were detected in the blood serum of patients with limited sterile pancreatic necrosis who had medical diagnostic laparoscopy. This fact, in our opinion, extends the etiology of this disease. We found that patients with pancreatic necrosis has limited sterile dysbiosis, which can be adjusted over time by gas chromatography - mass spectrometry

The effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study

Introduction. Epidural fibrosis is an urgent problem in modern spinal surgery and orthopedics. The formation of connective tissue in the epidural space after performing surgical interventions on the spinal column inevitably leads to adhesion of the latter to the dura mater and compression of neural structures, followed by the formation of clinical and neurological symptoms. The  search for literary sources in domestic and foreign scientific databases has demonstrated the presence of several works studying the effectiveness of barrier methods for preventing the development of epidural fibrosis. It should be noted that the results of these studies are ambiguous and largely contradictory.The purpose was to study the effectiveness of using a spatially cross-linked polymer in the postoperative lumbar epidural fibrosis prevention in an experiment.Materials and methods. The study included 26 male Wistar rats (average body weight 338.5±9.07 g), which were divided into two groups: Group I (control, n = 12): animals underwent laminectomy at the level of vertebral bodies LVII – SI  without application of spatially crosslinked polymer; Group II (experimental, n = 14): animals underwent laminectomy at the level of vertebral bodies LVII – SI  followed by application of a spatially cross-linked polymer to the dura mater. The morphological and instrumental parameters were studied.Results. Significant differences were noted in the severity of epidural fibrosis (χ2 = 14.846, p = 0.003), the number of newly formed vessels (F = 14.371, p<0.001), the number of fibroblasts (F = 11.158, p<0.001), as well as in the severity of vertebral stenosis channe l according to multislice computed tomography (χ2 = 17.207, p=0.002) between the control and experimental groups of animals.Conclusion. Application of a spatially cross-linked polymer to the dura mater is an effective way to prevent the development of postoperative epidural fibrosis