APP_cycling Tor Bella Monaca

The regeneration of the Tor Bella Monaca district is an issue that cannot be faced ignoring the social, environmental and technological evidence that nowadays concerns most of the Italian or international peripheral settlements. The APP_ cycling proposal intends not only to overturn the marginal condition of empty spaces, relocating them at the center of the dynamics related to the suburban living. The project also seize the challenge of intervening not with specific solutions, but on the entire socio-technical-environmental system of the study area. As regards to the first aspect, we operate through regenerative, coherent and integrated activities, without separations between the general urban system, open spaces, infrastructures and interventions that support inhabitants. Concerning the second aspect, pre-feasibility is interpreted not as a closed and predetermined technical act, but as a projection of transversal scenarios that involve multiple problematic levels, different families of interventions and multiple solutions. The proposal responds to the pre-feasibility challenge by proposing a project-process that mediates between strategic, tactical and operational interventions. In this way, more co-evolutionary visions are determined, relying on open opportunities, to reconnect in a regenerative sense the different technical-environmental, socio-economic and cultural entities that today are ignored or are conflicting, but tomorrow they could become fundamental for a new model of coexistence in the urban suburbs

Effects of different membranes and dialysis technologies on patient treatment tolerance and nutritional parameters

There is increasing evidence that the biochemical and cellular phenomena induced by blood/membrane/dialysate interactions contribute to dialysis-related intradialytic and long-term complications. However, there is a lack of large, prospective, randomized trials comparing biocompatible and bioincompatible membranes, and convective and diffusive treatment modalities. The primary aim of this prospective, randomized trial was to evaluate whether the use of polysulfone membrane with bicarbonate dialysate offers any advantages (in terms of treatment tolerance, nutritional parameters and pre-treatment beta(2)-microglobulin levels) over a traditional membrane (Cu-prophan(R)). A secondary aim was to assess whether the use of more sophisticated methods consisting of a biocompatible synthetic membrane with different hydraulic permeability at different ultrafiltration rate (high-flux hemodialysis and hemodiafiltration) offers any further advantages. Seventy-one Centers were involved and stratified according to the availability of only the first two or all four of the following techniques: Cuprophan(R) hemodialysis (Cu-HD), low flux polysulfone hemodialysis (LfPS-HD), high-flux polysulfone high-flux hemodialysis (HfPS-HD), and high-flux polysulfone hemodiafiltration (HfPS-HDF). The 380 eligible patients were randomized to one of the two or four treatments (132 to Cu-HD, 147 to LfPS-HD, 51 to HfPS-HD and 50 to HfPS-HDF). The follow-up was 24 months. No statistical difference was observed in the algebraic sum of the end points between bicarbonate dialysis with Cuprophan(R) or with low-flux polysulfone, or among the four dialysis methods under evaluation. There was a significant decrease in pre-dialysis plasma beta(2)-microglobulin levels in high-flux dialysis of 9.04+/-10.46 mg/liter (23%) and in hemodiafiltration of 6.35+/-12.28 mg/liter (16%), both using high-flux polysulfone membrane in comparison with Cuprophan(R) and low-flux polysulfone membranes (P=0.032). The significant decrease in pre-dialysis plasma beta(2)-microglobulin levels could have a clinical impact when one considers that beta(2)-microglobulin accumulation and amyloidosis are important long-term dialysis-related complications