Efficacy of antibiotic therapy in urogenous reactive arthritis and peripheral variant of ankylosing spondyloarthritis

Objective. To study efficacy of antibiotics from two different groups - asitromycin/sumamed (macrolid) and lomefloxacine/maxaquine (ftorquinolone) in urogenous rheactive arthritis (URA) and peripheral variant of ankylosing spondyloarthritis (PVAS) with signs of urogenital Chlamidia inflammation. Material and methods. 86 pts were examined: 51 with URA (including Reiter’s disease - RD) and 35 with PVAS. Diagnoses of URA, RD and PVAS were definite in all pts. 43 pts received sumamed in total dose of I5g, 43 - maxaquinum - 24g total. Treatment efficacy was assessed according to clinical and laboratory indices changes immediately after the end of treatment and then in 1 and 3 months. Results. Similar significant decrease of swollen and tender joint counf as well as laboratory activity indices accompanied by disappearance of urogenital inflammation signs was seen in URA and PVAS. Conclusion. Antibiotics administration for chlamidiosis is indicated in all cases of URA and PVAS with urogenital inflammation signs

Chlamydial infection in rheumatic diseases

19 pts with reactive arthritis of urogenital origin, 3 with ankylosing spondylitis, 4 with undifferentiated spondyloarthritis, 4 with psoriatic arthritis and 8 with rheumatoid arthritis were included. Synovial tissue biopsies obtained during arthroscopy of 37 knee and 1 shoulder joints were examined by method of isolation in McCoy cell culture to reveal viable Chlamydia trachomatis. Chlamydia was isolated in 16 from 38 synovial tissue biopsies in all nosologic forms of arthritis except ankylosing spondylitis. In most cases Chlamydia isolation from synovial tissue coincided with presence of urogenital chlamydiosi