35 research outputs found
MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosis
Aim. To assess the level of microRNA (miR) -21, -22, -126, -221 in patients with coronary artery disease (CAD) with borderline coronary artery stenosis depending on comorbidities and sex.Material and methods. We examined 37 patients with class 1-3 stable CAD aged 49-59 years with borderline (40-70%) coronary artery stenosis. The relative level of miRNA was determined using real-time polymerase chain reaction. Statistical analysis was performed using the non-parametric Mann-Whitney U-test. P<0,05 were considered statistically significant. Results. The miR-221 level was higher in the group of patients with stable CAD with borderline coronary artery stenosis with a metabolically unhealthy obesity (MUO) phenotype, but without diabetes (p=0,042). The level of miR-22 and miR-126 was higher in the group of patients with stable CAD phenotype with borderline stenosis and diabetes (p=0,007 and p=0,034, respectively). The analysis of miR levels in stable CAD patients depending on sex, without taking into account the phenotype, found that miR-21 and miR-221 values were higher in men (p=0,021 and p=0,014, respectively). The study of the sex characteristics of miR content in relation to different phenotypes revealed an increase of miR22 levels in men with MUO and diabetes (p=0,048) and an increase of miR-126 levels in women with concomitant diabetes in the comparison both with patients without MUO and diabetes (p=0,018), as well as with MUO and without diabetes (p=0,007). Conclusion. The study of the miRNA level in patients with CAD with borderline coronary artery stenosis is of great interest and reflects a promising direction in diagnosis based on comorbid pathology. Keywords: miRNA, obesity phenotypes, coronary artery disease, borderline coronary artery stenosis. Relationships and Activities: none. 1Novosibirsk State Medical University, Novosibirsk; 2Federal Research Center of Fundamental and Translational Medicine, Novosibirsk; 3E.N. Meshalkin National Medical Research Center, Novosibirsk, Russia.><0,05 were considered statistically significant.Results. The miR-221 level was higher in the group of patients with stable CAD with borderline coronary artery stenosis with a metabolically unhealthy obesity (MUO) phenotype, but without diabetes (p=0,042). The level of miR-22 and miR-126 was higher in the group of patients with stable CAD phenotype with borderline stenosis and diabetes (p=0,007 and p=0,034, respectively). The analysis of miR levels in stable CAD patients depending on sex, without taking into account the phenotype, found that miR-21 and miR-221 values were higher in men (p=0,021 and p=0,014, respectively). The study of the sex characteristics of miR content in relation to different phenotypes revealed an increase of miR22 levels in men with MUO and diabetes (p=0,048) and an increase of miR-126 levels in women with concomitant diabetes in the comparison both with patients without MUO and diabetes (p=0,018), as well as with MUO and without diabetes (p=0,007).Conclusion. The study of the miRNA level in patients with CAD with borderline coronary artery stenosis is of great interest and reflects a promising direction in diagnosis based on comorbid pathology
Triple coalescence singularity in a dynamical atomic process
We show that the high energy limit for the amplitude of the double electron
capture to the bound state of the Coulomb field of a nucleus with emission of a
single photon is determined by behavior of the wave function in the vicinity of
the singular triple coalescence point.Comment: 3 page
Atrial fibrillation and arterial hypertension in hypothyroid pathology
A special role in the formation of atrial fibrillation in patients with arterial hypertension is played by diseases of the thyroid gland. In any form of hypothyroidism, vascular tone increases, hypervolemia is formed, which leads to changes in blood pressure, myocardial dystrophy and the development of AF. The development and progression of AF affects the lack of thyroid hormones: TH suppresses aldosterone synthesis and stimulates the secretion of atrial and cerebral natriuretic peptide. Therefore, hypothyroidism develops hyperaldosteronism and decreases the content of natriuretic hormone in the blood, which leads to hypervolemia. Atrophic processes in cardiomyocytes are exacerbated by intracellular potassium deficiency, which is caused by hyper aldosteronism characteristic of all types of hypothyroidism. TG plays the role of physiological antagonists of antidiuretic hormone, and their deficiency leads to increased water reabsorption and increases the likelihood of the formation of a volume-dependent form of hypertension, the effect on the endothelium of the cell, releasing vasoactive substances and reducing the sensitivity of adrenoreceptors to the action of catecholamines. In hypothyroidism, almost all soft tissues, including the vascular wall, accumulate in an excessive amount of glycosaminoglycans, which binds sodium ions and water, which leads to swelling of the vascular wall, reduction of nitric oxide production and narrowing of the lumen of arteries and veins. Hyperproduction of thyroliberin, which leads to a decrease in dopaminergic activity of the brain. In addition, hypothyroidism causes thickening of the basement membrane of capillaries and the diffusion of oxygen through their wall is disturbed. The effect of hypothyroidism and drugs used in its treatment on AF is ambiguous. The authors disagree about the course of AF and the frequency of relapse, the risk of complications of AF. All this indicates the need to continue research in this direction.Π ΡΡΠ°ΡΡΠ΅ ΠΈΠ·Π»ΠΎΠΆΠ΅Π½ ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ, ΠΎΡΡΠ°ΠΆΠ°ΡΡΠΈΠΉ ΠΏΡΠ΅ΡΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΠΈ Π³ΠΈΠΏΠΎΡΠΈΡΠ΅ΠΎΠΈΠ΄Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠΈ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ. ΠΎΡΠΎΠ±ΡΡ ΡΠΎΠ»Ρ Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠΈ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠΎΠ½ΠΈΠ΅ΠΉ ΠΈΠ³ΡΠ°ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ. ΠΡΠΈ Π»ΡΠ±ΠΎΠΉ ΡΠΎΡΠΌΠ΅ Π³ΠΈΠΏΠΎΡΠΈΡΠ΅ΠΎΠ·Π° ΠΏΠΎΠ²ΡΡΠ°Π΅ΡΡΡ ΡΠΎΡΡΠ΄ΠΈΡΡΡΠΉ ΡΠΎΠ½ΡΡ, ΡΠΎΡΠΌΠΈΡΡΠ΅ΡΡΡ Π³ΠΈΠΏΠ΅ΡΠ²ΠΎΠ»Π΅ΠΌΠΈΡ, ΡΡΠΎ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ, Π΄ΠΈΡΡΡΠΎΡΠΈΠΈ ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π° ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠΈ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ. ΠΠ° ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π€Π Π²Π»ΠΈΡΠ΅Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΠΊ Π³ΠΎΡΠΌΠΎΠ½ΠΎΠ² ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ: ΡΠΈΡΠ΅ΠΎΠΈΠ΄Π½ΡΠ΅ Π³ΠΎΡΠΌΠΎΠ½Ρ ΠΏΠΎΠ΄Π°Π²Π»ΡΡΡ ΡΠΈΠ½ΡΠ΅Π· Π°Π»ΡΠ΄ΠΎΡΡΠ΅ΡΠΎΠ½Π° ΠΈ ΡΡΠΈΠΌΡΠ»ΠΈΡΡΡΡ ΡΠ΅ΠΊΡΠ΅ΡΠΈΡ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄Π½ΠΎΠ³ΠΎ ΠΈ ΡΠ΅ΡΠ΅Π±ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π½Π°ΡΡΠΈΠΉΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠ΅ΠΏΡΠΈΠ΄Π°. ΠΠΎΡΡΠΎΠΌΡ ΠΏΡΠΈ Π³ΠΈΠΏΠΎΡΠΈΡΠ΅ΠΎΠ·Π΅ ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ Π³ΠΈΠΏΠ΅ΡΠ°Π»ΡΠ΄ΠΎΡΡΠ΅ΡΠΎΠ½ΠΈΠ·ΠΌ ΠΈ ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π² ΠΊΡΠΎΠ²ΠΈ Π½Π°ΡΡΠΈΠΉΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π³ΠΎΡΠΌΠΎΠ½Π°, ΡΡΠΎ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π³ΠΈΠΏΠ΅ΡΠ²ΠΎΠ»Π΅ΠΌΠΈΠΈ. ΠΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ Π² ΠΊΠ°ΡΠ΄ΠΈΠΎΠΌΠΈΠΎΡΠΈΡΠ°Ρ
ΡΡΡΠ³ΡΠ±Π»ΡΡΡΡΡ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ Π΄Π΅ΡΠΈΡΠΈΡΠΎΠΌ ΠΊΠ°Π»ΠΈΡ, ΠΊΠΎΡΠΎΡΡΠΉ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ Π³ΠΈΠΏΠ΅ΡΠ°Π»ΡΠ΄ΠΎΡΡΠ΅ΡΠΎΠ½ΠΈΠ·ΠΌΠΎΠΌ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠΌ Π΄Π»Ρ Π²ΡΠ΅Ρ
Π²ΠΈΠ΄ΠΎΠ² Π³ΠΈΠΏΠΎΡΠΈΡΠ΅ΠΎΠ·Π°. Π’Π Π²ΡΠΏΠΎΠ»Π½ΡΡΡ ΡΠΎΠ»Ρ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π½ΡΠ°Π³ΠΎΠ½ΠΈΡΡΠΎΠ² Π°Π½ΡΠΈΠ΄ΠΈΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π³ΠΎΡΠΌΠΎΠ½Π°,Π° ΠΈΡ
Π΄Π΅ΡΠΈΡΠΈΡ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΡΠΈΠ»Π΅Π½ΠΈΡ ΡΠ΅Π°Π±ΡΠΎΡΠ±ΡΠΈΠΈ Π²ΠΎΠ΄Ρ ΠΈ ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΡΠ΅ΠΌΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΡΠΎΡΠΌΡ ΠΠ, Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠΉ ΠΊΠ»Π΅ΡΠΊΠΈ, Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π°ΡΡΠΈΠΉ Π²Π°Π·ΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²Π° ΠΈ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π°Π΄ΡΠ΅Π½ΠΎΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² ΠΊ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΠ°ΡΠ΅Ρ
ΠΎΠ»Π°ΠΌΠΈΠ½ΠΎΠ². ΠΡΠΈ Π³ΠΈΠΏΠΎΡΠΈΡΠ΅ΠΎΠ·Π΅ ΠΏΠΎΡΡΠΈ Π²ΠΎ Π²ΡΠ΅Ρ
ΠΌΡΠ³ΠΊΠΈΡ
ΡΠΊΠ°Π½ΡΡ
, Π²ΠΊΠ»ΡΡΠ°Ρ ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ ΡΡΠ΅Π½ΠΊΡ, Π½Π°ΠΊΠ°ΠΏΠ»ΠΈΠ²Π°ΡΡΡΡ Π² ΠΈΠ·Π±ΡΡΠΎΡΠ½ΠΎΠΌ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅ Π³Π»ΠΈΠΊΠΎΠ·Π°ΠΌΠΈΠ½ΠΎΠ³Π»ΠΈΠΊΠ°Π½Ρ, ΠΊΠΎΡΠΎΡΡΠΉ ΡΠ²ΡΠ·ΡΠ²Π°Π΅Ρ ΠΈΠΎΠ½Ρ Π½Π°ΡΡΠΈΡ ΠΈ Π²ΠΎΠ΄Ρ, ΡΡΠΎ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΎΡΠ΅ΠΊΡ ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΡΠ΅Π½ΠΊΠΈ, ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ ΠΎΠΊΡΠΈΠ΄Π° Π°Π·ΠΎΡΠ° ΠΈ ΡΡΠΆΠ΅Π½ΠΈΡ ΠΏΡΠΎΡΠ²Π΅ΡΠ° Π°ΡΡΠ΅ΡΠΈΠΉ ΠΈ Π²Π΅Π½. ΠΠΈΠΏΠ΅ΡΠΏΡΠΎΠ΄ΡΠΊΡΠΈΡ ΡΠΈΡΠ΅ΠΎΠ»ΠΈΠ±Π΅ΡΠΈΠ½Π°, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π΄ΠΎΡΠ°ΠΌΠΈΠ½Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°. ΠΊΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΏΡΠΈ Π³ΠΈΠΏΠΎΡΠΈΡΠ΅ΠΎΠ·Π΅ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ ΡΡΠΎΠ»ΡΠ΅Π½ΠΈΠ΅ Π±Π°Π·Π°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΊΠ°ΠΏΠΈΠ»Π»ΡΡΠΎΠ² ΠΈ Π½Π°ΡΡΡΠ°Π΅ΡΡΡ Π΄ΠΈΡΡΡΠ·ΠΈΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° ΡΠ΅ΡΠ΅Π· ΠΈΡ
ΡΡΠ΅Π½ΠΊΡ. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π³ΠΈΠΏΠΎΡΠΈΡΠ΅ΠΎΠ·Π° ΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ
ΠΏΡΠΈ Π΅Π³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΠΈ, Π½Π° Π€Π Π½Π΅ΠΎΠ΄Π½ΠΎΠ·Π½Π°ΡΠ½ΠΎ. Π°Π²ΡΠΎΡΡ ΡΠ°ΡΡ
ΠΎΠ΄ΡΡΡΡ Π²ΠΎ ΠΌΠ½Π΅Π½ΠΈΠΈ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π€Π ΡΠ°ΡΡΠΎΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΎΠ², ΡΠΈΡΠΊΠ° Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π€Π. ΠΡΠ΅ ΡΡΠΎ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ΅Π½ΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π² Π΄Π°Π½Π½ΠΎΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ
Measurement of the 1s-2s energy interval in muonium
The 1s-2s interval has been measured in the muonium ({}) atom by Doppler-free two-photon laser spectroscopy. The frequency separation of the states was determined to be 2 455 528 941.0(9.8)~MHz in good agreement with quantum electrodynamics. The muon-electron mass ratio can be extracted and is found to be 206.768 38(17). The result may be interpreted as measurement of the muon-electron charge ratio as
COMPARISON OF ENALAPRIL AND PERINDOPRIL IN PATIENTS WITH ARTERIAL HYPERTENSION AND LEFT VENTRICLE SYSTOLIC DYSFUNCTION
Aim. To compare efficacy of enalapril and perindopril in patients with arterial hypertension (HT) and left ventricle systolic dysfunction.Material and methods. Patients (n=51) with HT and left ventricle systolic dysfunction (ejection fraction<45%) were included in the prospective open randomized comparative study. Patients were randomized into 2 groups of therapy with enalapril 10-20 mg BID (n=25) or with perindopril 4-8 mg OD (n=26). Hydrochlorothiazide (12,5-25 mg OD) was added in case of ineffective therapy. Routine clinical examination, ambulatory blood pressure (BP) monitoring, an electrocardiogram, an echocardiography were performed in all patients.Results. The 24-hour and night antihypertensive effect of enalapril was more prominent than this of perindopril. Target BP level was reached in 21 patients (84%) of enalapril group and in 20 patients (76,9%) of perindopril group. 8 (30,8%) patients of perindopril group did not reach night target BP level vs 3 (12%) patients of enalapril group. Similar improvement of the left ventricle systolic function was observed in both groups.Conclusion. Enalapril and perindopril demonstrated comparable antihypertensive and cardioprotective effect