43,466 research outputs found

    The ubiquitin-proteasome pathway in cancer.

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    Degradation by the 26S proteasome of specific proteins that have been targeted by the ubiquitin pathway is the major intracellular non-lysosomal proteolytic mechanism and is involved in a broad range of processes, such as cell cycle progression, antigen presentation and control of gene expression. Recent work, reviewed here, has shown that this pathway is often the target of cancer-related deregulation and can underlie processes, such as oncogenic transformation, tumour progression, escape from immune surveillance and drug resistance

    Effects of Scale-Free Disorder on the Anderson Metal-Insulator Transition

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    We investigate the three-dimensional Anderson model of localization via a modified transfer-matrix method in the presence of scale-free diagonal disorder characterized by a disorder correlation function g(r)g(r) decaying asymptotically as rαr^{-\alpha}. We study the dependence of the localization-length exponent ν\nu on the correlation-strength exponent α\alpha. % For fixed disorder WW, there is a critical αc\alpha_{\rm c}, such that for α<αc\alpha < \alpha_{\rm c}, ν=2/α\nu=2/\alpha and for α>αc\alpha > \alpha_{\rm c}, ν\nu remains that of the uncorrelated system in accordance with the extended Harris criterion. At the band center, ν\nu is independent of α\alpha but equal to that of the uncorrelated system. The physical mechanisms leading to this different behavior are discussed.Comment: submitted to Phys. Rev. Let

    Spin ice in a field: quasi-phases and pseudo-transitions

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    Thermodynamics of the short-range model of spin ice magnets in a field is considered in the Bethe - Peierls approximation. The results obtained for [111], [100] and [011] fields agrees reasonably well with the existing Monte-Carlo simulations and some experiments. In this approximation all extremely sharp field-induced anomalies are described by the analytical functions of temperature and applied field. In spite of the absence of true phase transitions the analysis of the entropy and specific heat reliefs over H-T plane allows to discern the "pseudo-phases" with specific character of spin fluctuations and define the lines of more or less sharp "pseudo-transitions" between them.Comment: 18 pages, 16 figure

    Critical Behaviour of 3D Systems with Long-Range Correlated Quenched Defects

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    A field-theoretic description of the critical behaviour of systems with quenched defects obeying a power law correlations xa\sim |{\bf x}|^{-a} for large separations x{\bf x} is given. Directly for three-dimensional systems and different values of correlation parameter 2a32\leq a \leq 3 a renormalization analysis of scaling function in the two-loop approximation is carried out, and the fixed points corresponding to stability of the various types of critical behaviour are identified. The obtained results essentially differ from results evaluated by double ϵ,δ\epsilon, \delta - expansion. The critical exponents in the two-loop approximation are calculated with the use of the Pade-Borel summation technique.Comment: Submitted to J. Phys. A, Letter to Editor 9 pages, 4 figure

    Storage of light in atomic vapor

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    We report an experiment in which a light pulse is decelerated and trapped in a vapor of Rb atoms, stored for a controlled period of time, and then released on demand. We accomplish this storage of light by dynamically reducing the group velocity of the light pulse to zero, so that the coherent excitation of the light is reversibly mapped into a collective Zeeman (spin) coherence of the Rb vapor

    Use of a Granulocyte Immunofluorescence Assay Designed for Humans for Detection of Antineutrophil Cytoplasmic Antibodies in Dogs with Chronic Enteropathies

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    Perinuclear antineutrophil cytoplasmic antibodies (pANCA) previously have been shown to be serum markers in dogs with chronic enteropathies, with dogs that have food‐responsive disease (FRD) having higher frequencies of seropositivity than dogs with steroid‐responsive disease (SRD). The indirect immunofluorescence (IIF) assay used in previous publications is time‐consuming to perform, with low interobserver agreement. Forty‐four dogs with FRD, 20 dogs with SRD, 20 control dogs, and 38 soft‐coated wheaten terrier (SCWT) or SCWT‐cross dogs
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