On the safety of acetaminophen

Acetaminophen is one of the most commonly used analgesics /anti pyretics. However, taking into account the existing risk of hepatotoxicity,regulatory bodies of a number of the countries made additional adjustments tothe recommendations on the use of this drug. In the article the possible reasonsfor recourse to acetaminophen are discusse

THE EFFICACY AND SAFETY PROFILE OF ADVANCED THERAPY MEDICINAL PRODUCTS IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION

Age-related macular degeneration is the main cause of loss of sight in the world. This review presents a current view on modern drugs used for the treatment of macular degeneration. A comparison effectiveness and safety profile of bevacizumab, ranibizumab, and pegaptanib aflibercept enables us to conclude that each of these compounds has its own advantages and disadvantages. Further study will develop rational schemes of their application

Off - label use of drugs - important problem of modern pharmacotherapy

Marketing authorization for a drug is granted to the holder according to the results of pre - clinical and clinical studies and positive benefit - risk assessment. However, sometimes healthcare specialists prescribe drugs for off-label purposes. Off-label use of drugs may be associated with increased risk of serious adverse drug reactions, including death. In this article you may find pharmacoepidemiology of adverse drug reactions caused by off-label use of medicines and legal framework on the subject.Разрешение на применение лекарственных средств в медицинской практике выдается на основании результатов доклинических и клинических исследованиях, подтверждающих их эффективность и безопасность, а также при представлении доказательств того, что польза от их использования превышает возможные риски. Однако в практической медицине нередко имеют место ситуации, при которых врач назначает лекарственные препараты с нарушением предписаний инструкции, что может быть ассоциировано с риском развития серьезных, в том числе летальных нежелательных реакций (НР). В данной статье приводятся результаты фармакоэпидемиологического исследования НР, вызванных использованием препаратов с нарушением предписаний инструкции, а также анализ нормативно - правовой базы по данному вопросу

USE OF DRUGS DURING THE FIRST TRIMESTER OF PREGNANCY IN TERMS OF FOETUS SAFETY: ANALYSIS OF PRESCRIBINGS

The article presents the results of analysis of the use of drugs in the first trimester of pregnancy from the point of view of safety to the fetu

Qualitative methods of benefit / risk assessment

In this article authors describe some existing methods of benefit / risk assessment

LOCAL ANESTHETIC MYOTOXICITY

The article presents the mechanisms of development and methods of correction of myotoxicity associated with use of local anesthetic

MYOPATHY CAUSED BY THE INTERACTION OF COLCHICINE AND STATINS

Myopathy is a life-threatening disease that can be caused, among other things, by the intake of various medications. Despite the fact  that many drug-induced myopathies are well known, however, many  health professionals are not alert to myopathies caused by drug  interactions. Myopathy is a wellknown adverse reaction of statins,  and muscle damage can range from minor muscle pain and  weakness to life-threatening rhabdomyolysis. Colchicine can also  cause myopathy, including rhabdomyolysis. The combination of  colchicine and statins can significantly increase the risk of myopathy  compared with their intake separately. In cases of development of  myopathy in patients receiving colchicine and statins simultaneously, the most common manifestation of drug interaction was muscle  weakness, occurring in almost every case, and in some cases,  muscle weakness was so severe that the patient lost the ability to  move. In a third of cases, the development of muscle weakness was  accompanied by muscular pain, and darkening of urine to tea shade.  One study showed that 40 % of patients received concurrent combinations of drugs that increased the risk of muscle  damage. It is concluded that the simultaneous administration of  colchicine and statins requires an assessment of the “benefit-risk”  ratio, as well as the administration of drugs in minimally effective doses

EVALUATIONS OF ADVERSE DRUGS REACTIONS IN RUSSIA IN 2013

The article presents the results of pharmacoeconomic studies of adverse reactions to the drugs in Russian Federation

Violation of prescription instructions: a viewpoint of a contemporary

Today drug safety monitoring is a challenge faced by all countries in the world. The reasons for that are the use by modern medical practice of potent drugs, sensibilization of the population to biological and chemical agents, inefficient use of medicines, medical errors and other reasons including use of drugs in violation of directions

COMPARATIVE EVALUATION OF INFORMATION ON ADVERSE REACTIONS TO MEDICINES

Comparative evaluation of information about adverse reactions to medicinal products was carried out on the basis of the research data registered in specialized databases WHO, Russia, Switzerland, USA and the Republic of Kazakhstan. Comparative evaluation of the results of safety monitoring medicines showed that in the Russian Federation the average reporting about adverse reactions below the level recommended by WHO and countries with the most effective system of pharmacovigilance, such as the USA or Switzerland, but higher than in the Republic of Kazakhstan