Two modes of longe-range orientation of DNA bases realized upon compaction.

Formation of compact particles from linear DNA-anthracycline complexes is accompanied by appearance of intense bands in the CD spectra in the region of absorption of DNA bases (UV-region) and in the region of absorption of anthracycline chromophores (visible region). The intense (positive or negative) bands in the region of anthracycline absorption demonstrate an ordered helical location of anthracycline molecules on the DNA template. This fact, in its turn, is related to formation of the DNA superstructure in PEG-containing water-salt solutions with a long-range orientation of nitrogen bases. Possible types of DNA superstructures and the relation between the local- and the long-range order of bases in the DNA superstructure are discussed

Structural DNA Nanotechnology: Liquid-Crystalline Approach

The investigation of DNA-based materials attracts attention of scientists from various laboratories because this is definitely an emerging area in physics, molecular biology, biotechnology, biosensorics, nanobiotechnology as well as in material science. This chapter compares two different approaches in the structural DNA nanotechnology, i.e. ???hybridization??? and ???liquid-crystalline??? approaches. The chapter reviews the state-of-the art in the fundamental studies of liquid-crystalline forms of double-stranded DNA molecules generated as a result of their phase exclusion from polymer-containing water-salt solutions. The results presented in this chapter demonstrate how the fundamental data obtained when studying the physicochemical properties of doublestranded DNA liquid-crystalline dispersions can be used as a background for induction of a ???liquid??? ??? ???rigid??? state transition, i.e. for the design of novel types of ???rigid??? DNA nano-constructions carrying various ???guest??? molecules, which display unique properties of practical importance

Structural DNA Nanotechnology: Liquid-Crystalline Approach

The investigation of DNA-based materials attracts attention of scientists from various Laboratories because this is definitely an emerging area in physics, molecular biology, biotechnology, biosensorics, nanobiotechnology as well as in material science. This book compares two different approaches in the structural DNA nanotechnology, i.e. \u201chybridization\u201d approach and \u201cliquid-crystalline approach\u201d. The book reviews the state-of-the art in the fundamental studies of liquid-crystalline state of double-stranded DNA molecules appeared as a result of their phase exclusion from polymer-containing water-salt solutions. The results presented in this review demonstrate how the fundamental data obtained when studying the physico-chemical properties of doublestranded DNA liquid-crystalline dispersions can be used as a background for induction of a \u201cliquid\u201d- \u201crigid\u201d state transition, i.e. for the design of novel types of \u201crigid\u201d DNA nanoconstructions carrying various \u201cguest\u201d molecules which display unique properties of practical importance