ОСОБЕННОСТИ ДЕТСКОГО РАССЕЯННОГО СКЛЕРОЗА

Введение. Демиелинизующие заболевания – одна из самых актуальных и дискутабельных проблем в неврологии. Несмотря на появление улучшенных диагностических критериев и новых направлений в терапии, рассеянный склероз занимает лидирующее место в инвалидизации молодых пациентов. По данным эпидемиологических исследований, во всем мире рассеянным склерозом страдают около 3 млн человек. При этом от 2,7 до 10,5% всех случаев рассеянного склероза во всем мире наблюдается у детей в возрасте до 18 лет с тенденцией к росту заболеваемости. Цель. Провести анализ результатов научных исследований случаев детского рассеянного склероза. Материал и методы. Проведен качественный анализ русскоязычных и англоязычных источников, содержащих в себе данные о случаях детского рассеянного склероза. Результаты. Установлено, что заболеваемость рассеянным склерозом среди педиатрических пациентов существенно меньше в сравнении со взрослым населением. Клиническая картина полиморфна и в некоторых случаях атипична. Выводы. Cовременное понимание термина «педиатрический рассеянный склероз» указывает на узкое окно начала с отличным от взрослых когнитивным снижением, сочетанное с более высоким числом рецидивов и количеством очагов воспаления по сравнению с взрослым рассеянным склерозом. Полиморфная клиническая картина и атипичные проявления в детском возрасте, а также дебют в виде клинически изолированного синдрома могут затруднять раннюю дифференциальную диагностику и увеличивать промежуток от манифестации заболевания до назначения необходимой фармакотерапии, которая способна снизить тяжесть течения заболевания, частоту рецидивов и увеличить промежуток «дебют – инвалидизация»

Quark and pion condensation in a chromomagnetic background field

The general features of quark and pion condensation in dense quark matter with flavor asymmetry have been considered at finite temperature in the presence of a chromomagnetic background field modelling the gluon condensate. In particular, pion condensation in the case of a constant abelian chromomagnetic field and zero temperature has been studied both analytically and numerically. Under the influence of the chromomagnetic background field the effective potential of the system is found to have a global minimum for a finite pion condensate even for small values of the effective quark coupling constant. In the strong field limit, an effective dimensional reduction has been found to take place.Comment: 17 pages, 6 figure

Chromomagnetic Catalysis of Color Superconductivity in a (2+1)-dimensional NJL Model

The influence of a constant uniform external chromomagnetic field $H$ on the formation of color superconductivity has been investigated. The consideration was performed in the framework of a (2+1)-dimensional Nambu--Jona-Lasinio model with two different four-fermionic structures responsible for $$and diquark$$ condensates. In particular, it was shown that there exists a critical value $H_c$ of the external chromomagnetic field such that at $H>H_c$ a nonvanishing diquark condensate is dynamically created (the so-called chromomagnetic catalysis effect of color superconductivity). Moreover, external chromomagnetic fields may in some cases enhance the diquark condensate of color superconductivity.Comment: 32 pages, 2 figures, revte

Statistical Mechanical Calculation of Anisotropic Step Stiffness of a Two-Dimensional Hexagonal Lattice Gas Model with Next-Nearest-Neighbor Interactions: Application to Si(111) Surface

We study a two-dimensional honeycomb lattice gas model with both nearest- and next-nearest-neighbor interactions in a staggered field, which describes the surface of stoichiometrically binary crystal. We calculate anisotropic step tension, step stiffness, and equilibrium island shape, by an extended random walk method. We apply the results to Si(111) 7$\times$7 reconstructed surface and high-temperature Si(111) 1$\times$1 surface. We also calculate inter-step interaction coefficient.Comment: revised on May 29 1999: RevTeX v3.1, 10 pages with 9 figures (one figure added

The Influence of an External Chromomagnetic Field on Color Superconductivity

We study the competition of quark-antiquark and diquark condensates under the influence of an external chromomagnetic field modelling the gluon condensate and in dependence on the chemical potential and temperature. As our results indicate, an external chromomagnetic field might produce remarkable qualitative changes in the picture of the color superconducting (CSC) phase formation. This concerns, in particular, the possibility of a transition to the CSC phase and diquark condensation at finite temperature.Comment: 27 pages, RevTex, 8 figures; the version accepted for the publication in PRD (few references added; new numerical results added; main conclusions are not changed

Magnetic Oscillations in Dense Cold Quark Matter with Four-Fermion Interactions

The phase structures of Nambu-Jona-Lasinio models with one or two flavours have been investigated at non-zero values of $\mu$ and $H$, where $H$ is an external magnetic field and $\mu$ is the chemical potential. In the phase portraits of both models there arise infinitely many massless chirally symmetric phases, as well as massive ones with spontaneously broken chiral invariance, reflecting the existence of infinitely many Landau levels. Phase transitions of first and second orders and a lot of tricritical points have been shown to exist in phase diagrams. In the massless case, such a phase structure leads unavoidably to the standard van Alphen-de Haas magnetic oscillations of some thermodynamical quantities, including magnetization, pressure and particle density. In the massive case we have found an oscillating behaviour not only for thermodynamical quantities, but also for a dynamical quantity as the quark mass. Besides, in this case we have non-standard, i.e. non-periodic, magnetic oscillations, since the frequency of oscillations is an $H$-dependent quantity.Comment: latex, 29 pages, 8 figure

Magnetic Catalysis: A Review

We give an overview of the magnetic catalysis phenomenon. In the framework of quantum field theory, magnetic catalysis is broadly defined as an enhancement of dynamical symmetry breaking by an external magnetic field. We start from a brief discussion of spontaneous symmetry breaking and the role of a magnetic field in its a dynamics. This is followed by a detailed presentation of the essential features of the phenomenon. In particular, we emphasize that the dimensional reduction plays a profound role in the pairing dynamics in a magnetic field. Using the general nature of underlying physics and its robustness with respect to interaction types and model content, we argue that magnetic catalysis is a universal and model-independent phenomenon. In support of this claim, we show how magnetic catalysis is realized in various models with short-range and long-range interactions. We argue that the general nature of the phenomenon implies a wide range of potential applications: from certain types of solid state systems to models in cosmology, particle and nuclear physics. We finish the review with general remarks about magnetic catalysis and an outlook for future research.Comment: 37 pages, to appear in Lect. Notes Phys. "Strongly interacting matter in magnetic fields" (Springer), edited by D. Kharzeev, K. Landsteiner, A. Schmitt, H.-U. Yee. Version 2: references adde

Pion condensation of quark matter in the static Einstein universe

In the framework of an extended Nambu--Jona-Lasinio model we are studying pion condensation in quark matter with an asymmetric isospin composition in a gravitational field of the static Einstein universe at finite temperature and chemical potential. This particular choice of the gravitational field configuration enables us to investigate phase transitions of the system with exact consideration of the role of this field in the formation of quark and pion condensates and to point out its influence on the phase portraits. We demonstrate the effect of oscillations of the thermodynamic quantities as functions of the curvature and also refer to a certain similarity between the behavior of these quantities as functions of curvature and finite temperature. Finally, the role of quantum fluctuations for spontaneous symmetry breaking in the case of a finite volume of the universe is shortly discussed.Comment: RevTex4; 15 pages, 10 figure