Donor to recipient age matching in lung transplantation: A European experience

\ua9 2024 The AuthorsBackground: The age profile of organ donors and patients on lung transplantation (LT) waiting lists have changed over time. In Europe, the donor population has aged much more rapidly than the recipient population, making allocation decisions on lungs from older donors common. In this study we assessed the impact of donor and recipient age discrepancy on LT outcomes in the UK and France. Methods: A retrospective analysis of all adult single or bilateral LT in France and the UK between 2010 and 2021. Recipients were stratified into 3 age author groups: young (≤30 years), middle-aged (30–60) and older (≥60). Their donors were also stratified into 2 groups <60, ≥60. Primary graft dysfunction (PGD) rates and recipient survival was compared between matched and mismatched donor and recipient age groups. Propensity matching was employed to minimize covariate imbalances and to improve the internal validity of our results. Results: Our study cohort was 4,696 lung transplant recipients (LTRs). In young and older LTRs, there was no significant difference in 1 and 5-year post-transplant survival dependent on the age category of the donor. Young LTRs who received older donor grafts had a higher risk of severe grade 3 PGD. Conclusion: Our findings show that clinically usable organs from older donors can be utilized safely in LT, even for younger recipients. Further research is needed to assess if the higher rate of PGD3 associated with use of older donors has an effect on long-term outcomes

Remèdes traditionnels à base d’aristoloches et de bryone dioïque dans le Maroc oriental : risque d’intoxication des populations exposées

editorial reviewe

Numérisation et analyse des cartes piscicoles historiques. Action 8 : évolution des aires de répartition des espèces. Rapport final. Convention Cemagref-ONEMA. Partenariat 2010

[Departement_IRSTEA]Eaux [TR1_IRSTEA]QUASAR

Actualisation des indications et contre-indications à la transplantation pulmonaire en 2022

International audienc

L’assistance extracorporelle en bridge à la transplantation pulmonaire en urgence pour les patients avec une atteinte pulmonaire rapidement progressive d’une dermatomyosite anti-MDA5

International audienc