Legitimation of University in Modern Culture

The authors propose to consider university as a significant cultural topos. The significance of the topos is provided by the narrative integrated in it. It reflects the values and inscribes the university into the current cultural situation. The authors give several historical examples to support their thesis that this narrative is a response to external cultural challenges. The current situation is rife with such challenges, and therefore, the creation of a legitimizing narrative for the university turns out to be quite problematic. The authors study the influence of such factors as massification of education, media communication, social, demographic changes, etc. Examples of modern Russian and foreign universities demonstrate self-legitimization process of the university and show its visual part. The universities represent their own position, history and current values by creating their own visual code. The authors adduce as examples modern universities’ websites with the visual images that are presented on their title pages. Based on this material, the authors draw a conclusion about the main modern strategies of self-legitimation of the university as positioning on the scales: tradition and innovation, loyalty to the government and independence from it, history and community

СРАВНИТЕЛЬНЫЙ АНАЛИЗ ЭФФЕКТИВНОСТИ КОНТРОЛИРУЕМЫХ И ДОМАШНИХ ФИЗИЧЕСКИХ ТРЕНИРОВОК АМБУЛАТОРНОГО ЭТАПА РЕАБИЛИТАЦИИ ПОСЛЕ КОРОНАРНОГО ШУНТИРОВАНИЯ

The purpose. To assess the impact of the three-month supervised and home-based physical trainings in the outpatient cardiac rehabilitation program on exercise tolerance and double product in patients undergoing coronary artery bypass grafting (CABG).Material and methods: 114 male patients of working age with coronary artery disease (CAD) who have undergone CABG were examined. Patients were enrolled into three groups: Group 1 − patients undergoing supervised cycling trainings (SCT) (n = 36), Group 2 − patients undergoing home-based trainings (HBT) (n = 36) and the control group without any exercise trainings (n = 42). The following parameters were assessed: the six-minute walk test (6MWT) value, exercise tolerance (ET) and double product (DP), determined by the cycle ergometer test (CET) prior to surgery, 1, 4 months and 1 year after CABG.Results: The 6MWT value increased by 9% in the SCT group, by 6% in the HBT group, and by 1% in the control group during the outpatient cardiac rehabilitation program. ET significantly increased in all study groups according to the analysis of exercise tolerance by the CET 4 months after CABG. However, the improvement was more pronounced in patients with SCT compared to other groups. One year after CABG, this difference balanced between the study groups. DP, assessed by the CET, significantly increased in patients undergoing SCT (p = 0.01), compared to other groups. There were no significant differences found in the rate of cardiovascular events between the study groups.Conclusion: Home-based trainings are inferior to SCT in the outpatient settings, but they are safe and may improve significantly the 6MWT values compared to patients in the control group. Therefore, home-based trainings may be recommended to patients, if they cannot visit the rehabilitation center.Цель. Оценить влияние трехмесячного курса контролируемых и домашних физических тренировок (ФТ) амбулаторного этапа реабилитации на толерантность к физической нагрузке, показатель «двойного произведения» у пациентов, подвергшихся операции коронарного шунтирования (КШ). Материалы и методы. Обследовано 114 мужчин трудоспособного возраста с ишемической болезнью сердца (ИБС), перенесших КШ. Пациенты были разделены на три группы: группа пациентов с контролируемыми велотренировками (ВТ) (n=36), группа пациентов с домашними тренировками ДТ (n=36) и группа сравнения, наблюдающаяся в поликлинике по месту жительства, без ФТ (n=42). Оценивали показатели теста шестиминутной ходьбы (ТШХ), толерантность к физической нагрузке (ТФН) и двойное произведение (ДП) по результатам велоэргометрии (ВЭМ) до операции, через 1 месяц, 4 месяца и через год после КШ. Результаты. За время тренировок показатели ТШХ возросли в группе ВТ на 9%, в группе ДТ – на 6%, в группе без ФТ – на 1%. При анализе переносимости физической нагрузки по данным ВЭМ, через 4 месяца после КШ ТФН достоверно увеличилась во всех сравниваемых группах, но более выраженно это увеличение отмечалось у пациентов с ВТ в сравнении с двумя другими группами. Однако через год после КШ это преимущество утрачивалось. ДП, оцененное при ВЭМ, на фоне тренировок достоверно увеличилось только у пациентов в группе с ВТ (р=0,01). В двух других группах достоверного прироста данного показателя не отмечалось. По количеству развития сердечно-сосудистых событий сравниваемые группы не различались. Заключение. Домашние физические тренировки уступают в эффективности ВТ в условиях лечебного учреждения, однако безопасны и значимо улучшают показатели ТФН в сравнении с пациентами без ФТ, а потому могут быть рекомендованы пациентам при невозможности посещения ими реабилитационного центра

The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination

RAD51 recombinase polymerizes at the site of double-strand breaks (DSBs) where it performs DSB repair. The loss of RAD51 causes extensive chromosomal breaks, leading to apoptosis. The polymerization of RAD51 is regulated by a number of RAD51 mediators, such as BRCA1, BRCA2, RAD52, SFR1, SWS1, and the five RAD51 paralogs, including XRCC3. We here show that brca2-null mutant cells were able to proliferate, indicating that RAD51 can perform DSB repair in the absence of BRCA2. We disrupted the BRCA1, RAD52, SFR1, SWS1, and XRCC3 genes in the brca2-null cells. All the resulting double-mutant cells displayed a phenotype that was very similar to that of the brca2-null cells. We suggest that BRCA2 might thus serve as a platform to recruit various RAD51 mediators at the appropriate position at the DNA–damage site

School in the Soviet Painting of the 1950s: Pictorial Representation of Ideological Strategie

The main issue the paper concerns is the theoretical and cultural interpretation of the 1940- 1950s social realist art depicting the Soviet school. The study advocates for a closer attention of cultural studies to the intertwining phenomena of Soviet mundanity and politically-charged painting. Hypothetically, the interconnection could be attributed to the transformation of the Soviet culture as a whole, with the pedagogical model of Soviet school as one key institutional elements. As Soviet art represented the state political project, each topic and body served some ideological needs. Thus, the paper aims at clarifying the cultural functions school art played. The analysis is dedicated to the post-WW2 canvases, to the period of the late 1940s‒1950s in particular due to the basic shifts in socialist realist painting both in terms of form and essence, which paralleled social and political transformations. The visual studies’ approach to artistic objects adopted by the authors serves as methodological contribution to cultural studies closely connected to political history, as it highlights the ideological sources of Soviet school painting and implicit pedagogical strategies designed to implement the Soviet social policy. The article provides the examples of the most significant paintings concerning the issue. The study has revealed that the era of school art combined a significant feature of early Soviet art – monumental pathos (however, deprived of motifs connected with the Great patriotic war and the 1917 revolution) – with micro-level mundane topics, mostly labour episodes. What is particular about school as such a topic is the role this institution played in the Soviet anthropologic project. As early stages of education are proved to be the most efficient in accelerating a new type of a socialist person, a future Soviet worker, the school realm was the base of value and practices indoctrination. The state policy translated the societal needs and purposes into the art. Having examined the key ideological concepts of the Soviet culture being inherent in Soviet school painting, certain functions were discovered. School is firstly depicted just as a background of state apotheosis. Secondly, it is perceived as a sacral locus where one becomes a Soviet person is both rituals and practices. Thirdly, school art is used to explain the novel principles of constructing a new person – personal approaches combined with growing group responsibility. And, finally, all that contributes to depicting the character traits which pupils was supposed to develop at school

The relationship between adherence to therapy and the style of communicative interaction of the attending physician and patients undergoing coronary artery bypass graft

Aim. To study the communicative characteristics of the attending physician, assessed by the patient, and analyze their connection with adherence to the treatment of patients with coronary artery disease (CAD) undergoing coronary artery bypass graft (CABG).Material and methods. The study included 366 patients — men aged 41 to 77 years old (mean age 59,9±6,9 years) with a stable form of CAD. The patients included in the study were examined 5­7 days before the CABG and 6 months after it. The clinical condition of the patient, the presence of cardiovascular risk factors and the therapy taken before and within 6 months after were assessed. Before being discharged from the clinic, A. А. Leontiev communication card was used to determine the model of communicative interaction.Results. The higher the patient assessed the communicative competence of the doctor according to the several parameters (“benevolence”, “encouragement of initiative”, “openness”, “activity” and “flexibility”), the higher his adherence to treatment was. Patients who gave a low rating to the attending physician by the communicative parameters (“openness”, “flexibility” and “interest” in communication), had the lowest adherence to treatment.Conclusion. The adherence to treatment of CAD patients is influenced by such communicative characteristics of the attending physician as “benevolence”, “encouragement of initiative”, “openness”, “activity” and “flexibility” qualify as democratic style of communication between a doctor and a patient

THE RELATIONSHIP BETWEEN PSYCHOLOGICAL CHARACTERISTICS OF THE ATTITUDE TO THE DISEASE, COPING BEHAVIOR OF PATIENTS WITH ISCHEMIC HEART DISEASE, AND THEIR COGNITIVE STATUS

The paper presents the study of the relationship between the attitude to the disease, coping behavior of patients with coronary heart disease prior to coronary bypass grafting (CABG), and indicators of cognitive status. Bekhterev Institute Personality Questionnaire, Ways of Coping Behavior test by R. Lazarus, Mini-Mental State Examination scale, Frontal Dysfunction Battery test, and Clock- Drawing test were used in the study. The sample included 132 patients. The results of study show that in patients with coronary artery disease prior to CABG the most frequently observed type of attitude to the disease is either the harmonious type or a combination of harmonious and ergopathic types. Confrontation, Distancing, and Problem Solution Planning were identified as the preferred coping strategies. Correlation analysis revealed positive associations between cognitive status and harmonious, ergopathic, and hypochondriac types of attitude to the disease, and negative associations between cognitive status and anosognostic and sensitive types of attitude to the disease. Furthermore, positive correlations between cognitive status and Confrontation, Self-control, Responsibility taking, Problem Solution Planning, Positive revaluation coping strategies and negative correlations between cognitive status and Distancing and Escape-avoidance coping strategies were found. The results of this study will help to improve the level of diagnostic and rehabilitation psychological care of patients with coronary artery disease in preparation for CABG

Nucleotide cofactor-dependent structural change of Xenopus laevis Rad51 protein filament detected by small-angle neutron scattering measurements in solution

Rad51 protein, a eukaryotic homologue of RecA protein, forms a filamentous complex with DNA and catalyzes homologous recombination. We have analyzed the structure of Xenopus Rad51 protein (XRad51.1) in solution by small-angle neutron scattering (SANS). The measurements showed that XRad51.1 forms a helical filament independently of DNA. The sizes of the cross-sectional and helical pitch of the filament could be determined, respectively, from a Guinier plot and the position of the subsidiary maximum of SANS data. We observed that the helical structure is modified by nucleotide binding as in the case of RecA. Upon ATP binding under high-salt conditions (600 mM NaCl), the helical pitch of XRad51.1 filament was increased from 8 to 10 nm and the cross-sectional diameter decreased from 7 to 6 nm. The pitch sizes of XRad51.1 are similar to, though slightly larger than, those of RecA filament under corresponding conditions. A similar helical pitch size was observed by electron microscopy for budding yeast Rad51 [Ogawa, T., et al. (1993) Science 259, 1896-1899]. In contrast to the RecA filament, the structure of XRad51.1 filament with ADP is not significantly different from that with ATP. Thus, the hydrolysis of ATP to ADP does not modify the helical filament of XRad51.1. Together with our recent observation that ADP does not weaken the XRad51.1/DNA interaction, the effect of ATP hydrolysis on XRad51.1 nucleofilament should be very different from that on RecA