24 research outputs found

    On cosmic rotation

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    We overview our recent studies of cosmological models with expansion and global rotation. Problems of the early rotating models are discussed, and the class of new viable cosmologies is described in detail. Particular attention is paid to the observational effects of the cosmic rotation.Comment: 22 pages, Revte

    Spacetime Splitting, Admissible Coordinates and Causality

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    To confront relativity theory with observation, it is necessary to split spacetime into its temporal and spatial components. The (1+3) timelike threading approach involves restrictions on the gravitational potentials (gμν)(g_{\mu \nu}), while the (3+1) spacelike slicing approach involves restrictions on (gμν)(g^{\mu \nu}). These latter coordinate conditions protect chronology within any such coordinate patch. While the threading coordinate conditions can be naturally integrated into the structure of Lorentzian geometry and constitute the standard coordinate conditions in general relativity, this circumstance does not extend to the slicing coordinate conditions. We explore the influence of chronology violation on wave motion. In particular, we consider the propagation of radiation parallel to the rotation axis of stationary G\"odel-type universes characterized by parameters η>0\eta > 0 and λ>0\lambda > 0 such that for η1\eta 1) chronology is protected (violated). We show that in the WKB approximation such waves can freely propagate only when chronology is protected.Comment: 25 pages, 3 figures; v2: minor typos corrected, accepted for publication in Phys. Rev.

    Vorticity production and survival in viscous and magnetized cosmologies

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    We study the role of viscosity and the effects of a magnetic field on a rotating, self-gravitating fluid, using Newtonian theory and adopting the ideal magnetohydrodynamic approximation. Our results confirm that viscosity can generate vorticity in inhomogeneous environments, while the magnetic tension can produce vorticity even in the absence of fluid pressure and density gradients. Linearizing our equations around an Einstein-de Sitter cosmology, we find that viscosity adds to the diluting effect of the universal expansion. Typically, however, the dissipative viscous effects are confined to relatively small scales. We also identify the characteristic length bellow which the viscous dissipation is strong and beyond which viscosity is essentially negligible. In contrast, magnetism seems to favor cosmic rotation. The magnetic presence is found to slow down the standard decay-rate of linear vortices, thus leading to universes with more residual rotation than generally anticipated.Comment: Minor changes. References added and updated. Published versio

    A point mutation in cpsE renders Streptococcus pneumoniae nonencapsulated and enhances its growth, adherence and competence.

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    BACKGROUND: The polysaccharide capsule is a major virulence factor of the important human pathogen Streptococcus pneumoniae. However, S. pneumoniae strains lacking capsule do occur. RESULTS: Here, we report a nasopharyngeal isolate of Streptococcus pneumoniae composed of a mixture of two phenotypes; one encapsulated (serotype 18C) and the other nonencapsulated, determined by serotyping, electron microscopy and fluorescence isothiocyanate dextran exclusion assay.By whole genome sequencing, we demonstrated that the phenotypes differ by a single nucleotide base pair in capsular gene cpsE (C to G change at gene position 1135) predicted to result in amino acid change from arginine to glycine at position 379, located in the cytoplasmic, enzymatically active, region of this transmembrane protein. This SNP is responsible for loss of capsule production as the phenotype is transferred with the capsule operon. The nonencapsulated variant is superior in growth in vitro and is also 117-fold more adherent to and more invasive into Detroit 562 human epithelial cells than the encapsulated variant.Expression of six competence pathway genes and one competence-associated gene was 11 to 34-fold higher in the nonencapsulated variant than the encapsulated and transformation frequency was 3.7-fold greater. CONCLUSIONS: We identified a new single point mutation in capsule gene cpsE of a clinical S. pneumoniae serotype 18C isolate sufficient to cause loss of capsule expression resulting in the co-existence of the encapsulated and nonencapsulated phenotype. The mutation caused phenotypic changes in growth, adherence to epithelial cells and transformability. Mutation in capsule gene cpsE may be a way for S. pneumoniae to lose its capsule and increase its colonization potential

    Cutaneous wound healing: recruiting developmental pathways for regeneration

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