853 research outputs found
Thioamides. XI. The Preparation of 5-Bromo-2-thiofuramides
A number of 5-bromo-2-furamides, obtained from 5-bromo-
2-furoyl chloride and ammonia or various amines, have been
converted to corresponding thioamides by thiation with phosphorus
pentasulfide in dry dioxane
Thioamides. XI. The Preparation of 5-Bromo-2-thiofuramides
A number of 5-bromo-2-furamides, obtained from 5-bromo-
2-furoyl chloride and ammonia or various amines, have been
converted to corresponding thioamides by thiation with phosphorus
pentasulfide in dry dioxane
Molecular diagnostic and genetic characterization of highly pathogenic viruses: application during Crimean–Congo haemorrhagic fever virus outbreaks in Eastern Europe and the Middle East
AbstractSeveral haemorrhagic fevers are caused by highly pathogenic viruses that must be handled in Biosafety level 4 (BSL–4) containment. These zoonotic infections have an important impact on public health and the development of a rapid and differential diagnosis in case of outbreak in risk areas represents a critical priority. We have demonstrated the potential of a DNA resequencing microarray (PathogenID v2.0) for this purpose. The microarray was first validated in vitro using supernatants of cells infected with prototype strains from five different families of BSL-4 viruses (e.g. families Arenaviridae, Bunyaviridae, Filoviridae, Flaviviridae and Paramyxoviridae). RNA was amplified based on isothermal amplification by Phi29 polymerase before hybridization. We were able to detect and characterize Nipah virus and Crimean–Congo haemorrhagic fever virus (CCHFV) in the brains of experimentally infected animals. CCHFV was finally used as a paradigm for epidemics because of recent outbreaks in Turkey, Kosovo and Iran. Viral variants present in human sera were characterized by BLASTN analysis. Sensitivity was estimated to be 105–106 PFU/mL of hybridized cDNA. Detection specificity was limited to viral sequences having ˜13–14% of global divergence with the tiled sequence, or stretches of ˜20 identical nucleotides. These results highlight the benefits of using the PathogenID v2.0 resequencing microarray to characterize geographical variants in the follow-up of haemorrhagic fever epidemics; to manage patients and protect communities; and in cases of bioterrorism
The UTfit Collaboration Average of D meson mixing data: Spring 2012
We derive constraints on the parameters , and
that describe meson mixing using all available data, allowing
for CP violation. We also provide posterior distributions and predictions for
observable parameters appearing in physics.Comment: 5 pages, 3 figure
Observation of and search for violation in radiative charm decays
We report the first observation of the radiative charm decay and the first search for violation in decays , , and , using a data sample of
943 fb collected with the Belle detector at the KEKB asymmetric-energy
collider. The branching fraction is measured to be , where the first
uncertainty is statistical and the second is systematic. The obtained
asymmetries, , , and
, are consistent with no violation. We also present an improved
measurement of the branching fractions and
Evidence for B- -> Ds+ K- l- nubar and search for B- -> Ds*+ K- l- nubar
We report measurements of the decays B- -> Ds(*)+ K- l- nubar in a data
sample containing 657x10^6 BBbar pairs collected with the Belle detector at the
KEKB asymmetric-energy e+e- collider. We observe a signal with a significance
of 6 sigma for the combined Ds and Ds* modes and find the first evidence of the
B- -> Ds+ K- l- nubar decay with a significance of 3.4 sigma. We measure the
following branching fractions: BF(B- -> Ds+ K- l nubar) = (0.30 +/- 0.09(stat)
+0.11 -0.08(syst)) x 10^-3 and BF(B- -> Ds*+ K- l- nubar) = (0.59 +/-
0.12(stat) +/- 0.15(syst)) x 10^-3 and set an upper limit BF(B- -> Ds*+ K- l-
nubar) < 0.56 x 10^-3 at the 90% confidence level. We also present the first
measurement of the Ds+K- invariant mass distribution in these decays, which is
dominated by a prominent peak around 2.6 GeV/c^2.Comment: Submitted to Phys. Rev.
Observation of Mixing in Collisions
We observe mixing in the decay
using a data sample of integrated luminosity 976 fb collected with the
Belle detector at the KEKB asymmetric-energy collider. We measure the
mixing parameters and and the ratio of doubly Cabibbo-suppressed to
Cabibbo-favored decay rates , where the
uncertainties are statistical and systematic combined. Our measurement excludes
the no-mixing hypothesis at the 5.1 standard deviation level.Comment: 6 pages, 4 figure
Energy scan of the cross sections and evidence for decays into charged bottomonium-like states
Using data collected with the Belle detector at the KEKB asymmetric-energy
collider, we measure the energy dependence of the cross sections from thresholds up to GeV.
We find clear and peaks with little or no
continuum contribution. We study the resonant substructure of the
transitions and find evidence that they
proceed entirely via the intermediate isovector states and
. The relative fraction of these states is loosely constrained by
the current data: the hypothesis that only is produced is excluded
at the level of 3.3 standard deviations, while the hypothesis that only
is produced is not excluded at a significant level.Comment: 8 pages, 4 figures, submitted to Physical Review Letter
Arthroscopic removal of an osteoid osteoma of the acetabulum
In this case report, we describe the arthroscopic removal of an osteoid osteoma from the acetabulum in a young adolescent. After identifying the osteoid osteoma close to the cartilage with MRI and CT investigations, we decided that in this case, arthroscopic removal was the best treatment. In the case of an osteoid osteoma in the acetabulum close to the cartilage, arthroscopic removal should be considered as one can treat the associated osteochondritic lesion during this procedure
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