Time-extended inductive tokamak discharges with differentially-tilted toroidal field coils

The strong toroidal magnetic field required for plasma confinement in tokamaks is generated by a set of D-shaped coils lying equidistant on meridian planes toroidally located around the central axis of the device. A major technological challenge tied to this configuration is represented by the large Lorentz force acting on the coils and arising from the interaction of the coils’ currents with the magnetic field generated by the coil system itself. As this force is given by the cross product of the coil current and the magnetic field, various kinds of coil geometry modification have been proposed to alleviate this problem, from an inclination of the entire coil in order to maintain its planarity, to azimuthal tilting of all, or parts of, the coil profile. When the inner legs of the coils are tilted, apart from a reduction of the electromagnetic forces, a solenoid-like structure is formed which introduces additional magnetic flux linked to the plasma. Considering compact, high field devices, it is shown that when this additional flux is exploited, totally or in part, to ramp up the plasma current, the discharge time can be extended by a significant amount without resorting to noninductive current drive systems. Operational scenarios with inner-leg-tilted toroidal field coils are presented

Neon seeding effects on two high-performance baseline plasmas on the Joint European Torus

We present the JETTO-QuaLiKiz-SANCO fully predictive modelling of two JET-ILW high-performance baseline plasmas, a Ne seeded shot and an equivalent unseeded one. The motivation of the work lies in the experimental observation of a slightly higher confinement and performance of the Ne seeded shot with respect to the unseeded one, despite sharing the same main plasma parameters and heating powers. Moreover, the neon seeded shot shows a lower pedestal electron density and a higher core ion temperature with respect to the unseeded one. Integrated modelling is performed in order to understand if the cause of the improved confinement has to be ascribed to the improved pedestal parameters with neon seeding or if an impurity-induced turbulence stabilization is at play. The QuaLiKiz transport model is used for predicting the electron density, electron and ion temperatures and rotation in the core up to the pedestal top, while the pedestal is empirically modelled to reproduce the experimental kinetic profiles. The thermal diffusivities of the two shots, computed by QuaLiKiz, are compared, as well as the turbulence spectra, suggesting that the reduced transport found in the neon seeded shot is due in part to the stabilization of ion temperature gradient and electron temperature gradient modes. Further modelling is performed in order to disentangle the neon seeding effects, which are a direct effect on the turbulence stabilization and an indirect effect on the pedestal parameters. The results suggest that the improved performance with neon is due to a combination of turbulence stabilization and improved pedestal parameters

Case Report Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease

The time for starting a patient with Fabry disease on enzyme replacement therapy is still a matter of debate, particularly when no overt classical clinical signs or symptoms are present. With respect to Fabry nephropathy, a dual problem coexists: the reluctance of many nephrologists to start enzyme replacement infusion until signs of renal disease appear as the appearance of proteinuria or an elevation in serum creatinine and the lack of validated biomarkers of early renal damage. In this regard, proteinuria is nowadays considered as an early and appropriate marker of kidney disease and of cardiovascular morbidity and mortality. However, in this report we demonstrate that podocyturia antedates the classical appearance of proteinuria and could be considered as an even earlier biomarker of kidney damage. Podocyturia may be a novel indication for the initiation of therapy in Fabry disease

Modelling performed for predictions of fusion power in JET DTE2: overview and lessons learnt

For more than a decade, an unprecedented predict-first activity has been carried in order to predict the fusion power and provide guidance to the second Deuterium–Tritium (D–T) campaign performed at JET in 2021 (DTE2). Such an activity has provided a framework for a broad model validation and development towards the D–T operation. It is shown that it is necessary to go beyond projections using scaling laws in order to obtain detailed physics based predictions. Furthermore, mixing different modelling complexity and promoting an extended interplay between modelling and experiment are essential towards reliable predictions of D–T plasmas. The fusion power obtained in this predict-first activity is in broad agreement with the one finally measured in DTE2. Implications for the prediction of fusion power in future devices, such as ITER, are discussed

The Effect of Anandamide on Uterine Nitric Oxide Synthase Activity Depends on the Presence of the Blastocyst

Nitric oxide production, catalyzed by nitric oxide synthase (NOS), should be strictly regulated to allow embryo implantation. Thus, our first aim was to study NOS activity during peri-implantation in the rat uterus. Day 6 inter-implantation sites showed lower NOS activity (0.19±0.01 pmoles L-citrulline mg prot−1 h−1) compared to days 4 (0.34±0.03) and 5 (0.35±0.02) of pregnancy and to day 6 implantation sites (0.33±0.01). This regulation was not observed in pseudopregnancy. Both dormant and active blastocysts maintained NOS activity at similar levels. Anandamide (AEA), an endocannabinoid, binds to cannabinoid receptors type 1 (CB1) and type 2 (CB2), and high concentrations are toxic for implantation and embryo development. Previously, we observed that AEA synthesis presents an inverted pattern compared to NOS activity described here. We adopted a pharmacological approach using AEA, URB-597 (a selective inhibitor of fatty acid amide hydrolase, the enzyme that degrades AEA) and receptor selective antagonists to investigate the effect of AEA on uterine NOS activity in vitro in rat models of implantation. While AEA (0.70±0.02 vs 0.40±0.04) and URB-597 (1.08±0.09 vs 0.83±0.06) inhibited NOS activity in the absence of a blastocyst (pseudopregnancy) through CB2 receptors, AEA did not modulate NOS on day 5 pregnant uterus. Once implantation begins, URB-597 decreased NOS activity on day 6 implantation sites via CB1 receptors (0.25±0.04 vs 0.40±0.05). While a CB1 antagonist augmented NOS activity on day 6 inter-implantation sites (0.17±0.02 vs 0.27±0.02), a CB2 antagonist decreased it (0.17±0.02 vs 0.12±0.01). Finally, we described the expression and localization of cannabinoid receptors during implantation. In conclusion, AEA levels close to and at implantation sites seems to modulate NOS activity and thus nitric oxide production, fundamental for implantation, via cannabinoid receptors. This modulation depends on the presence of the blastocyst. These data establish cannabinoid receptors as an interesting target for the treatment of implantation deficiencies

Overview of the FTU results

Since the 2018 IAEA FEC Conference, FTU operations have been devoted to several experiments covering a large range of topics, from the investigation of the behaviour of a liquid tin limiter to the runaway electrons mitigation and control and to the stabilization of tearing modes by electron cyclotron heating and by pellet injection. Other experiments have involved the spectroscopy of heavy metal ions, the electron density peaking in helium doped plasmas, the electron cyclotron assisted start-up and the electron temperature measurements in high temperature plasmas. The effectiveness of the laser induced breakdown spectroscopy system has been demonstrated and the new capabilities of the runaway electron imaging spectrometry system for in-flight runaways studies have been explored. Finally, a high resolution saddle coil array for MHD analysis and UV and SXR diamond detectors have been successfully tested on different plasma scenarios

Spectroscopic camera analysis of the roles of molecularly assisted reaction chains during detachment in JET L-mode plasmas

The roles of the molecularly assisted ionization (MAI), recombination (MAR) and dissociation (MAD) reaction chains with respect to the purely atomic ionization and recombination processes were studied experimentally during detachment in low-confinement mode (L-mode) plasmas in JET with the help of experimentally inferred divertor plasma and neutral conditions, extracted previously from filtered camera observations of deuterium Balmer emission, and the reaction coefficients provided by the ADAS, AMJUEL and H2VIBR atomic and molecular databases. The direct contribution of MAI and MAR in the outer divertor particle balance was found to be inferior to the electron-atom ionization (EAI) and electron-ion recombination (EIR). Near the outer strike point, a strong atom source due to the D+2-driven MAD was, however, observed to correlate with the onset of detachment at outer strike point temperatures of Te,osp = 0.9-2.0 eV via increased plasma-neutral interactions before the increasing dominance of EIR at Te,osp < 0.9 eV, followed by increasing degree of detachment. The analysis was supported by predictions from EDGE2D-EIRENE simulations which were in qualitative agreement with the experimental observations

Shattered pellet injection experiments at JET in support of the ITER disruption mitigation system design

A series of experiments have been executed at JET to assess the efficacy of the newly installed shattered pellet injection (SPI) system in mitigating the effects of disruptions. Issues, important for the ITER disruption mitigation system, such as thermal load mitigation, avoidance of runaway electron (RE) formation, radiation asymmetries during thermal quench mitigation, electromagnetic load control and RE energy dissipation have been addressed over a large parameter range. The efficiency of the mitigation has been examined for the various SPI injection strategies. The paper summarises the results from these JET SPI experiments and discusses their implications for the ITER disruption mitigation scheme