Separate Aspects of Administrative and Legal Regulation of Activity of Passenger Taxis

The article discusses the features of the legal regulation of the activities for the transport of passengers and baggage by taxi in the Russian Federation in the context of ensuring road safety. The Author analyzes the specifics of participation in traffic of vehicles intended for the carriage of passengers as a passenger taxi. Attention is drawn to the formality of existing requirements for drivers applying for a permit to carry out the specified type of activity, and the need for their adjustment is justified. Suggestions are being made aimed at improving legislation in the field of taxi transportation. Separate collisions are investigated that arise in the law enforcement practice of the traffic police when exercising control and supervisory powers over the observance of road safety requirements by passenger taxis, and suggested ways to resolve them

High frequency polarization switching of a thin ferroelectric film

We consider both experimentally and analytically the transient oscillatory process that arises when a rapid change in voltage is applied to a $Ba_xSr_{1-x}TiO_3$ ferroelectric thin film deposited on an $Mg0$ substrate. High frequency ($\approx 10^{8} rad/s$) polarization oscillations are observed in the ferroelectric sample. These can be understood using a simple field-polarization model. In particular we obtain analytic expressions for the oscillation frequency and the decay time of the polarization fluctuation in terms of the material parameters. These estimations agree well with the experimental results

О ВОЗМОЖНОСТИ МЕЖДИСЦИПЛИНАРНОЙ ИНТЕГРАЦИИ РУССКОГО ЯЗЫКА И ХИМИИ В СТАРШИХ КЛАССАХ ОБЩЕОБРАЗОВАТЕЛЬНОЙ ШКОЛЫ

A study in the field of interdisciplinary interference of the Russian language and chemistry in high school.Проведено исследование в области междисциплинарной интеграции русского языка и химии в старших классах общеобразовательной школы

АНАЛИЗ И ДИАГНОСТИКА УРОВНЕЙ УЧЕБНО-ИНФОРМАЦИОННЫХ УМЕНИЙ СТУДЕНТОВ 1-ОГО КУРСА ЕСТЕСТВЕННО-НАУЧНОГО ФАКУЛЬТЕТА 2018–2019 ГОДА

This article diagnoses and analyzes the educational and information skills of first-year students. В данной статье диагностируются и анализируются учебно-информационные умения студентов первого курса.

EXPRESSION OF TLR2, TLR3, TLR4 AND PROINFLAMMATORY TNF AND IL-6 CYTOKINES IN LIVER BIOPSIES OF NONALCOHOLIC FATTY LIVER DISEASE PATIENTS

Non-alcoholic fatty liver disease (NAFLD) is a group of conditions closely associated with obesity that are among the most common and socially significant liver diseases in the modern Western world. The emergence and progression of NAFLD from simple steatosis to non-alcoholic steatohepatitis with the subsequent development of fibrosis are the leading factors in the pathogenesis of a significant proportion of the most severe liver pathologies, such as cirrhosis and hepatocellular carcinoma, as well as extrahepatic metabolic complications of NAFLD, such as insulin resistance and type 2 diabetes mellitus. The inflammatory component is one of the most important factors in the pathogenesis of NAFLD, particularly in the context of the progression of simple steatosis to non-alcoholic steatohepatitis. At the same time, the role of the most important mediators of the inflammatory response, innate immunity receptors and the Toll-like receptors in particular, in the pathogenesis of NAFLD has been poorly studied. In the present work, we first used the bioinformatics analysis of the publicly available gene expression databases to demonstrate that only TLR1, TLR2, TLR3 and TLR4 were significantly expressed in the healthy human liver. We then used the reverse transcription PCR to measure the mRNA expression levels of TLR2, TLR3, and TLR4, as well as those of the important pro-inflammatory mediators tumor necrosis factor (TNF) and interleukin-6 (IL-6), in the liver biopsy specimens obtained from 20 patients with NAFLD (simple steatosis, n = 10; non-alcoholic steatohepatitis, n = 10), as well as from 4 obese patients with clinical suspicion for NAFLD but no histological signs of NAFLD in their liver biopsies. We found a significant increase in the expression of TLR2, TLR3 and TLR4 mRNA in liver biopsy samples obtained from patients with non-alcoholic steatohepatitis as compared to those obtained from controls without histological signs of NAFLD. We were also able to demonstrate the association between the hepatic levels of TLR2, TLR3 and TLR4 mRNAs with the histological degree of liver damage as evidenced by the degree of steatosis and balloon dystrophy of hepatocytes, as well as with the plasma levels of uric acid, the important endogenous stimulator of innate immunity. Our data indicate the possible involvement of innate immunity, particularly the Toll-like receptors, in the pathogenesis of NAFLD

Туберкулез и микобактериоз легких у больных на поздних стадиях ВИЧ-инфекции

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ОЦЕНКА ВАЛЕОЛОГИЧЕСКИХ ЗНАНИЙ И ВАЛЕОЛОГИЧЕСКОЙ КУЛЬТУРЫ У ОБУЧАЮЩИХСЯ В СТАРШИХ КЛАССАХ НА УРОКАХ ХИМИИ

The article presents the results obtained in the study of valeological knowledge and valeological culture of teaching older classes of secondary school.В статье представлены результаты полученные в ходе исследования валеологических знаний и валеологической культуры обучающихся старших классов общеобразовательной школы

DIAGNOSTICS, CLINICAL COURSE AND EFFECTIVENESS OF TREATMENT OF NEWLY DIAGNOSED YOUNG PATIENTS WITH RESPIRATORY TUBERCULOSIS

We observed a group of 103 patients aged 18-30 years with pulmonary tuberculosis; each patient was observed for 12 months. 103 patients with pulmonary tuberculosis underwent a comprehensive clinical, radiological and microbiological examination. The carried out treatment was individualized basing on the presence and prevalence of cavities in the lungs, detection of Mycobacterium tuberculosis in sputum and determination of their drug sensitivity to anti-TB drugs. In 18.4 % of tuberculosis cases diagnosed with chest X-rays, intradermal Mantoux test with 2 TE PPD-L and Diaskintestom® was diagnostically irrelevant. 18.4 % of respiratory tuberculosis cases were detected during preventive chest X-ray and 81.6 % of patients were diagnosed in primary care facilities having referred with symptoms of inflammatory bronchopulmonary disease or concomitant diseases, combined with pulmonary involvement. We can conclude that without fluorography studies of the chest, intradermal Mantoux test with 2 TE PPD-L and Diaskintestom® is not a method for pulmonary tuberculosis timely diagnostics in people aged 18-30 years. The patients with pulmonary tuberculosis aged 18-30 years, diagnosed during preventive fluorography examination of the chest, after 12 months of treatment in 100 % managed to achieve clinical recovery. Same age patients with pulmonary tuberculosis, diagnosed when applying to primary care facilities with symptoms of inflammatory bronchopulmonary disease, after 12 months of treatment achieved clinical recovery only in 79.2 % and 20.8 % of them still had the lung cavities requiring further treatment and applying surgery to remove affected sections of the lungs

Multicomponent coating in purulent wound healing: A randomised controlled experimental study

Background. Purulent wound healing is a pressing surgical challenge relevant in 30−35% of patient cases. To the more, wound infectious agents elaborate resistance to available drugs warranting the development of new drug combinations exserting a multidirectional effect on the wound process.Objective. Using a purulent wound model to experimentally evaluate the efficiency of a new multicomponent wound coating comprised of polyethylene oxide and carboxymethylcellulose sodium-immobilised dioxidine, methyluracil, metronidazole and lidocaine hydrochloride in comparison with a legal approved wound coating drug preparation of beeswax and propolis-based dioxidine ointment.Methods. The antimicrobial activity range (disk-diffusion method) and local anaesthetic effect (Rainier’s method) of the developed wound coating have been assessed. The healing process was studied in a purulent wound model with 72 Wistar rats divided between two equal groups. The following methods were applied: visual wound inspection (wound cleansing time, absence of wound-surrounding tissue oedema, granulation and epithelisation), planimetric parameter estimation (wound area, healing rate, wound area reduction ratio), wound contamination and pH measurement, wound section cell morphometry (granulocyte, macrophage, lymphocyte and fibroblast counts, cell index estimation). Daily dressings were applied for 15 days.Results. The developed wound coating exhibited high efficiency against Gram-positive and Gram-negative bacteria in the zone of inhibition tests. Its local anaesthetic effect was significantly superior to the approved drug by the duration of action. The wound area reduction was 94.2 (93.7; 94.8)% in the experimental group and 86 (84.2; 88.8)% in the control (differences statistically significant) already on day 10. A maximal healing rate in both groups was registered in phase 1 of the wound process being 1.4 times higher in experiment compared to the control. The wound contamination was significantly lower in experiment vs. control on day 8 (p = 0.0075). Wound pH negatively correlated with the fibroblast count and positively — with the contamination level.Conclusion. The study demonstrates high efficiency of the developed wound coating against infectious agents and its positive healing impact via reducing phase 1 and stimulating proliferation in phase 2 of the wound process

ДИССЕМИНИРОВАННЫЙ И ГЕНЕРАЛИЗОВАННЫЙ ТУБЕРКУЛЕЗ ЛЕГКИХ И ОППОРТУНИСТИЧЕСКИЕ ЗАБОЛЕВАНИЯ У БОЛЬНЫХ НА ПОЗДНИХ СТАДИЯХ ВИЧ-ИНФЕКЦИИ С ИММУНОСУПРЕССИЕЙ

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