Residual Risk of Cardiovascular Complications in Case of Adequate Lipid-Lowering Therapy

This article is devoted to the problems of residual risk of cardiovascu1ar comp1ications deve1opment for high and very high risk patients under adequate lipid-fowering pharmacotherapy in spite of c^lestera! and tow-density 1ipoproteins target level achievement. Afong with classic risk factors the special atte^ton is given to 1ipoprotein (a) [LP (a)] as the most aggressive factor of cardwvascular system atherosclerotic diseases devetopment and their comp1ications. Great importance is attached to 1ipidopheresis

INNOVATIVE TECHNOLOGIES IN DIAGNOSIS AND TREATMENT OF EXTREME FAMILIAL HYPERCHOLESTEROLEMIA

The article reveals medical and social relevance of extreme familial hypercholesterolemia. It presents the main principles, innovative technologies and an algorithm of diagnosis, diagnostic verification, risk stratification of patients and optimization of the use of aggressive combined cholesterol-lowering drug treatment and precision of indications for plasma exchange and the lack of options

INNOVATIONS IN DIAGNOSTICS AND TREATMENT OF PATIENTS WITH HYPERTRIGLYCERIDEMIA

This article presents innovative techniques for diagnostics, risk stratification and treatment of patients with hypertriglyceridemia. Hypertriglyceridemia is not only known as an independent risk factor of cardiovascular diseases, but also its high level can become a cause of acute pancreatitis

INNOVATION TECHNOLOGY OF SUBCLINICAL ATHEROSCLEROSIS VERIFICATION

This review article presents duplex scanning of carotid arteries as a key and the most informative modern noninvasive innovation technology for diagnostics of subclinical atherosclerosis. It was noted that during primary prophylaxis the values of intima-media complex of these arteries allow performing risk stratification of patients and selection of high-risk patients for aggressive lipid-lowering pharmacotherapy

ENDOTHELIAL DYSFUNCTION AS PREDICTOR OF SUBCLINICAL AND MANIFEST ATHEROSCLEROSIS

This survey presents the role of endothelial dysfunction in pathogenesis of atherosclerotic cardiovascular diseases as predictor of their development. Leading risk factors of endothelial dysfunction and methods of its diagnostics are also shown. Special attention is given to non medicamental correction of endothelial function disorders and its pharmacotherapy with statins, inhibitors of angiotensin converting enzyme (ACE), calcium antagonists and other drugs