Actionable molecular biomarkers in primary brain tumors

Recent genome-wide studies of malignancies of the central nervous system (CNS) have revolutionized our understanding of the biology of these tumors. This newly gained knowledge provides a wealth of opportunity for biomarker-driven clinical research. To date, however, only few of the available molecular markers truly influence clinical decision-making and treatment. The most widely validated markers in neuro-oncology presently are: (i) MGMT promoter methylation as a prognostic and predictive marker in glioblastoma; (ii) codeletion of 1p and 19q differentiating oligodendrogliomas from astrocytomas; (iii) IDH1/2 mutations; and (iv) select pathway-associated mutations. This article focuses on currently impactful biomarkers in adult and pediatric brain cancers and it provides a perspective on the direction of research in this field

A robust approach to enhance tumor-selective accumulation of nanoparticles

10.18632/oncotarget.227Oncotarget24349759-6

European Project for Future Advances in Sciences and Technology for Nuclear Engineering Thermal-hydraulics (EUROFASTNET – 2001 activity)

A review of industrial needs for at least the next decade was performed and a list of 44 needs was established. The needs correspond to issues for which the industry has answers today but for which further R&D work is necessary for providing more accurate and/or more reliable answers. This list covers not only safety problems but also problems related to new reactor designs, reactor performance and availability, reactor ageing and extension of life. The State of the Art covered the physical and numerical modelling in present system codes and component codes and also some recent attempts to develop two-phase CFD type codes and advanced numerics. The available tools for uncertainty evaluation were also reviewed. Proposals for future R&D in 2-phase thermal-hydraulics were made, based on the review of the needs and on the State of the Art. They address the physical modelling, the numerics, the experiments and the uncertainty evaluation

Deliverable 1 of EUROFASTNET Project: Review of Industrial Needs

A review of industrial needs for at least the next decade was performed and a list of 44 needs was established. The needs correspond to issues for which the industry has answers today but for which further R&D work is necessary for providing more accurate and/or more reliable answers. This list covers not only safety problems but also problems related to new reactor designs, reactor performance and availability, reactor ageing and extension of life. The State of the Art covered the physical and numerical modelling in present system codes and component codes and also some recent attempts to develop two-phase CFD type codes and advanced numerics. The available tools for uncertainty evaluation were also reviewed. Proposals for future R&D in 2-phase thermal-hydraulics were made, based on the review of the needs and on the State of the Art. They address the physical modelling, the numerics, the experiments and the uncertainty evaluatio