Anomalous temperature dependence of surface tension and capillary waves at liquid gallium

The temperature dependence of surface tension \gamma(T) at liquid gallium is studied theoretically and experimentally using light scattering from capillary waves. The theoretical model based on the Gibbs thermodynamics relates the temperature derivative of \gamma to the surface excess entropy -\Delta S. Although capillary waves contribute to the surface entropy with a positive sign the effect of dipole layer on \Delta S is negative. Experimental data collected at a free Ga surface in the temperature range from 30 to 160 C show that the temperature derivative of the tension changes sign near 100 C.Comment: 11 pages, 1 Postscript figure, submitted to J. Phys.

Dynamics of viscous amphiphilic films supported by elastic solid substrates

The dynamics of amphiphilic films deposited on a solid surface is analyzed for the case when shear oscillations of the solid surface are excited. The two cases of surface- and bulk shear waves are studied with film exposed to gas or to a liquid. By solving the corresponding dispersion equation and the wave equation while maintaining the energy balance we are able to connect the surface density and the shear viscocity of a fluid amphiphilic overlayer with experimentally accessible damping coefficients, phase velocity, dissipation factor and resonant frequency shifts of shear waves.Comment: 19 pages, latex, 3 figures in eps-forma

Topology of six degrees of freedom magnetic bearing

A novel magnetic topology has been designed for a six degrees of freedom, magnetically levitated and driven mirror, to be used in a three dimensional (3D) measurement system based on laser interferometry. The translations of the mirror are to be kept small, whereas the rotations are to be controlled over a large range with a high bandwidth and high accuracy. Finite element modelling (FEM) is used to analyze the proposed topology. For computational load reduction, a 2D FEM model has been derived from the actual 3D topology, which incorporates most of the magnetic subsystems. Simulations show that cross-influence between the actuators is small, that the forces and torques are proportional to the applied currents and that the angle of the rotor is of little influence. This allows the multiple in multiple out system to be regarded as multiple linear single in single out systems. ©2000 American Institute of Physics

Probing liquid surface waves, liquid properties and liquid films with light diffraction

Surface waves on liquids act as a dynamical phase grating for incident light. In this article, we revisit the classical method of probing such waves (wavelengths of the order of mm) as well as inherent properties of liquids and liquid films on liquids, using optical diffraction. A combination of simulation and experiment is proposed to trace out the surface wave profiles in various situations (\emph{eg.} for one or more vertical, slightly immersed, electrically driven exciters). Subsequently, the surface tension and the spatial damping coefficient (related to viscosity) of a variety of liquids are measured carefully in order to gauge the efficiency of measuring liquid properties using this optical probe. The final set of results deal with liquid films where dispersion relations, surface and interface modes, interfacial tension and related issues are investigated in some detail, both theoretically and experimentally. On the whole, our observations and analyses seem to support the claim that this simple, low--cost apparatus is capable of providing a wealth of information on liquids and liquid surface waves in a non--destructive way.Comment: 25 pages, 12 figures, to appear in Measurement Science and Technology (IOP

Scattering off an SO(10) cosmic string

The scattering of fermions from the abelian string arising during the phase transition $SO(10) \rightarrow SU(5) \times Z_2$ induced by the Higgs in the 126 representation is studied. Elastic cross-sections and baryon number violating cross-sections due to the coupling to gauge fields in the core of the string are computed by both a first quantised method and a perturbative second quantised method. The elastic cross-sections are found to be Aharonov-Bohm type. However, there is a marked asymmetry between the scattering cross-sections for left and right handed fields. The catalysis cross-sections are small, depending on the grand unified scale. If cosmic strings were observed our results could help tie down the underlying gauge group.Comment: 20 page

Scattering from Electroweak Strings

The scattering of a charged fermion from an electroweak string is studied. Owing to an amplification of the wave function at the core radius, the cross sections for helicity flip processes can be largely enhanced. For $0 <\sin^2 \theta_w < 1/2$ (where $\theta_w$ is the Weinberg angle), $\omega \sim k \sim m_e$ and $kR \ll 1$, we show that the helicity flip differential cross section for electrons is of the order $m_e^{-1}$ and is independent of angle. We compare our results with those obtained in calculations of rates for baryon number violating processes in the core of a cosmic string. In that case, while the enhancement is a general phenomenon, its actual magnitude is extremely sensitive to the fractional flux carried by the string core. Apart from showing the existence of a similar enhancement effect for non-topological strings, our results indicate that in some models the magnitude of enhancement can be rendered much less sensitive to the value of the parameters in the theories. Scattering of particles off semi-local strings and axion strings are also considered.Comment: Replaced with revised version "Tex with phyzzx, 18 pages, CALT-68-1921 Non-trivial changes made: discussion on axion strings corrected. Overlap with a recently revised version of hep-ph/9311202 note

A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells.

BACKGROUND: Aneuploidy is a feature of most cancer cells that is often accompanied by an elevated rate of chromosome mis-segregation termed chromosome instability (CIN). While CIN can act as a driver of cancer genome evolution and tumor progression, recent findings point to the existence of a threshold level beyond which CIN becomes a barrier to tumor growth and therefore can be exploited therapeutically. Drugs known to increase CIN beyond the therapeutic threshold are currently few in number, and the clinical promise of targeting the CIN phenotype warrants new screening efforts. However, none of the existing methods, including the in vitro micronuclei (MNi) assay, developed to quantify CIN, is entirely satisfactory. METHODS: We have developed a new assay for measuring CIN. This quantitative assay for chromosome mis-segregation is based on the use of a non-essential human artificial chromosome (HAC) carrying a constitutively expressed EGFP transgene. Thus, cells that inherit the HAC display green fluorescence, while cells lacking the HAC do not. This allows the measurement of HAC loss rate by routine flow cytometry. RESULTS: Using the HAC-based chromosome loss assay, we have analyzed several well-known anti-mitotic, spindle-targeting compounds, all of which have been reported to induce micronuclei formation and chromosome loss. For each drug, the rate of HAC loss was accurately measured by flow cytometry as a proportion of non-fluorescent cells in the cell population which was verified by FISH analysis. Based on our estimates, despite their similar cytotoxicity, the analyzed drugs affect the rates of HAC mis-segregation during mitotic divisions differently. The highest rate of HAC mis-segregation was observed for the microtubule-stabilizing drugs, taxol and peloruside A. CONCLUSION: Thus, this new and simple assay allows for a quick and efficient screen of hundreds of drugs to identify those affecting chromosome mis-segregation. It also allows ranking of compounds with the same or similar mechanism of action based on their effect on the rate of chromosome loss. The identification of new compounds that increase chromosome mis-segregation rates should expedite the development of new therapeutic strategies to target the CIN phenotype in cancer cells

Why are sustainable practices often elusive? The role of information flow in the management of networked human-environment interactions

Analyzing the spatial and temporal properties of information flow with a multi-century perspective could illuminate the sustainability of human resource-use strategies. This paper uses historical and archaeological datasets to assess how spatial, temporal, cognitive, and cultural limitations impact the generation and flow of information about ecosystems within past societies, and thus lead to tradeoffs in sustainable practices. While it is well understood that conflicting priorities can inhibit successful outcomes, case studies from Eastern Polynesia, the North Atlantic, and the American Southwest suggest that imperfect information can also be a major impediment to sustainability. We formally develop a conceptual model of Environmental Information Flow and Perception (EnIFPe) to examine the scale of information flow to a society and the quality of the information needed to promote sustainable coupled natural-human systems. In our case studies, we assess key aspects of information flow by focusing on food web relationships and nutrient flows in socio-ecological systems, as well as the life cycles, population dynamics, and seasonal rhythms of organisms, the patterns and timing of species’ migration, and the trajectories of human-induced environmental change. We argue that the spatial and temporal dimensions of human environments shape society's ability to wield information, while acknowledging that varied cultural factors also focus a society's ability to act on such information. Our analyses demonstrate the analytical importance of completed experiments from the past, and their utility for contemporary debates concerning managing imperfect information and addressing conflicting priorities in modern environmental management and resource use

Sphalerons, spectral flow, and anomalies

The topology of configuration space may be responsible in part for the existence of sphalerons. Here, sphalerons are defined to be static but unstable finite-energy solutions of the classical field equations. Another manifestation of the nontrivial topology of configuration space is the phenomenon of spectral flow for the eigenvalues of the Dirac Hamiltonian. The spectral flow, in turn, is related to the possible existence of anomalies. In this review, the interconnection of these topics is illustrated for three particular sphalerons of SU(2) Yang-Mills-Higgs theory.Comment: 35 pages with revtex4; invited paper for the August special issue of JMP on "Integrability, topological solitons and beyond

Virus shapes and buckling transitions in spherical shells

We show that the icosahedral packings of protein capsomeres proposed by Caspar and Klug for spherical viruses become unstable to faceting for sufficiently large virus size, in analogy with the buckling instability of disclinations in two-dimensional crystals. Our model, based on the nonlinear physics of thin elastic shells, produces excellent one parameter fits in real space to the full three-dimensional shape of large spherical viruses. The faceted shape depends only on the dimensionless Foppl-von Karman number \gamma=YR^2/\kappa, where Y is the two-dimensional Young's modulus of the protein shell, \kappa is its bending rigidity and R is the mean virus radius. The shape can be parameterized more quantitatively in terms of a spherical harmonic expansion. We also investigate elastic shell theory for extremely large \gamma, 10^3 < \gamma < 10^8, and find results applicable to icosahedral shapes of large vesicles studied with freeze fracture and electron microscopy.Comment: 11 pages, 12 figure