Dependence of the odd-odd nucleus ¹⁹⁶Au level density on the parameters in interacting boson-fermion-fermion model (IBFFM)

The odd-odd nuclei are characterized by a level density which is high already in the low-energy region. This case displays a full complexity of the interwoven shell-model and collective degrees of freedom and thus provides an interesting testing ground for the pattern of nuclear level density. The level density of the odd-odd nucleus ¹⁹⁶Au is investigated in the interacting boson-fermion-fermion model which accounts for collectivity and complex interaction between quasiparticle and collective modes. In the present work, the IBFFM pattern of total and parametric dependent level densities is investigated and compared to the pattern found in previous investigations in the framework of combinatorial, thermodynamic and spectral distribution approaches

Notch1 pathway in adrenocortical carcinomas:correlations with clinical outcome

Previous SNP array analyses have revealed genomic alterations of the Notch pathway as being the most frequent abnormality in adrenocortical tumors (ACTs). The aim of the present study was to evaluate the expression of components of Notch signaling in ACTs and to correlate them with clinical outcome. The mRNA expression ofJAG1,NOTCH1, and selected target genes of NOTCH1 (HES1,HES5, andHEY2) was evaluated in 80 fresh frozen samples (28 normal adrenal glands (NAGs), 24 adenomas (ACAs), and 28 carcinomas (ACCs)) by quantitative RT-PCR. Immunohistochemistry was performed in 221 tissues on paraffin slides (16 NAGs, 27 ACAs, and 178 ACCs) for JAG1, activated NOTCH1 (aNOTCH1), and HEY2. An independent ACC validation cohort (n=77) was then also investigated.HEY2mRNA expression was higher in ACCs than it was in ACAs (P&lt;0.05). The protein expression of all of the factors was high (H-score 2–3) in a larger proportion of ACCs as compared to ACAs and NAGs (JAG1 in 27, 15, and 10%; aNOTCH1 in 13, 8, and 0%; HEY2 in 66, 61, and 33% respectively, allP&lt;0.001). High JAG1 expression was associated with earlier tumor stages and lower numbers of metastases in ACCs (bothP=0.08) and favorably impacted overall and progression-free survival (PFS) (131 vs 30 months, hazard ratio (HR) 0.45, and 37 vs 9 months, HR 0.51, bothP&lt;0.005). This impact on overall survival (OS) was confirmed in the validation cohort. No such association was observed for aNOTCH1 or HEY2. In conclusion, different components of the Notch1 signaling pathway are overexpressed in ACCs, which suggests a role for the pathway in malignant transformation. However, JAG1 is overexpressed in a subgroup of ACCs with a better clinical outcome.</jats:p

Contextual Approach to Acculturative Stress Among Latina Immigrants in the U.S.

Based on Family Stress Management theory, we explored the contextual influence on acculturative stress and psychological distress. We included 639 Latinas from the National Latino Asian American Survey. We hypothesized that (a) impact of acculturative stress on psychological distress depends on specific contexts; (b) U.S. climate (i.e., perceived discrimination, happiness with U.S. move, years in the U.S.) impacts acculturative stress and psychological distress the most, and (c) contextual factors interact in impacting acculturative stress. Acculturative stress did not always lead to psychological distress. Perceived discrimination and difficulty visiting family abroad were positively associated with acculturative stress. Years in the U.S. and happiness with the U.S. move were negatively associated with acculturative stress. Years in the U.S. and perceived discrimination interacted in predicting acculturative stress. These results can aid formulation of effective interventions that target contexts likely to impact acculturative stress and psychological distress among Latinas

“Women here are like at the time of Enver [Hoxha] …”: socialist and post-socialist gendered mobility in Albanian society

No description supplie