5 research outputs found
The effect of folate on ischemia/reperfusion injury in a rat adnexal torsion model
Purpose The ischemia/reperfusion (I/R) injury of ovaries in adnexal torsion may have inadvertent consequences. Many agents have been studied in terms of their ability to prevent reperfusion damage to ovaries in suspected cases. In this study, folic acid, known to have antioxidative properties, was investigated to determine whether it played a role in the prevention of I/R damage in a rat ovarian torsion model.Methods In this experimental study, 40 female adult Wistar-Albino rats were randomly divided into fve groups as control, ischemia, I/R, Fol2 (2 mg/kg folic acid), and Fol4 (4 mg/kg folic acid). In the Fol2 and Fol4 groups, folic acid was intra peritonelly administered 30 min before reperfusion. Blood samples were obtained from the tails of each rat at the second hour of reperfusion.Results The total oxidant status (TOS), total antioxidant status, cystatin C and folic acid levels of the fve groups were investigated. Folic acid in 2 mg/kg dose could moderately increase the serum folic acid concentration (15.75–19.95 ng/ml, p0.05), although there was no statistical diference in TOS levels (p=0.07). Folic acid in 4 mg/kg dose, could signifcantly increase the serum folic acid concentration (15.75–37.65 ng/ml). However, it did not signifcantly reduce the level of cystatin C (0.18–0.19 µg/L, p>0.05), and did not improve oxidative stress injury (76.05–130.58, p>0.05).Conclusion Folic acid in 2 mg/kg dose might improve the ovarian I/R injury though this was not statistically signifcant. Further studies are required to reach a defnitive conclusion about the protective efect of folic acid in I/R injury
Is there an association between liver type fatty acid binding protein and severity of preeclampsia?
Objective The aim of this study was to estimate the level
of liver fatty acid binding protein (LFABP) in women with
preeclampsia.
Method A case–control study was conducted in 90
pregnant women who were divided into the following three
groups: normal pregnancy (n = 30), mild–moderate preeclampsia
(n = 30), and severe preeclampsia (n = 30).
Maternal blood samples were obtained during an antenatal
clinic visit in normal pregnant women, and at the time of
diagnosis in women with preeclampsia. Serum LFABP
levels were measured by the quantitative sandwich enzyme
immunoassay technique.
Results Serum LFABP level was significantly higher in
severe and mild–moderate preeclampsia groups than normal
pregnancy group (1,709.90 ± 94.82, 1,614.93 ±
118.22, and 1,532.36 ± 140.98 pg/ml, respectively;
p\0.001). In multivariate analysis, the severity of preeclampsia
was correlated with LFABP level [unadjusted
odds ratio (95 % confidence interval), 1.008 (1.003–1.012),
p\0.001 and LDH 1.063 (1.029–1.099), p\0.001].
Conclusion Maternal serum LFABP level appears to be
correlated with the severity of the preeclampsia and can be
used to confirm the diagnosis
Severe 25-OH vitamin D deficiency as a reason for adverse pregnancy outcomes
Objective: There is a growing concern about the unfavorable effects of vitamin D deficiency in general population, including pregnant women, worldwide. The aim of this study is to evaluate the effect of severe maternal serum 25-OH vitamin D levels on adverse pregnancy outcomes in first trimester. Material and methods: Serum samples of 86 pregnant women in first trimester were collected prospectively from May 2017 to June 2017. Serum 25-OH vitamin D levels were analyzed by enzyme immunoassay method. Patients were classified according to maternal serum 25-OH vitamin D levels as group 1 (n¼34) 10ng/ml. The two groups were compared in terms of adverse pregnancy outcomes. Results: The mean 25-OH vitamin D levels of the total 86 pregnant women were 13.83 (6–48) ng/ml. 40% of the pregnant women had low level of 25-OH vitamin D levels (<10ng/ml). The adverse pregnancy outcomes were significantly increased in group 1 (p<.018). Conclusions: Maternal serum 25-OH vitamin D levels <10ng/ml is a risk factor for adverse pregnancy outcomes. 25-OH vitamin D levels should be screened in high-risk pregnant women and treated in case of deficiency
The effects of water immersion and epidural analgesia on cellular immune response, neuroendocrine, and oxidative markers
Background/aim: Water immersion and epidural analgesia are the most preferred pain relief methods during the labor process. Adverse
effects related to these methods, impact on the labor, and perception of pain is well studied in the literature. We aimed to investigate the
cord blood level of copeptin, total serum oxidant (TOS), antioxidant (TAS), interleukin (IL)-1, IL-6, and oxytocin after the labor with
water immersion, epidural analgesia, and vaginal birth without pain relief.
Materials and methods: The study was conducted with 102 healthy pregnant women admitted to the obstetric delivery unit for
noncomplicated term birth. Copeptin, oxytocin, TAS, TOS, IL-1, and IL-6 levels of cord blood and obstetric and neonatal results after
vaginal birth were compared.
Results: The study included a total of 102 patients (group 1 = 30, group 2 = 30, and group 3 = 42). We found no significant difference
between the three groups in terms of BMI, age, gravidity, parity, birth week, birth weight, interventional birth, perineal trauma,
breastfeeding, duration of labor, oxytocin, IL-1 and IL-6 levels (p > 0.05). Neonatal intensive care unit (NICU) need, TAS, TOS, and
copeptin levels were higher. Apgar scores were lower in the epidural group (p = 0.011, p = 0.036, p = 0.027, p < 0.001, and p < 0.001
respectively).
Conclusion: Epidural analgesia has deteriorated oxidative stress status and lower neonatal Apgar scores with higher NICU administration
compared with water birth and vaginal birth without pain relief