Relations of east and west between B.C. 1200 - 600

Bu çalışmada Erken Demir Çağ'dan Orientalizan Çağ'a kadar olan süreç içinde arkeolojinin ana materyalleri olan seramik, mimari ve plastik veriler göz önüne alınarak Ege havzası içinde meydana gelen ilişkiler ele alınmıştır.Tezin ilk bölümünde şu ana kadar araştırmacılar tarafından konu üzerine ortaya konan düşünceler tarafsız bir biçimde sunulmuştur. Bunu yaparken, başta dönemin ana kaynak noktası olan seramik veriler, ardından mimari ile ilgili veriler ve son olarak heykelcik alanındaki veriler ele alınmıştır. Bunlar kendi içlerinde bağımsız olarak ele alınmışlardır. Seramik alanında, Protogeometrik ve Geometrik Dönemler alt dönemler olarak ele alınırken, mimari alanında zamansal sınırlamalar kullanılmıştır. Heykelcik alanında yeterli veri olmaması sebebiyle heykelcikler buluntu yerlerine göre sıralanmıştır.Tezin ikinci bölümü bir sonuç kısmı değildir. Bu bölümde, birinci bölümde ele alınan konular eleştirel bir bakış açısıyla ele alınarak eldeki veriler değerlendirilmeye çalışılmıştır. Bu veriler ışığında bu sürecin anlaşılmasında yeni bir bakış açısı yakalanmaya çalışılmıştır.In this study relationships that occured in Aegean Basin were investigated by using ceramic, architectural and plastic data, which are the main materials of archeology for the period from Early Iron Age to Orientalizing Age.During the first part of the thesis, ideas of other researchers were presented in an unbiased way. Ceramic, architectural and scluptural data of the interested period were evaluated as the main source of information, respectiveley and seperately. Protogeometric and Geometric Periods were accepted as subperiods for ceramics, while temporal constraints were used for architectural evaluation. Due to insufficient data for sculptural evaluation, sclupltures were ordered according to their finding area.The second part of the thesis is not a 'results' section. In this section, issues that were presented in the first section were critically evaluated. A new perspective to understand the considered period was tried to be setteled under the light of these data

Alpha/Beta T-Cell Depleted Grafts as an Immunological Booster to Treat Graft Failure after Hematopoietic Stem Cell Transplantation with HLA-Matched Related and Unrelated Donors

Allogeneic hematopoietic stem cell transplantation is associated with several complications and risk factors, for example, graft versus host disease (GVHD), viral infections, relapse, and graft rejection. While high levels of CD3+ cells in grafts can contribute to GVHD, they also promote the graft versus leukemia (GVL) effect. Infusions of extra lymphocytes from the original stem cell donor can be used as a treatment after transplantation for relapse or poor immune reconstitution but also they increase the risk for GVHD. In peripheral blood, 95% of T-cells express the αβ T-cell receptor and the remaining T-cells express the γδ T-cell receptor. As αβ T-cells are the primary mediators of GVHD, depleting them from the graft should reduce this risk. In this pilot study, five patients transplanted with HLA-matched related and unrelated donors were treated with αβ T-cell depleted stem cell boosts. The majority of γδ T-cells in the grafts expressed Vδ2 and/or Vγ9. Most patients receiving αβ-depleted stem cell boosts increased their levels of white blood cells, platelets, and/or granulocytes 30 days after infusion. No signs of GVHD or other side effects were detected. A larger pool of patients with longer follow-up time is needed to confirm the data in this study

Saudi SCD patients’ symptoms and quality of life relative to the number of ED visits

Background Individuals living with sickle cell disease (SCD) have significantly increased emergency department (ED) use compared to the general population. In Saudi Arabia, health care is free for all individuals and therefore has no bearing on increased ED visits. However, little is known about the relationship between quality of life (QoL) and frequency of acute care utilization in this patient population. Methods A cross-sectional study was conducted on 366 patients with SCD who attended the outpatient department at King Fahad Hospital, Hofuf, Saudi Arabia. Data were collected through self-administered surveys, which included: demographics, SCD-related ED visits, clinical issues, and QoL levels. We assessed the ED use by asking for the number of SCD-related ED visits within a 6-month period. Results The self-report survey of ED visits was completed by 308 SCD patients. The median number of SCD-related ED visits within a 6-month time period (IQR) was four (2-7 visits). According to the unadjusted negative binomial model, the rate of SCD-related ED visits increased by (46, 39.3, 40, and 53.5 %) for patients with fever, skin redness with itching, swelling, and blood transfusion, respectively. Poor QoL tends to increase the rate of SCD-related ED visits. Well education and poor general health positively influenced the rate of SCD-related ED visits. Well education tends to increase the rate of SCD-related ED visits by 50.2 %. The rate of SCD-related ED visits decreased by 1.4 % for every point increase in general health. Conclusion Saudi patients with sickle cell disease reported a wide range of SCD-related ED visits. It was estimated that six of 10 SCD patients had at least three ED visits within a 6-month period. Well education and poor general health resulted in an increase in the rate of SCD-related ED visits

The methodology and significance of minimal residual disease detection after allogeneic stem cell transplantation

Allogeneic stem cell transplantation (SCT) is the choice of therapy for leukemia patients who respond poorly to conventional chemotherapy. Despite high remission rates after SCT, relapse of the underlying disease remains one of the most frequent causes of treatment failure. Graftversus-host disease (GVHD), a major complication after SCT, is caused by the activation of alloreactive donor T-cells. Although being life threatening in its severe forms, GVHD has a protective effect called the graft-versus-leukemia effect (GVL). In order to use the GVL effect of donor T-cells, donor lymphocyte infusions (DLI) is now used as a treatment for relapse after SCT. Response to DLI is usually better when the tumor load is low. Therefore, sensitive methods to detect residual leukemic cells are needed in order to identify patients who are at the highest risk of relapse and to start immunotherapeutic interventions when the tumor load is still low. Minimal residual disease (MRD) refers to the presence of leukemic cells below the detection limit of standard morphological analysis. The most sensitive and widely used techniques for MRD detection are based on the PCR technology. The aim of this thesis is to evaluate the clinical significance of MRD detection in leukemia patients receiving SCT. In patients with acute myeloid leukemia (AML), we evaluated the significance of mixed chimerism (MC) analysis, the detection of recipient-derived hematopoietic cells after SCT. MC analysis was performed in the leukemia-affected cell lineage to increase the specificity and sensitivity of the method. MC was detected in 14 of 30 patients. Ten of these 14 patients relapsed as compared to 2 of 16 with donor chimerism (p<0.01). MC was detected a median time of 66 (range 23-332) days before hernatological relapse. Using immunoglobulin and T-cell receptor gene rearrangements as clonal markers, we analyzed MRD levels before and after SCT in patients with acute lymphoblastic leukemia (ALL). MRD detection before SCT was associated with increased risk of relapse. However, GVHD was shown to protect against relapse in patients with high levels of MRD. MRD detection after SCT was also associated with a high risk of relapse. Relapse occurred in 8 of 9 MRD positive patients as compared to 6 of 23 MRD negative patients (p<0.01). MRD was detected a median of 5.5 (range 0.5-30) months before relapse. In recent years, nonmyeloablative SCT (NST) has been studied as a safer approach for patients who are not eligible for the toxic conditioning regimens given before SCT. We studied the kinetics of MRD and MC in chronic myeloid leukemia (CML) patients receiving NST and compared the results to those obtained from CML patients receiving a conventional SCT (CST). A competitive PCR approach was performed for quantitative MRD analysis of BCR-ABL transcripts. In the early posttransplant period, higher incidence and levels of MC and MRD were found in NST patients as compared to CST patients. However, molecular remissions were subsequently achieved in most NST patients. Wilms tumor gene (WTI) has been reported as a "panleukemic" MRD marker in many studies. We wanted to evaluate WTI as a MRD marker by comparing the kinetics of WTI levels with that of BCR- ABL using realtime quantitative PCR. We found a background expression of WTI healthy controls. In addition, WTI analysis was not sensitive enough to predict relapse. In conclusion, MRD analysis in leukemia patients provides the possibility to identify patients at high risk of relapse after SCT. Adoptive immunotherapy based on MRD results may prevent relapse and improve outcome for patients with poor prognosis

Avrupa muhaceretindeki Türkistan Basını : Milli Türkistan Dergisi (1942-1975)

Millî Türkistan dergisi, Millî Türkistan Birlik Komitesi’nin yayın organı olarak 15 Haziran 1942’de yayın hayatına başlamıştır. Bu dönem itibariyle dergi, üç ayrı dönemde çıkmış, sonra yıllar süren uzun aralar vermiş ve sayıları birbirini takip etmiştir. Derginin çıkış dönemleri, 1942-45, 1949-54, 1962-75 yılları arasındadır. Avrupa muhaceretinde bulunan Türkistanlıların Sovyetlerin Türkistan üzerindeki şekillendirmelerine karşı basın-yayın yoluyla Sovyetlere karşı millî istiklal mücadelesi vermesi bakımından oldukça önemlidir. Ayrıca, muhacerette bulunan Türkistanlıların çıkardığı en uzun soluklu dergidir. 1942-1975 yılları arasında Türkistan’da neler yaşandığını, Sovyet Rusya’nın Türkistan’a nasıl bir şekil vermek istediğini ve Türkistanlıların Rusya’nın bu siyasetine bakışlarını bu dergi sayesinde öğrenebilme imkânına sahibiz. Bu kadar önemli olmasına rağmen, daha önce bu dergi incelenmemiştir. Araştırmada, dergiyi baştan sona okumak ve analitik lerini yapmak suretiyle öncelikle tüm görüntü ortaya çıkarılmış, arkasından dergi yazarları ve derginin içeriği analiz edilmiştir. Abstract Millî Türkistan was an organ of Millî Türkistan Birlik Komitesi, a politican and cultural organization po Türkistani emigrees in Europa. The journal began its publication in the 15th of June, 1942, in Berlin (later, in Genevre, then in Duesseldorf). It was published in intervels, first in 1942-45, then in 1949-54, and finally in 1962-75. The journal is very important in terms of understanding the shaping of Soviet policy during these periods. It gives us an understanding from both outside and inside information. This was an emigre journal of Turkistanian intellectuals. It was also the longest living journal of Turkestani immigrants living in Europe. This research, first analyzed all the articles of the journal, then researched the biographies of the writers of the journal. Finally, this research analyzed the contents of the journal throughtly

Normotansif mikroalbuminürili tip 2 diabetiklerde klortalidon, losartan ve perindopril'in mikroalbuminüri üzerine karşılaştırmalı etkisi

Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.[Abstarct Not Available

Lise öğrencilerinin anne-baba tutumları ile mükemmeliyetçi öz-sunum düzeyleri arasındaki ilişkinin incelenmesi (Kocaeli İli örneği)

ÖZETBu çalışmanın amacı, Kocaeli’nde öğrenim gören lise öğrencilerinin algıladıkları anne-baba tutumları ile mükemmeliyetçi öz-sunum düzeyleri arasındaki ilişkiyi ortaya koymaktır. İlişkisel tarama modelinde hazırlanan araştırmanın örneklem grubunu, 2013-2014 eğitim-öğretim yılında Kocaeli’nde bulunan Milli Eğitim Bakanlığı’na bağlı farklı türdeki resmi liselerden, yansız oransız küme örnekleme yöntemiyle seçilen 428 lise öğrencisi oluşturmuştur.Araştırmada, araştırmacı tarafından hazırlanan Kişisel Bilgi Formu, çocuk ve ergenlerin mükemmeliyetçi öz-sunum düzeylerini belirlemek amacıyla Hewitt ve diğerleri (2011) tarafından geliştirilen ve Akın & Akın (2012) tarafından Türkçe’ye uyarlanan “Çocuk ve Ergenlerde Mükemmeliyetçi Öz-sunum Ölçeği”; ergenler ve yetişkinler için anne-babalarının tutumlarını ölçmek amacıyla Kuzgun (1972) tarafından geliştirilen, Kuzgun ve Eldeleklioğlu (1993; 2005) tarafından revize edilmiş olan “Anne-Baba Tutumları Ölçeği” kullanılmıştır.Araştırmada betimsel analizler, bağımsız grup t testi, tek yönlü varyans analizi (ANOVA) ve Pearson Korelasyon Analizi ile gerçekleştirilmiştir. Yapılan araştırma sonucunda, “demokratik tutum” ile mükemmeliyetçi öz-sunum ölçeği “hatanın söylenmemesi” alt boyutu arasında negatif yönde anlamlı bir ilişki bulunmuştur (p<,001). “Koruyucu-istekçi tutum” ve “otoriter tutum” ile mükemmeliyetçi öz-sunum ölçeği toplam puan ve tüm alt boyutları arasında ise pozitif yönde anlamlı bir ilişki bulunmuştur (p<,001).Araştırmada öğrencilerin mükemmeliyetçi öz-sunum düzeylerinin, araştırmanın süreksiz değişkenlerinden yaş, sınıf, cinsiyet ve okul türüne göre farklılaştığı tespit edilmiştir.Araştırmada öğrencilerin anne-baba tutumlarının, araştırmanın süreksiz değişkenlerinden yaş, sınıf, cinsiyet, okul türü, baba eğitim düzeyi ve kardeş sayısı değişkenlerine göre farklılaştığı bulunmuştur.Anahtar kelimeler: Anne-baba tutumları, mükemmeliyetçi öz-sunum, lise öğrencileriABSTRACTThe aim of this study is to reveal the relationship between perceived parental attitudes and perfectionist self-presentation levels of high school students who study in Kocaeli. The correlational survey method was used and the sample consisted of 428 high school students from different types of official high schools affiliated with Ministiry of National Education during the 2013–2014 academic year in Kocaeli and selected by disproportionate random cluster sampling method.In the study the following measurment tools were used; Personal information form which was prepared by the researcher, in order to determine Perfectionistic Self-presentation levels of Children and Adolescents “Perfectionistic Self-presentation in Children and Adolescents Scale” which was developed by Hewitt et.al. (2011) and adapted to Turkish by Akın & Akın (2012), Parental Attitudes Scale for measuring parents’ attitudes of adolescents and adults developed by Kuzgun (1972) and revised by Kuzgun and Eldeleklioğlu (1993; 2005).In the study descriptive analysis was performed by independent group t-test, one way analysis of variance (ANOVA) and Pearson correlation analysis.As a result of the research, there was a significantly negative relationship between “democratic attitude” with Nondisclosure of Imperfection sub-scale of the perfectionist self-presentation scale (p<,001). It was found that there was a significantly positive relationship between “protective-requester attitude” and “authoritarian attitude” with perfectionist self-presentation scale total score and all its sub-scales (p<,001).Findings showed that perfectionistic self-presentation levels of students differ in terms of discrete variables in the study such as age, class, gender and type of school.Findings revealed that parental attitudes of students differ in terms of discrete variables in the study such as age, class, gender, type of school, father’s education level, number of siblings.Key words: parental attitudes, perfectionistic self-presentation, high school student

Lise öğrencilerinin anne-baba tutumları ile mükemmeliyetçi öz-sunum düzeyleri arasındaki ilişkinin incelenmesi (Kocaeli İli örneği)

Bu çalışmanın amacı, Kocaeli’nde öğrenim gören lise öğrencilerinin algıladıkları anne-baba tutumları ile mükemmeliyetçi öz-sunum düzeyleri arasındaki ilişkiyi ortaya koymaktır. İlişkisel tarama modelinde hazırlanan araştırmanın örneklem grubunu, 2013-2014 eğitim-öğretim yılında Kocaeli’nde bulunan Milli Eğitim Bakanlığı’na bağlı farklı türdeki resmi liselerden, yansız oransız küme örnekleme yöntemiyle seçilen 428 lise öğrencisi oluşturmuştur. Araştırmada, araştırmacı tarafından hazırlanan Kişisel Bilgi Formu, çocuk ve ergenlerin mükemmeliyetçi öz-sunum düzeylerini belirlemek amacıyla Hewitt ve diğerleri (2011) tarafından geliştirilen ve Akın & Akın (2012) tarafından Türkçe’ye uyarlanan “Çocuk ve Ergenlerde Mükemmeliyetçi Öz-sunum Ölçeği”; ergenler ve yetişkinler için anne-babalarının tutumlarını ölçmek amacıyla Kuzgun (1972) tarafından geliştirilen, Kuzgun ve Eldeleklioğlu (1993; 2005) tarafından revize edilmiş olan “Anne-Baba Tutumları Ölçeği” kullanılmıştır. Araştırmada betimsel analizler, bağımsız grup t testi, tek yönlü varyans analizi (ANOVA) ve Pearson Korelasyon Analizi ile gerçekleştirilmiştir. Yapılan araştırma sonucunda, “demokratik tutum” ile mükemmeliyetçi öz-sunum ölçeği “hatanın söylenmemesi” alt boyutu arasında negatif yönde anlamlı bir ilişki bulunmuştur (p<,001). “Koruyucu-istekçi tutum” ve “otoriter tutum” ile mükemmeliyetçi öz-sunum ölçeği toplam puan ve tüm alt boyutları arasında ise pozitif yönde anlamlı bir ilişki bulunmuştur (p<,001). Araştırmada öğrencilerin mükemmeliyetçi öz-sunum düzeylerinin, araştırmanın süreksiz değişkenlerinden yaş, sınıf, cinsiyet ve okul türüne göre farklılaştığı tespit edilmiştir. Araştırmada öğrencilerin anne-baba tutumlarının, araştırmanın süreksiz değişkenlerinden yaş, sınıf, cinsiyet, okul türü, baba eğitim düzeyi ve kardeş sayısı değişkenlerine göre farklılaştığı bulunmuştur. Anahtar kelimeler: Anne-baba tutumları, mükemmeliyetçi öz-sunum, lise öğrencileri ABSTRACT The aim of this study is to reveal the relationship between perceived parental attitudes and perfectionist self-presentation levels of high school students who study in Kocaeli. The correlational survey method was used and the sample consisted of 428 high school students from different types of official high schools affiliated with Ministiry of National Education during the 2013–2014 academic year in Kocaeli and selected by disproportionate random cluster sampling method. In the study the following measurment tools were used; Personal information form which was prepared by the researcher, in order to determine Perfectionistic Self-presentation levels of Children and Adolescents “Perfectionistic Self-presentation in Children and Adolescents Scale” which was developed by Hewitt et.al. (2011) and adapted to Turkish by Akın & Akın (2012), Parental Attitudes Scale for measuring parents’ attitudes of adolescents and adults developed by Kuzgun (1972) and revised by Kuzgun and Eldeleklioğlu (1993; 2005). In the study descriptive analysis was performed by independent group t-test, one way analysis of variance (ANOVA) and Pearson correlation analysis. As a result of the research, there was a significantly negative relationship between “democratic attitude” with Nondisclosure of Imperfection sub-scale of the perfectionist self-presentation scale (p<,001). It was found that there was a significantly positive relationship between “protective-requester attitude” and “authoritarian attitude” with perfectionist self-presentation scale total score and all its sub-scales (p<,001). Findings showed that perfectionistic self-presentation levels of students differ in terms of discrete variables in the study such as age, class, gender and type of school. Findings revealed that parental attitudes of students differ in terms of discrete variables in the study such as age, class, gender, type of school, father’s education level, number of siblings. Key words: parental attitudes, perfectionistic self-presentation, high school student

Performance Comparison between Encrypted and Unencrypted Time Series Databases with IoT-Based Temperature and Geolocation Data

Internet of Things (IoT) är en växande teknologi som spelar en allt större roll i samhället. Den innefattar ett nätverk av internetanslutna enheter som samlar in och utbyter data. Samtidigt som IoT växer uppstår utmaningar kring hantering av stora datamängder och säkerhetsaspekter. Företaget Softhouse står inför utmaningen att välja en effektiv tidsseriedatabas för hantering av temperatur- och geopositionsdata från värmesystem i privata bostäder, där både prestanda och dataintegritet via kryptering är av stor vikt. Detta examensarbete har därför utfört en prestandajämförelse mellan AWSTimestream och InfluxDB, där olika tester har använts för att mäta exekveringstiden för inskrivning av sensordata och databasfrågor. Jämförelsen inkluderar AWS Timestream i krypterad form mot InfluxDB i dess AWS-molnversion i krypterad form, samt InfluxDB AWS i krypterad form mot InfluxDB i okrypterad form. Syftet med studien var att ge riktlinjer för valet av tidsseriedatabaser med fokus på prestanda och säkerhetsaspekter, inklusivekryptering. Studien undersökte även hur valet av rätt databas påverkar företag som Softhouse, både i termer av kvantitativa och kvalitativa fördelar, samt att ge en bedömning av kostnaderna. Resultatet visade att InfluxDB i dess AWS-molnversion generellt presterade bättre än AWS Timestream och InfluxDB i dess standardversion. Det fanns tydliga skillnader i prestanda mellan AWS Timestream och InfluxDB i dess AWS-molnversion, men inte lika tydliga skillnader i prestanda mellan InfluxDB i dess AWS-molnversion och standardversionen. Med hänsyn till både prestanda och säkerhet framstår InfluxDB i dess AWS-molnversion som det mest lämpliga alternativet. Det är emellertid av stor vikt att ta kostnadaspekten i beaktande, då AWS Timestream visar sig vara avsevärt mer kostnadseffektivt än InfluxDB.The Internet of Things (IoT) is a growing technology that plays an increasingly significant role in society. It encompasses a network of internet-connected devices that collect and exchange data. As IoT continues to expand, challenges arise regarding the management of large volumes of data and security aspects. The company Softhouse faces the challenge of choosing an efficient time-series database for handling temperature and geoposition data from heating systems in homes, where both performance and data integrity through encryption are of great importance. Therefore, this thesis has conducted a performance comparison between AWS Timestream and InfluxDB, using various tests to measure the execution times for data ingestion of sensor data and database queries. The comparison includes AWS Timestream in encrypted form versus InfluxDB in its AWS cloud version in encrypted form, as well as InfluxDB AWS in encrypted form versus InfluxDB in unencrypted form. The aim of the study was to provide guidelines for the selection of time-series databases with a focus on performance and security aspects, including encryption. The study also explored how the choice of the right database affects companies like Softhouse, both in terms of quantitative and qualitative benefits, and provided an assessment of costs. The results showed that InfluxDB in its AWS cloud version generally outperformed AWS Timestream and InfluxDB in its standard version. There were clear performance differences between AWS Timestream and InfluxDB in its AWS cloud version, but not as pronounced differences in performance between InfluxDB in itsAWS cloud version and the standard version. Considering both performance and security, InfluxDB in its AWS cloud version appears to be the most suitable option. However, it is crucial to consider the cost aspect, as AWS Timestream proves to be significantly more cost-effective than InfluxDB