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Taha Toros Arşivi, Dosya No: 8-Va-Nu (Vala Nurettin)Unutma İstanbul projesi İstanbul Kalkınma Ajansı'nın 2016 yılı "Yenilikçi ve Yaratıcı İstanbul Mali Destek Programı" kapsamında desteklenmiştir. Proje No: TR10/16/YNY/010

Hadi uyan Metin Abi!

Taha Toros Arşivi, Dosya No: 119-Metin Toker. Not: Gazetenin “Ada” köşesinde yayımlanmıştır.Unutma İstanbul projesi İstanbul Kalkınma Ajansı'nın 2016 yılı "Yenilikçi ve Yaratıcı İstanbul Mali Destek Programı" kapsamında desteklenmiştir. Proje No: TR10/16/YNY/010

ATXN2 and its neighbouring gene SH2B3 are associated with increased ALS risk in the Turkish population

Expansions of the polyglutamine (polyQ) domain (≥34) in Ataxin-2 (ATXN2) are the primary cause of spinocerebellar ataxia type 2 (SCA2). Recent studies reported that intermediate-length (27–33) expansions increase the risk of Amyotrophic Lateral Sclerosis (ALS) in 1–4% of cases in diverse populations. This study investigates the Turkish population with respect to ALS risk, genotyping 158 sporadic, 78 familial patients and 420 neurologically healthy controls. We re-assessed the effect of ATXN2 expansions and extended the analysis for the first time to cover the ATXN2 locus with 18 Single Nucleotide Polymorphisms (SNPs) and their haplotypes. In accordance with other studies, our results confirmed that 31–32 polyQ repeats in the ATXN2 gene are associated with risk of developing ALS in 1.7% of the Turkish ALS cohort (p = 0.0172). Additionally, a significant association of a 136 kb haplotype block across the ATXN2 and SH2B3 genes was found in 19.4% of a subset of our ALS cohort and in 10.1% of the controls (p = 0.0057, OR: 2.23). ATXN2 and SH2B3 encode proteins that both interact with growth receptor tyrosine kinases. Our novel observations suggest that genotyping of SNPs at this locus may be useful for the study of ALS risk in a high percentage of individuals and that ATXN2 and SH2B3 variants may interact in modulating the disease pathway

Utilization of Legal Education Digitalization for Village Heads in Empowering Village Owned Enterprises

Most of Indonesia's population lives in rural areas, for this reason it is necessary to prioritize development to improve public services and the village economy in order to form individuals and communities to become self-reliant. One of the government's efforts is to implement a village digitization program. Digitalization through the use of this technology really needs to be implemented on a micro-scale development located in rural areas such as village-owned enterprises. The research method used is descriptive research. The results of the study show that digitalization of legal education has a very crucial role for the village head in empowering Village-Owned Enterprises (BUMDes), one of which will increase sufficient capacity and knowledge so that they can properly run and empower BUMDes. In addition to technical skills such as accounting and managerial skills, character-deepening training is also needed in order to produce honest and trustworthy BUMDes staff managers. BUMDes specifically cannot be equated with legal entities such as limited liability companies or cooperatives. in conclusion, the status of BUMDes after the issuance of Law Number 11 of 2020 concerning Job Creation, namely as a New Entity Legal Entity whose position is equivalent to BUMN at the national level and BUMD at the regional level

Analysis of Relationship Marketing Tactics at PT. Bank Sulut Tutuyan

Today, most of customers are getting smarter, more informed, and they are free to choose which they would like to take little time to exercise. They can easily defect to competitors who fulfill their expectations. That is why company must have strategy to retain customer loyalty and relationship marketing tactics can be applied to solve this problem. The objectives that expected can be achieved from this study are to analyze relationship marketing tactic based on service quality, price perception, brand image, and communication at PT.BankSulutTutuyan. Theories supporting research are marketing and relationship marketing tactics. The population that is mainly observed in this research is all of the customers of Bank SulutTutuyan with sample of 10 customers as respondents and representative to provide information required in this research. Results and conclusions are most of respondents give positive responses about service quality, price perception, brand image, and communication delivered by employees. Keywords: relationship marketing tactics, service quality, price perception, brand image, communicatio

Subtle but significant effects of CO<inf>2</inf> acidified seawater on embryos of the intertidal snail, Littorina obtusata

Our understanding of the effects of ocean acidification on whole organism function is growing, but most current information is for adult stages of development. Here, we show the effects of reduced pH seawater (pH 7.6) on aspects of the development, physiology and behaviour of encapsulated embryos of the marine intertidal gastropod Littorina obtusata. We found reduced viability and increased development times under reduced pH conditions, and the embryos had significantly altered behaviours and physiologies. In acidified seawater, embryos spent more time stationary, had slower rotation rates, spent less time crawling, but increased their movement periodicity compared with those maintained under control conditions. Larval and adult heart rates were significantly lower in acidified seawater, and hatchling snails had an altered shell morphology (lateral length and spiral shell length) compared to control snails. Our findings show that ocean acidification may have multiple, subtle effects during the early development of marine animals that may have implications for their survival beyond those predicted using later life stages. © Inter-Research 2009

Radio Polarization from the Galactic Plane in Cygnus

We present 1420 MHz (lambda=21cm) observations of polarized emission from an area of 117 degree square in the Galactic plane in Cygnus, covering 82 < l < 95, -3.5 < b < +5.5, a complex region where the line of sight is directed nearly along the Local spiral arm. The angular resolution is ~ 1', and structures as large as 45' are fully represented in the images. Polarization features bear little resemblance to features detected in total power: while the polarized signal arises in diffuse Galactic synchrotron emission regions, the appearance of the polarized sky is dominated by Faraday rotation occurring in small-scale structure in the intervening Warm Ionized Medium. There is no concentration of polarization structure towards the Galactic plane, indicating that both the emission and Faraday rotation occur nearby. We develop a conceptual framework for interpretation of the observations. We can detect only that polarized emission which has its origin closer than the polarization horizon, at a distance d_ph; more distant polarized emission is undetectable because of depth depolarization (differential Faraday rotation) and/or beam depolarization (due to internal and external Faraday dispersion). d_ph depends on the instrument used (frequency and beamwidth) as well as the direction being studied. In our data we find that d_ph ~ 2 kpc, consistent with the polarization features originating in the Local arm

ALIH KODE PERCAKAPAN TIDAK RESMI MAHASISWA PRODI PENDIDIKAN BAHASA DAN SASTRA INDONESIA FAKULTAS SASTRA DAN BUDAYA UNIVERSITAS NEGERI GORONTALO

Penelitian ini bertujuan untuk mendeskripsikan bentuk alih kode percakapan tidak resmi mahasiswa Prodi Pendidikan Bahasa dan Sastra Indonesia Fakultas Sastra dan Budaya Universitas Negeri Gorontalo, dan mendeskripsikan tujuan penutur menggunakan alih kode percakapan tidak resmi mahasiswa Prodi Pendidikan Bahasa dan Sastra Indonesia Fakultas Sastra dan Budaya Universitas Negeri Gorontalo. Penelitian ini menggunakan kajian alih kode yaitu teori yang mengungkap perubahan pemakaian jenis bahasa. Metode penelitian ini adalah metode deskriptif kualitatif. Data penelitian berupa tuturan yang terjadi dilingkungan mahasiswa Prodi Pendidikan Bahasa dan Sastra Indonesia, FSB-UNG yang mengalami alih kode. Teknik pengumpulan data menggunakan teknik simak libat cakap dan teknik rekam. Teknik analisis data dilakukan dengan cara menyalin atau mentranskripsi, menerjemahkan, mengidentifikasi, menganalisis. Hasil penelitian dan pembahasan menunjukkan bahwa terdapat data berupa kata, frasa, klausa, dan kalimat dari penutur yang mengandung unsur-unsur alih kode dalam pecakapan tidak resmi mahasiswa Prodi Pendidikan Bahasa dan Sastra Indonesisa Fakultas Sastra dan Budaya Universitas Negeri Gorontalo. Data pun menunjukkan alih kode yang terjadi tergolong dalam 7 jenis alih kode, yaitu alih kode intern, alih kode ekstern, alih kode menegaskan suatu hal untuk meyakinkan, mengakrabkan diri, menghormati mitra tutur, mengubah situasi humor, meningkatkan gengsi. Kata-kata kunci: Alih kode, percakapan, mahasiswa, pendidikan, bahasa