HYPOGONADOTROPIC HYPOGONADISM (REVIEW)

The review is dedicated to the problem of hypogonadotropic hypogonadism. Modern ideas of the stages of normal sexual development of girls, etiology and pathogenesis of constitutional arrest of sexual development and hypogonadotropic hypogonadism are presented. Modern approaches to the treatment of this condition using hormone replacement therapy and non-hormonal agents are considered.Key words: hypogonadotropic hypogonadism, sexual development arrest, treatment, hormone replacement therapy

HYPOGONADOTROPIC HYPOGONADISM (REVIEW)

The review is dedicated to the problem of hypogonadotropic hypogonadism. Modern ideas of the stages of normal sexual development of girls, etiology and pathogenesis of constitutional arrest of sexual development and hypogonadotropic hypogonadism are presented. Modern approaches to the treatment of this condition using hormone replacement therapy and non-hormonal agents are considered.Key words: hypogonadotropic hypogonadism, sexual development arrest, treatment, hormone replacement therapy

Rational choice of the combined oral contraceptive for the prevention of unplanned pregnancy in women of early reproductive age. The advantage of a combination of hormones and folates

Rational choice of the combined oral contraceptive for the prevention of unplanned pregnancy in women of early reproductive age. The advantage of a combination of hormones and folates Uvarova E.V. The problem of protecting the general and reproductive health of young people is very important, especially in modern conditions. The foundation of the health of a woman of childbearing age is laid from the first days of her life. The article presents the general picture of women’s reproductive health and the factors affecting it. The role of vitamins and minerals in the regulation of the menstrual cycle is highlighted. The effectiveness of the use of folic acid preparations, in particular Metafolin®, is demonstrated at the stage of pregravid preparation and during pregnancy in order to prevent congenital malformations and complications of gestation. The article shows that the use of combined oral contraceptives brings a variety of therapeutic actions to the woman’s body and is an effective measure for the prevention of many chronic diseases and conditions. The use of drospirenone-containing microdosed hormonal contraceptives with folates in their composition is currently topical. Metafolin® in the microdosage hormone contraceptive Yas® plus to some extent compensates for the folate concentration necessary to prevent neural tube defects in the fetus in the 27-30 days of pregnancy, which is confirmed by numerous clinical studies. Key words: reproductive age, menstruation disorders, combined oral contraceptives, neural tube defects, Metafolin, folates. For citation: Uvarova E.V. Rational choice of the combined oral contraceptive for the prevention of unplanned pregnancy in women of early reproductive age. The advantage of a combination of hormones and folates // RMJ. 2018. № 5(I). P. 33–36.<br

OVARIAN RESERVE IN HEALTHY ADOLESCENT GIRLS

Preserving reproductive health of girls is a pressing issue for the modern healthcare industry. The purpose of this study was to determine the metrics of ovarian reserve in healthy adolescent girls aged 15 to 17 in the Republic of Mordovia. 49 healthy adolescent girls aged 15 to 17 were examined in the study. A medical and social audit was conducted at the first state to study their medical history and hereditary factors. Their physical and sexual development (sexual form, characteristic of menstrual cycle, general and gynecological exam) was assessed at the second stage. Hormonal status and ovarian reserve metrics were examined at the third stage. Ultrasonic examination of pelvic organs was conducted and concentrations of LH, FSH, estradiol and anti-Mullerian hormone (AMH) in blood were determined. The study results obtained suggest that a reduced size of ovary in girls aged 16 compared with 15-year-old girls is accompanied with the tendency toward a reduced level of AMH and increased concentration of FSH in blood serum. A significant increase in the average size of both ovaries in 17-year-old adolescents is accompanied with the tendency toward increased AMH, and, by contrast, the tendency toward a reduced level of FSH. The level of estradiol significantly increases over age, i.e. over the period from 15 to 17 years. Hence, at ages 15 and 16 all reproductive system components continue to actively adjust to cyclical functioning. By age 17, a close relationship between ovarian reserve and hormonal status is established.Key words: reproductive health, ovarian reserve, hormonal status, girls. (Pediatric Pharmacology. – 2010; 7(5):38-43

OVARIAN RESERVE IN HEALTHY ADOLESCENT GIRLS

Preserving reproductive health of girls is a pressing issue for the modern healthcare industry. The purpose of this study was to determine the metrics of ovarian reserve in healthy adolescent girls aged 15 to 17 in the Republic of Mordovia. 49 healthy adolescent girls aged 15 to 17 were examined in the study. A medical and social audit was conducted at the first state to study their medical history and hereditary factors. Their physical and sexual development (sexual form, characteristic of menstrual cycle, general and gynecological exam) was assessed at the second stage. Hormonal status and ovarian reserve metrics were examined at the third stage. Ultrasonic examination of pelvic organs was conducted and concentrations of LH, FSH, estradiol and anti-Mullerian hormone (AMH) in blood were determined. The study results obtained suggest that a reduced size of ovary in girls aged 16 compared with 15-year-old girls is accompanied with the tendency toward a reduced level of AMH and increased concentration of FSH in blood serum. A significant increase in the average size of both ovaries in 17-year-old adolescents is accompanied with the tendency toward increased AMH, and, by contrast, the tendency toward a reduced level of FSH. The level of estradiol significantly increases over age, i.e. over the period from 15 to 17 years. Hence, at ages 15 and 16 all reproductive system components continue to actively adjust to cyclical functioning. By age 17, a close relationship between ovarian reserve and hormonal status is established.Key words: reproductive health, ovarian reserve, hormonal status, girls. (Pediatric Pharmacology. – 2010; 7(5):38-43

CERVICAL CANCER IS NOT A CHILDREN'S ILLNESS, ISN'T IT?

The authors highlight the foreign authors review about the spread and peculiarities of the HPV infection and HPV'associated uterine cervix impairment in teenage girls. The interaction between HPV infection and uterine cervix impairment were described. There are also the most important prevention approaches in this issue. Key words: human papilloma virus, uterine cervix impairment, cervical cancer, screening, vaccination, teenage girls

CRITICAL ISSUES OF PAPILLOMA VIRUS INFECTION PREVENTION

The article details the issue of malignancy caused by human papilloma virus (HPV), as well as characteristics of this virus. Its genetic stability allows for efficient prevention of this pathology through vaccination. 2 vaccines, which are approved by the FDA end EMEA for use and are registered in Russia, have been created and are successfully used for this purpose. The authors believe that the best results may be achieved by combining screening examination programmes with universal reasonable administration of scheduled voluntary vaccination of Russia’s population.Key words: human papilloma virus, HPV infection, cervical cancer, malignancies, prevention, vaccination

MAIN PRINCIPLES OF TREATMENT OF GENITAL CHLAMYDIOSES AND MYCOPLASMOSES AMONG GIRLS

The article deals with the recommendations based on modern literature and own experience in treatment of girls, suffering from inflammatory genital diseases of chlamydia and mycoplasmal etiology. The authors examined the prescription principles of etiological, pathogenetic and symptomatic therapy, determination of terms for the therapy, criteria of chlamydiosis and genital mycoplasmosis cure, as well as backset prevention, reinfection and complications.Key words: chlamydiosis, genital mycoplasmoses, children, teenagers, treatment

MAIN PRINCIPLES OF TREATMENT OF GENITAL CHLAMYDIOSES AND MYCOPLASMOSES AMONG GIRLS

The article deals with the recommendations based on modern literature and own experience in treatment of girls, suffering from inflammatory genital diseases of chlamydia and mycoplasmal etiology. The authors examined the prescription principles of etiological, pathogenetic and symptomatic therapy, determination of terms for the therapy, criteria of chlamydiosis and genital mycoplasmosis cure, as well as backset prevention, reinfection and complications.Key words: chlamydiosis, genital mycoplasmoses, children, teenagers, treatment