Risk estimation in international futures markets : an anaysis of trading/non-trading time and information effects.

ManagementDoctor of Philosophy (Ph.D.

Analysis of a nuclear complex of proteins that form a spindle matrix during mitosis in Drosophila

A spindle matrix is a macromolecular structure hypothesized to provide a stationary support or strut for the anchorage of motor proteins during force generation, microtubule sliding, and chromosome segregation in mitosis. Previous work in Drosophila has shown Skeletor, as the first putative molecular candidate of spindle matrix structure since it possesses many features consistent with the proposed spindle matrix structure.;We have identified two more putative spindle matrix candidate proteins, Chromator and Megator, using yeast two-hybrid interaction assay, cross-immunoprecipitation and immunocytochemistry. Chromator is a novel and essential chromodomain containing protein that interacts directly with Skeletor and extensively colocalizes with it throughout the cell cycle. During interphase Chromator colocalizes with Skeletor on the chromosomes, and then redistributes on to the Skeletor defined spindle during metaphase and anaphase. Furthermore, RNAi depletion of Chromator in S2 cells leads to abnormal microtubule spindle morphology and to chromosome segregation defects, thus suggesting that Chromator plays a role in proper spindle dynamics during mitosis. We have generated new Chromator mutant alleles to further aid in the functional analysis of its roles in force production and chromosome segregation during mitosis.;Megator (Bx34 antigen) is a Drosophila Tpr ortholog and has an extended N-terminal coiled-coil domain. During interphase Megator is localized to the nuclear rim and occupies the intranuclear space surrounding the chromosomes. However, during mitosis Megator reorganizes and aligns together with Skeletor and Chromator into a fusiform spindle structure. The Megator metaphase spindle persists in the absence of microtubule spindles, thus strongly implying that the existence of the Megator-defined spindle does not require polymerized microtubules. Furthermore, deletion construct analysis in S2 cells revealed that the NH2-terminal coiled-coil region of Megator self assembles into large spheres indicating its ability to form polymers and serve as the structural basis for the putative spindle matrix complex

Perancangan Arsitektur Enterprise e-Health Management System(EHMS) dengan Menggunakan TOGAF Architecture Development Method Studi Kasus : Kementrian Kesehatan Republik Indonesia

ABSTRAKSI: Proses pencatatan rekam medis melibatkan berbagai stakeholder dan melalui beberapa proses bisnis yang dilakukan oleh masing-masing stakeholder tersebut. Pada Tugas Akhir kali ini, dihasilkan suatu rekomendasi perancangan EA sistem pencatatan rekam medis yang terjadi di UPT Puskesmas Kopo, Dinas Kesehatan Kota Bandung dan Kementerian Kesehatan menggunakan konsep Enterprise Architecture (EA). Sistem yang diberi nama e-Health Management System ini akan menggunakan rekam medis atau Electronic Health Record (EHR) sebagai salah satu komponen utama dan dirancang menggunakan metode TOGAF ADM. ADM merupakan proses yang iteratif, dinamis dan berkelanjutan. Fase yang digunakan dalam perancangan ini adalah mulai dari fase preliminary hingga fase Opportunities and Solutions (Fase E). Definisi elemen EA dalam penelitian ini adalah arsitektur bisnis, arsitektur data, arsitektur aplikasi dan arsitektur teknologi. Proses penelitian yang dilakukan dalam Tugas Akhir ini adalah dengan melakukan pengamatan terhadap sistem yang sudah berjalan (baseline) untuk kemudian dihasilkan sistem usulan (target) kemudian dilakukan analisa gap di antara kedua elemen tersebut dan dilakukan pengujian terhadap sistem target menggunakan EA Scorecard.Kata Kunci : e-Health Management System, EHR, EA, TOGAF ADM, EA ScorecardABSTRACT: The process of record medical records involves various stakeholders and also going through multiple businesses performed by each stakeholder. The final project will produce a proposal on architectural design enterprise medical record system of records that occurred at UPT Puskesmas Kopo, Dinas Kesehatan Kota Bandung and Kementerian Kesehatan uses the concept of Enterprise Architecture (EA). The whole system, called e-Health Management System, will use medical record or Electronic Health Record (EHR) as one of its key component and using TOGAF ADM method to build it. ADM is an iterative, dynamic and sustainable process. Phases used in the design are the preliminary phase to the Opportunities and Solutions (phase E). Definitions of EA element in this study are business architecture, data architecture, application architecture and technology architecture. The process of research conducted in this final project is to make observations of the system that has been running (baseline), produce a proposed system (target) then performed a gap analysis between those two elements and then testing the target system using EA ScorecardKeyword: e-health management system, EHR, EA, TOGAF ADM. EA Scorecar

Spatial estimation of the nexus between the PRC's foreign direct investment and ASEAN's growth

Forging closer economic relations between the People's Republic of China (PRC) and the Association of Southeast Asian Nations (ASEAN) over the last 2 decades has contributed to building a stronger ASEAN economy. It is particularly important to know how the PRC's foreign direct investment responds to ASEAN's economic performance. This study investigates the causal relationship between the PRC's foreign direct investment and economic growth among the 10 ASEAN member countries from 1995 to 2013. Panel unit root tests, a spatial panel vector autoregressive model, and spatial Granger causality are employed as empirical techniques for spatial panel estimation. The empirical results reveal that the PRC's direct investment in ASEAN caused economic growth in ASEAN, and economic growth in ASEAN resulted in the PRC's direct investment in ASEAN. This finding raises potentially interesting external investment policy implications

Various sacral indices: role in study of sexual dimorphism

Background: Skeleton is an excellent material in living and non-living population for genetic, anthropological and forensic investigations. Sound anatomical knowledge of human osteology in the evaluation of death may help to shed light on legal issues such as sex and age determination, parentage and racial identity. It has widely recognized that skeletal characters vary among different racial groups and even within the same racial groups. Sacrum is one of the commonest part of skeleton used to opine the sex. The study documents effort to determine sex by using different measurements of the sacrum and calculating the different indices based on these measurements. The most useful aspect of such study is to evaluate the role of different indices of sacrum in sex determination.Methods: Study was carried out on 141 adult, dry sacra in Department of Anatomy, BVDU Medical College, Pune. 141 sacra were classified into male and female bones by observing the parameters like - length of sacrum, width of sacrum, transverse diameter of body of S1, anteroposterior diameter of S1, length of ala of sacrum.Results: The indices like sacral index, curvature index, corpobasal index and alar Index were found to be statistically significant with p value 0.05 and was statistically not significant.Conclusions: The most useful aspect of such studies was to determine appropriate indices of sexual dimorphism for sacral bone. The study concluded that no single index can identify sex of sacrum with 100% accuracy. So multiple indices should be used for determination of sex by sacrum with 100% accuracy.

Robustness of the EWMA Sampling Plan to Non-Normality

The effect of non-normality on the OC function of the sampling plan under EWMA is studied by deriving the OC function for a non-normal population represented by the first four terms of an Edgeworth series

The changing nature of urban public places in Dhaka City

Throughout the history, public places have been asserted as one of the key components of urban life for their physical, social, political, symbolic and environmental roles. However, the nature and quality of public places in recent years have raised the question how far these places remain ‘public’ in true sense. The study systematically explores how the public places of Dhaka have transformed throughout the history in different time periods. It attempts to assess the ‘publicness’ of the existing public places focusing on the changing nature of these places and the tensions arise from different perspectives. The research is descriptive and employs a case study approach. Osmany Uddan, a park situated in the prime location in the city center and the Hatirjheel, a recently developed lakeside area, have been considered as two cases. The findings from the case studies reveal that although these places are public considering the ownership, their quality and characteristics as public place are diminishing day by day. Limited physical and social accessibility have narrowed the group of users who can use the public place for a variety of purposes. Another major phenomenon which can be attributed to the changing nature of public place is the growing private interest. In this backdrop, it needs planning and design considerations to make public place more inclusive to diverse groups of people as such these places can perform multiple functions in balance

PENGARUH KNOWLEDGE SHARING BEHAVIOR DAN ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) TERHADAP KINERJA KARYAWAN

Penelitian ini bertujuan untuk menguji pengaruh knowledge sharing behavior dan organizational citizenship behavior (OCB) terhadap kinerja karyawan pada ticketing officer Garuda Indonesia Branch Office Denpasar.Penelitian ini dilakukan di Garuda Indonesia Branch Office Denpasar dengan menggunakan sampel 67 orang. Data diperoleh melalui wawancara dan penyebaran kuesioner menggunakan skala Likert.Dalam penelitian ini menggunakan analisis deskriptif dengan uji regresi berganda. Hasil penelitian menyimpulkan bahwa knowledge sharing behavior dan organizational citizenship behavior (OCB) berpengaruh positif dan signifikan terhadap kinerja karyawan. Temuan dalam penelitian ini, jika dibandingkan antara knowledge sharing behavior dan organizational citizenship behavior (OCB) maka yang lebih memiliki pengaruh adalah adalah variabel knowledge sharing behavior berdasarkan atas hasil uji regresi dengan nilai yang lebih tinggi dibandingkan dengan variabel organizational citizenship behavior (OCB)