Exploring spatio-temporal wave pattern using unsupervised technique

The sea waves are the up and down movements of water in the sea. The various heights of sea waves are known as significant wave heights. Each type of wave has their own characteristics based on their significant wave heights. The aim of this research is to explore spatio-temporal wave patterns and their effects on Tok Jembal coastal areas. For this study, the monthly wave data were obtained from the satellite altimeters that have been processed using Radar Altimeter Database System (RADS). The Self Organizing Map (SOM) method was used to extract the spatio-temporal wave height patterns from the monthly wave height data. From the clustering results, six number of clusters were extracted and then each of these clusters was categorized into specific type of wave heights. In addition, time series of Landsat satellite images were used to observe the coastal changes at Tok Jembal areas. Finally, we analyzed the effects of spatio-temporal wave patterns towards the occurrences of coastal erosion along the coastal areas. This study has discovered that the wave heights along the coastal areas fall in slight category and showed less effects on the erosion. From the visual interpretation of time- series images (10 years gap) also proved that the erosion can be considered as moderate. Overall, this study could benefit the coastal management especially for shoreline monitoring where early action can be taken when there are signs of erosion along the coast

Functional implant prosthodontic score of a one-year prospective study on three different connections for single-implant restorations

Aim The aim of this prospective clinical trial was to analyze, using the Functional Implant Prosthodontic Score (FIPS), the clinical resultsof three different abutment-implant connections (1 hexagon vs 2 conical types) single-unit restorations after one year of clinical service. Material and methods Thirty patients were restored with cement-retained crowns on soft tissue level implants (10 TTc Windmix, 10 TTk Windmix and 10 Aadva GC) in posterior sites and followed-up for 1 year. FIPS was applied for objective outcome assessment beside clinical and radiographic examinations. Five variables were defined for evaluation, resulting in a maximum score of 10 per implant restoration. The patients’ level of satisfaction was recorded and correlated with FIPS. Results All implants and connected crowns revealed survival rates of 100% without any biological or technical complications after three years of loading. The total FIPS recorded for group 1 was 44, 43 in group 2 and 42 in group 3. The mean total FIPS score was 8.6±1.1, ranging from 6 to 10. The variable “bone” revealed the highest scores (2.0; range: 2–2), as well “occlusion” (2.0; range: 2–2). Mean scores for “design” (1.7 ±0.4; range: 1–2), “mucosa” (1.6±0.5; range: 1–2), and “interproximal” (1.5±0.6; range: 1–2) were more challenging to satisfy. The patients expressed a high level of functional satisfaction (80.5±2.5; range: 65–100). No type of connection showed to be superior to the other two. No statistically significant differences were found among the three tested groups. A significant correlation was found between FIPS and the subjective patients’ perception with a coefficient of 0.80 (P < 0.0001). Conclusions The findings of the clinical trial indicated the great potential of both conical and hexagon connections and their good performance after 1 year of clinical service. FIPS showed to be an objective and reliable instrument to assess implant success

Mothers' beliefs about infant teething in Enugu, South-east Nigeria: a cross sectional study

<p>Abstract</p> <p>Background</p> <p>Parents and Health Care Workers have traditionally attributed a variety of symptoms to teething in young children. Some of these symptoms may however connote underlying serious medical condition in a child. There is little evidence to support these beliefs despite their implications on management of a symptomatic teething child. This study therefore seeks determine the beliefs and problems mothers associate with teething in Enugu, South-east Nigeria.</p> <p>Findings</p> <p>A cross-sectional survey involving sixty mothers presenting at a Children's clinic in Enugu metropolis using questionnaire. More than 90% of the respondents thought that babies can experience medical problems as a result of teething. The commonest medical problems perceived to be associated with teething were fever (71.7%), loose stools (58.3%) and vomiting (35%).</p> <p>Conclusion</p> <p>Mothers still associate a variety of symptoms of childhood illnesses to teething and this association is not evidence based and could lead to delayed interventions, increased morbidity and mortality of children. It is important therefore that mothers and health workers caring for young children are educated on the need to seek prompt medical attentions in a symptomatic child.</p

Cucumeropsis mannii seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia

From Wiley via Jisc Publications RouterHistory: received 2022-12-25, rev-recd 2023-01-07, accepted 2023-02-06, pub-electronic 2023-02-18Article version: VoRPublication status: PublishedThis study demonstrated the therapeutic potentials of Cucumeropsis mannii seed oil (CMSO) capable of alleviating BPA‐induced dyslipidemia and adipokine dysfunction. In this study, we evaluated the effects of CMSO on adipokine dysfunctions and dyslipidemia in bisphenol‐A (BPA)‐induced male Wistar rats. Six‐week‐old 36 albino rats of 100–200 g weight were assigned randomly to six groups, which received varied doses of BPA and/or CMSO. The administration of BPA and CMSO was done at the same time for 42 days by oral intubation. The adipokine levels and lipid profile were measured in adipose tissue and plasma using standard methods. BPA induced significant (p < .05) increases in triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices in adipose tissue and plasma, as well as a decrease in adiponectin and HDL‐C levels in Group II animals. BPA administration significantly (p < .05) elevated Leptin levels and reduced adiponectin levels. BPA plus CMSO reduced triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices while increasing adiponectin levels and HDL‐C in adipose tissue and plasma (p < .05). The results showed that BPA exposure increased adipose tissue as well as serum levels of the atherogenic index, triglycerides, cholesterol, coronary risk index, LDL‐C, leptin, and body weight with decreased adiponectin levels and HDL‐C. Treatment with CMSO reduced the toxicities caused by BPA in rats by modulating the body weight, adiponectin/leptin levels, and lipid profiles in serum and adipose tissue. This study has shown that CMSO ameliorates BPA‐induced dyslipidemia and adipokine dysfunctions. We suggest for further clinical trial to establish the clinical applications

In Vivo and in Silico Assessment of Ameliorative Effects of Xylopia aethiopica on Testosterone Propionate-Induced Benign Prostatic Hyperplasia

Xylopia aethiopica (XAE) is a commonly used herbal medicine and contains rich active ingredients for a variety of biological activities. The study aimed to explore the role of XAE in the management of benign prostatic hyperplasia (BPH). In the study, testosterone propionate-induced BPH in albino rats was established and treated with different concentrations of ethanol extract of XAE leaf. After treatment, the rats were sacrificed, and the body and prostate weights were recorded. The prostate-specific antigen (PSA) and acid phosphatase (ACP) levels in the blood samples were also determined. Gas chromatography-mass spectrometry was conducted to assess the active chemical compounds. Docking analysis was performed to screen chemical compounds by evaluating their binding affinity with two pro-BPH protein targets (cellular prostatic ACP and PSA). Our data showed the presence of 44 chemical compounds in XAE leaf extract. The body and prostate weights, as well as the levels of PSA and ACP, were significantly increased in BPH induction, and the changing trend was significantly reversed by additional XAE treatment. Interestingly, PSA and ACP levels in XAE-treated groups were reduced to almost the same levels as those in the healthy control. Docking analysis identified four top-posed compounds: β-amyrin, α-amyrin, α-amyrenone, and lupenone with stronger binding energies to prostatic ACP being −9.8, −8.3, −8.4, and −8.6, respectively, compared with the standard drug finasteride (−8.3). Furthermore, the two-dimensional analysis revealed strong interactions through hydrogen bonding, covalent interactions, and several van der Waal forces between the lead compounds and the target proteins. Notably, there was a recurrence interaction between similar residues Asn-1062, Lys-1250, Lys-1059, and Phe-1060 on the protein targets and the lead compounds. The study first revealed the role of XAE in BPH therapy and will help in drug design based on the lead compounds discovered in this work

<i>Buchholzia coriacea</i> Leaves Attenuated Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats and Its Potential Targets <i>In Silico</i>

The study aimed to investigate how the solvent extract of Buchholzia coriacea (BCE), a widely known hypolipidemic agent, could contribute to hyperlipidemia treatment and identify the potential bioactive compounds. We studied Wistar albino rats, dividing them into seven groups: the normal control, normal rats treated with 400 mg/kg.b.wt of BCE (NRG group), the hyperlipidemic control (HPC group), hyperlipidemic rats treated with atorvastatin, a standard control drug (SC group), as well as 200, 400, and 800 mg/kg.b.wt of BCE extract respectively (T1, T2, T3 groups). The potential compounds that functioned in BCE extract were analyzed by in silico binding to acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN). The binding affinities and drug-like properties of the compounds were determined using virtual screening and absorption distribution metabolism excretion and toxicity prediction analysis. The gas chromatography-mass spectrometry analysis identified alkaloids, saponins, flavonoids, phenols, terpenoids, and 44 chemical compounds in the leaf extract of BCE. BCE significantly reduced the levels of triacylglycerol, total cholesterol, low-density lipoprotein, very low-density lipoprotein, atherogenic coefficient, atherogenic index, and coronary risk index, while enhancing the levels of high-density lipoprotein and cardioprotective index in comparison to the HPC group. The BCE reduced malondialdehyde quantities, which exhibit high levels in HPC. Superoxide dismutase and glutathione peroxidase activities as well as glutathione levels, which are otherwise reduced in HPC, were increased upon the BCE treatment. Among the identified BCE compounds, lupenone and 2,7-dimethylnaphthalene exhibited the highest binding affinities to ACC and FASN, suggesting that these two compounds might be the bioactive BCE components displaying hypolipidemic properties. BCE is found to be beneficial in blocking hyperlipidemia through the modulation of lipid profile, the protection of cardiovascular function, as well as the suppression of oxidative stress. BCE may be a natural source for exploring novel drugs for the treatment of dyslipidemia

<i>Cucumeropsis mannii</i> seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia

From Crossref journal articles via Jisc Publications RouterHistory: epub 2023-02-18, issued 2023-02-18Article version: VoRPublication status: Publishe