Exploring pre-service visual art teachers’ competitiveness through porter’s five forces model

The primary objective of this cross-sectional study was to explore the degree to which 117 pre-service visual art teachers’ competitiveness within the education field. A self-reported competitiveness scale (six items distributed between three factors) was designed and validated by the authors based on the focal points of Michael Porter’s Five Forces framework. Additionally, the   respondents’ digital competence was assessed as an auxiliary criterion of educator attractiveness in the art education domain. Both competitiveness and digital skills measurements yielded mediocre scores. Regression analysis showed that respondents’ competitiveness perceptions were predicted neither by digital skills level nor by socio-demographic characteristics such as age, gender, rural or urban background, marital status or whether the student was a graduate or undergraduate. The present study highlights the need for understanding of how visual art majors perceive the sector and   evaluate competitiveness among visual art students which itself indicates its sizable contribution to educational research. Other researchers can employ the competitiveness questionnaire introduced to gain deeper insights into the topic or related subjects

Synthesis of nitroxyl radical by direct nucleophilic functionalization of a C-H bond in the azadiene systems

Cyclic dinitrones underwent nucleophilic substitution of the hydrogen atom in the reaction with a paramagnetic carbanion, the lithium derivative of 4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazol-1-oxyl 3-oxide, to give polyfunctional nitronyl nitroxyls. © 2012 Springer Science+Business Media New York

Synthesis of chiral ferrocenylazines. Negishi cross-coupling or S N H reactions?

Preparation of new hetaryl-containing planar chiral ferrocene by a nucleophilic substitution of hydrogen in azines was performed using a lithium derivative of (S)-ferrocenyl-p-tolylsulfoxide as s nucleophilic reagent © 2013 Pleiades Publishing, Ltd

Genotype frequencies of polymorphic MDR1 variants in the Kazakhstani population

Introduction: Statins appear to be handled by an ATP-dependent membrane transporter and three SNPs (C1236T (rs1128503), G2677T (rs2032582), and C3435T (rs1045642), which capture the common genetic variation at this locus. Individuals, who carry the T allele at each SNP (i.e., the T-T-T haplotype), have higher systemic exposure to simvastatin.A triallelic thymine (T) - guanine (G) - adenine (A), which is  a point mutation at nucleotide 2677 in exon 22, leads to ABCB1 in a non-synonymous codons (GCT alanine, TCT serine, threonine ACT) at position 893 in a cytoplasmic loop of ATP-dependent membrane transporters.Methods: Blood samples from healthy individuals were collected in the Republican Diagnostic Center, Astana, Kazakhstan. The research samples included 461 healthy people. Genomic DNA was extracted from peripheral blood using the ‘salting out’ procedure. For the MDR1 exon 21, 2677G?T/A (Ala893Ser/Thr) polymorphism was genotyped by PCR sequencing by the use of dye-terminator (ABI 3730xl sequencer). Results: The GG allele appeared in 23% of samples, the GA in 6.7%, the GT in 44%, the non-G heterozygote in 4.5%, and the non-G homozygote in 18%. These results are consistent with previously published data. Importantly, the frequency of 2677T alleles in our group was 15.4%. This represents the lowest frequency of this allele compared to published data in different populations. The frequency of the 2677T allele in Asians and Caucasians varies from 38 to 62%, and is 15% for African Americans. On the other hand, the 2677A allele frequency in the Japanese varies from 15 to 22%, and in Caucasians from 2% and 4%. The 2677A allele frequency has been found in 4.6% of samples. Conclusions: Our study further emphasizes differences between various Asian populations and the importance of repeating this genetic study  in different ethnic groups

Cyclic peroxides and related initiating systems for radical polymerization of methyl methacrylate

Cyclic peroxides as initiators for the radical polymerization of methyl methacrylate were proposed. The initial rates, initiation rates, and effective activation energies of polymerization initiated by cyclic peroxides and cyclic peroxide-1-pyridyl-2-ferrocene systems were determined. The radical yields to the volume upon the thermal decomposition of cyclic peroxides and their catalytic decomposition in the presence of 1-pyridyl-2-ferrocene were determined. In combination with 1-pyridyl-2-ferrocene cyclic peroxides form efficient initiating systems favoring an increase in the polymerization rate, a decrease in the molecular weights, and an increase in syndiotacticity of the synthesized poly(methyl methacrylate). © 2013 Springer Science+Business Media New York

JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions

The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological and pathological processes such as inflammation and stress. Dysregulation in this pathway can lead to severe immunodeficiencies and malignancies, and its role extends to neurotransduction and pro-inflammatory signaling mechanisms. Although JAK inhibitors (Jakinibs) have successfully treated immunological and inflammatory disorders, their application has generally been limited to diseases with similar pathogenic features. Despite the modest expression of JAK-STAT in the CNS, it is crucial for functions in the cortex, hippocampus, and cerebellum, making it relevant in conditions like Parkinson's disease and other neuroinflammatory disorders. Furthermore, the influence of the pathway on serotonin receptors and phospholipase C has implications for stress and mood disorders. This review expands the understanding of JAK-STAT, moving beyond traditional immunological contexts to explore its role in stress-related disorders and CNS function. Recent findings, such as the effectiveness of Jakinibs in chronic conditions such as rheumatoid arthritis, expand their therapeutic applicability. Advances in isoform-specific inhibitors, including filgotinib and upadacitinib, promise greater specificity with fewer off-target effects. Combination therapies, involving Jakinibs and monoclonal antibodies, aiming to enhance therapeutic specificity and efficacy also give great hope. Overall, this review bridges the gap between basic science and clinical application, elucidating the complex influence of the JAK-STAT pathway on human health and guiding future interventions. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s).122020900136–4, FENU-2023–0014This work was funded by South Ural State University, scientific theme No. FENU-2023–0014 and partly by the theme 122020900136–4 of Institute of Immunology and Physiology

SN H Reactions of Ferrocenyllithium and Azine N-oxides

A non-catalytic C-C coupling of ferrocenyllithium and heterocyclic N-oxides 2 was carried out for the first time using the reaction of nucleophilic substitution of hydrogen (SN H) in azines. © ARKAT USA, Inc.This work was financially supported by the Russi an Foundation for Basic Research (Projects Nos 07-03-96104a and 06-03-32764), the Ministry of Science and Education (Grant for Leading Scientific Schools, Project NSh-3758.2008.3)

Synthesis of novel meso-substituted calix[4]arenes

An efficient synthetic approach for the synthesis of novel heterocyclic calix[4]arenes based on the methodology of direct C-H activation has been proposed. The method allows the bridge-functionalized azinylcalixarenes to be available.The research was financially supported by the Russian Science Foundation (Project No. 14-13-01177)

SNH Methodology in the Synthesis of Quinazolinap Precursors and Analogs

This study was financially supported by the Russian Science Foundation (Project № 14-13-01177) and the Russian Foundation for Basic Research (Projects № 16-03-00958)