The unknown consequences of COVID-19 in people with Autism Spectrum Disorders

Las alteraciones en el sistema inmunitario se encuentran a menudo en niños con trastornos del espectro autista [TEA], lo que conduce a una respuesta inmune aberrante que compromete la defensa del huésped. Menos células T reguladoras, elevación en las células inflamatorias y citoquinas proinflamatorias han sido muy reportados en esta población y se ha visto recientemente como un trastorno neuroinflamatorio crónico. Las citocinas a menudo están desreguladas en el TEA, especialmente la IL-6, que es una de las mayores preocupaciones durante la pandemia actual del COVID-19, así como otras desregulaciones inmunes. Creemos firmemente que este entorno proinflamatorio en TEA podría aumentar la vulnerabilidad de un resultado clínico pobre para la infección por COVID-19.Alterations in the immune system are often found in children with Autism Spectrum Disorders [ASD], leading to an aberrant immune response which compromises host defense. Fewer regulatory T-cells, elevation in inflammatory cells and proinflammatory cytokines have been highly reported in this population and it has been recently seen as a chronic neuroinflammatory disorder. Cytokines are often dysregulated in ASD especially IL-6, which is one of the biggest concerns during the current COVID-19 pandemic, as well as other immune dysregulations. We strongly believe that this proinflammatory environment in ASD could increase the vulnerability of a poor clinical outcome for COVID-19 infection

Speech-Stimulating Substances in Autism Spectrum Disorders

Autism spectrum disorder (ASD) is characterized by the core domains of persistent deficits in social communication and restricted-repetitive patterns of behaviors, interests, or activities. A heterogeneous and complex set of neurodevelopmental conditions are grouped in the spectrum. Pro-inflammatory events and immune system dysfunctions are cellular and molecular events associated with ASD. Several conditions co-occur with ASD: seizures, gastro-intestinal problems, attention deficit, anxiety and depression, and sleep problems. However, language and speech issues are key components of ASD symptoms current therapies find difficult to face. Several speech-stimulating substances have been shown to be effective in increasing speech ability in ASD subjects. The need for large clinical trials to determine safety and efficacy is recommended