2,223 research outputs found

    PHYTOCHEMICAL SCREENING AND ANTI-TRICHOSPORON ACTIVITY OF PLUMBAGO ZEYLANICA LINN

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    Objective: To evaluate the anti-Trichosporon activity of a medicinal plant, Plumbago zeylanica Linn and to find out the phytochemicals responsible for this activity with the use of four solvent extracts; methanol, ethanol, acetone and chloroform. Methods: To evaluate the antifungal activity, two methods were used. Agar well diffusion assay to determine the diameter of zone of inhibition (in mm) and MIC (in mg/ml) was determined through Tube dilution broth assay. Phytochemical screening for preliminary analysis of secondary metabolites was done through chemical methods. Results: Trichosporon asahii was found to be most sensitive to methanol extract of P. zeylanica with inhibition zone of 35 mm and T. inkin with 30 mm zone of inhibition. MIC results also showed that the methanol extract was most effective in lowest concentration against T. asahii with MIC at 6.2 mg/ml and inhibited T. inkin at 25 mg/ml. Phytochemical screening of plant extracts revealed the presence of certain phyto-constituents like alkaloids, steroids, flavonoids, phenols, glycosides, tannins etc. Conclusion: The present study proved the sensitivity of the yeast Trichosporon spp. to different extracts of P. zeylanica. T. asahii was found to be more sensitive towards the extracts. Methanol extract proved to be most effective compared to ethanol, acetone and chloroform as it gave the maximum zones and lowest MIC result. Phytochemical analysis proved the presence of certain phytochemicals which was responsible for their antifungal activity

    Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

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    The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum
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