No systemic reactions to influenza vaccination in egg-sensitized tertiary-care pediatric patients

<p>Abstract</p> <p>Background</p> <p>There are numerous, disparate guidelines for influenza vaccination in egg-allergic patients. We aimed to describe the outcome of selectively applied guidelines, based on risk-stratification, to our high risk, egg-allergic, tertiary-care pediatric population.</p> <p>Methods</p> <p>Egg allergy was confirmed with skin testing. The vaccine administered was an adjuvunated 2009 H1N1 influenza A vaccine with < 0.165 mcg/ml ovalbumin. Patients with mild egg allergy were to receive the vaccination in 1 dose, those with severe egg allergy were to receive 2 split doses, and patients with exquisite egg allergy or significant co-morbidities were to be skin tested with the vaccine (prick full strength, intradermal 1:100 of final concentration without adjuvant) and had 5 step desensitization if the testing was positive, or 1-2 step administration if negative. Patients were observed for 60 minutes after the final dose and anaphylaxis treatment was available. We report the frequency of allergic reactions.</p> <p>Results</p> <p>Ninety-nine patients were referred and 79 had positive egg testing. Asthma was present in 67% and 30% had prior anaphylaxis to egg. We vaccinated 77 of 79 patients: 71 without performing vaccine skin testing. Two refused vaccination. No patient had a systemic reaction or required treatment. Two patients experienced positive testing to the adjuvanated intradermal vaccine, but were negative without adjuvant.</p> <p>Conclusions</p> <p>Our results suggest that most egg-allergic tertiary care pediatric patients can be vaccinated with a low ovalbumin content influenza vaccine without prior vaccine testing. Vaccine skin testing, if used at all, can be reserved for special circumstances. The squalene adjuvant may cause an irritant reaction with intradermal testing.</p

2015

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Employee Communications

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2008-2011

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Health Minute, 2002-2007

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2012-2014

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Press Releases

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Archived Website - Survival Flight Tragedy: Condolences and Memories, 2007

To access this archived Website, download the .ZIP file and extract the contents with the utility of your choice. Using a Web browser, open the 'BHL-start-here.html' found within to review additional information from the Bentley Historical Library and follow a link to view the archived homepage.Archived version of a public condolences and memories page hosted by the Health System in the aftermath of a Survival Flight plane crash on June 4, 2007 shortly after takeoff from Milwaukee's General Mitchell International Airport. Marlin Air pilots Dennis Hoyes and Bill Serra along with David Ashburn, M.D., a fellow in cardiothoracic surgery; Richard Chenault II, a transplant donation specialist with the U-M Transplant Program; Ricky LaPensee, a transplant donation specialist with the U-M Transplant Program; and Martinus Spoor, M.D., a cardiac surgeon, were all killed as they attempted to bring a pair of lungs back to Ann Arbor for a transplant surgery.http://deepblue.lib.umich.edu/bitstream/2027.42/99566/1/Survival-Flight-Condolences.zi

University of Michigan Health System Patient Education Clearinghouse

The University of Michigan Health System Patient Education Clearinghouse includes videos, websites and handouts created by University of Michigan clinicians for patient education purposes. It also includes educational materials from other organizations that were reviewed and approved by University of Michigan clinics and committees.http://deepblue.lib.umich.edu/bitstream/2027.42/120556/1/medical_resources-university_of_michigan_health_system_patient_education_clearinghouse-February13.zi