Molekulare Mechanismen der rheumatischen Entzuendung. Teilprojekt 4: Regulation der Phospholipase A_2 bei der rheumatischen Entzuendung Abschlussbericht

Available from TIB Hannover: F98B2163+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Ultrastrukturelle Untersuchungen der Interaktionen menschlicher Blutplaettchen mit Oberflaechen von Fasern medizin-technischer Polymere: Polysulfon (PS), Polyurethan (PU) and Sepharose (S)

With 8 figs.SIGLEAvailable from TIB Hannover: D.Dt.F. QN1(4,2) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Epidemiologische, molekularbiologische und immunologische Untersuchungen zum Epstein-Barr Virus vom Subtyp B Schlussbericht

SIGLEAvailable from TIB Hannover: D.Dt.F.QN1(11,43)+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman

Longitudinalstudie zu den Auswirkungen und der Verarbeitung des unerfuellten Kinderwunsches bei Patientinnen und Patienten einer medizinisch-genetischen Beratungsstelle Abschlussbericht

Participants and aim of the study: In this study, 50 couples were investigated who requested genetic counselling at our institute because of problematic desire to have children (miscarriages without diagnosed reason, miscarriage or infant death for medical-genetical reasons, genetical disease or malformation of one of the partners, a present child or another relative). The aim of the study was to describe the coping with the counselling result, i.e., exlcusion or confirmation of a recurrence risk, as well as the resulting influences on the desire to have children, physical complaints, general satisfaction with life and partnership within an observation term of one year. Procedure: The couples attended a semi-structured interview immediately after the counselling as well as three resp. twelve months afterwards and responded to a questionnaire on their desire to have children, partnership, physical complaints and satisfaction with life. Results: During the investigation, 31 couples went through pregnancy. Thirteen couples deliberately restrained from pregnancy. Of these, only the four couples with the highest recurrence risks (25% to 50%) explained this restraint to have resulted from the unfavorable information received by genetic counselling. (orig.)Available from TIB Hannover: F97B1202 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Die beruehrungsfreie Zerkleinerung von Nierensteinen an der freigelegten Niere mit fokussierten und diffusen Stosswellen Schlussbericht. Abschlussdatum: April 1982

TIB: RN 2598 (84-055)+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Molekulare Mechanismen der rheumatischen Entzuendung Abschlussbericht

It was the aim of the investigation to analyse the molecular mechanisms, which are involved in the induction and in the perpetuation of the inflammatory process of rheumatoid arthritis and which may be used for therapeutic purposes. The title of the project was: 'Molecular mechanisms of the rheumatic inflammation'. The subheadings were: 1. Role of the oncoprotein bcl-2 synovial inflammatory processes of rheumatoid arthritis. 2. Role of growth suppressor genes in the inflammatory process of rheumatoid arthritis. 3. Role of the anti-inflammatory lipocortins in rheumatoid arthirits. 4. Regulation of the phospholipase A_2 in rheumatic inflammation. 5. Role of the cytoskeleton in the activation of neutrophil granulocytes. In project 1 the expression of bcl-2 was shown in lymphocyte subpopulations and could be correlated to the expression of apoptosis related markers. In project 2 the presence of the growth suppressor protein p53 could be demonstrated in the rheumatoid synovial membrane by western-blot analysis. In the search for autoantigens of the rheumatoid synovial membrane several antigens could be defined. In project 3 it could be shown that the expression pattern of annexin 2 could be modified by steroids and by diclofenac. Performing the mRNA-differential display technique, an upregulation of the human semaphorin E gene in rheumatoid synovial fibroblastoid cells could be detected. In project 4 it was demonstrated that following fMLP activation the release of arachidonic acid by neutrophiles is mainly mediated by the phospholipase D and the phosphatidylcholin-specific phospholipase C. In project 5 the role of the small GTPOases of the Rho-family was analysed. A correlation between the glycosylation of the GTPases and the inhibition of the actin-polymerisation was detected. (orig.)Available from TIB Hannover: DtF QN1(68,49) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Free radicals induced in solid DNA by heavy-ion bombardment

SIGLEAvailable from Gesellschaft fuer Schwerionenforschung m.b.H. (GSI), Darmstadt (DE) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Free radicals from polycrystalline pyrimidines and purines upon heavy ion bombardment at low temperatures An electron spin resonance study

The formation of free radicals in polycrystalline samples of the DNA-constituents thymine, cytosine, and adenosine after bombardment with heavy ions at about 100 K was investigated by Electron Spin Resonance (ESR) spectroscopy. Spectra were observed at 77 K after irradiation at 100 K, upon annealing up to 300 K as well as after storage at 300 K. Individual radical patterns were isolated from the spectra by comuter manipulation and assigned to structures by powder-simulations based on literature data. The spectra of thymine contain an allyl radical, the octet pattern of the 5-thymyl radical and contributions of the 6-yl radical formed by net hydrogen gain at carbon C_5.The latter species is also present in cytosine which, in addition displays the pattern due to H-addition at the carboxyl oxygen C_2. Adenosine exhibits two H-addition radicals, one at C_2, the other at C_8. Additionally, the spectra of all DNA subunits studied contain as a radical component a gaussian singlet of about 0.9 mT line width. The spectra obtained at low temperature contain already the secondary radicals but exhibit a large linewidth. This feature is attributed to dipolar coupling caused by radicals in close proximity. (orig.)SIGLEAvailable from TIB Hannover: RO 801(93-09) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Projekt: WISMED Abschlussbericht

SIGLEAvailable from TIB Hannover: RR 8420(1993,5) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman

Mukosales Immunsystem und Infektionspathogenese am Beispiel gastrointestinaler Manifestationen der HIV-Infektionen. Teilprojekt 2: Untersuchungen zur lokalen sekretorischen Immunantwort gegen HIV und andere Erreger im Gastrointestinaltrakt bei HIV-infizierten Patienten Schlussbericht

SIGLEAvailable from TIB Hannover: DtF QN1(66,46) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman