Current Care and Investigational Therapies in Achondroplasia.

The goal of this review is to evaluate the management options for achondroplasia, the most common non-lethal skeletal dysplasia. This disease is characterized by short stature and a variety of complications, some of which can be quite severe. Despite several attempts to standardize care, there is still no widely accepted consensus. This is in part due to absence of concrete data on the incidence of sudden unexplained death in infants with achondroplasia and the best investigation for ascertaining which individuals could benefit from foramen magnum decompression surgery. In this review, we identify the different options of care and management for the various orthopedic, neurologic, and respiratory complications. In parallel, several innovative or drug repositioning therapies are being investigated that would restore bone growth but may also prevent complications. Achondroplasia is the most common non-lethal skeletal dysplasia. It is characterized by short stature and a variety of complications, some of which can be quite severe. Despite several attempts to standardize care, there is still no widely accepted consensus. This is in part due to absence of concrete data on the incidence of sudden unexplained death in infants with achondroplasia and the best investigation for ascertaining which individuals could benefit from foramen magnum decompression surgery. In this review, we identify the different options of care and management for the various orthopedic, neurologic, and respiratory complications. In parallel, several innovative or drug repositioning therapies are being investigated that would restore bone growth but may also prevent complications

Sensitive VLBI Continuum and H I Absorption Observations of NGC 7674: First Scientific Observations with the Combined Array VLBA, VLA & Arecibo

We present phase-referenced VLBI observations of the radio continuum emission from, and the H I 21 cm absorption toward, the Luminous Infrared Galaxy NGC 7674. The observations were carried out at 1380 MHz using the VLBA, the phased VLA, and theArecibo radio telescope. These observations constitute the first scientific use of the Arecibo telescope in a VLBI observation with the VLBA. The high- and low-resolution radio continuum images reveal several new continuum structures in the nuclear region of this galaxy. At ~100 mas resolution, we distinguish six continuum structures extending over 1.4 arcsec, with a total flux density of 138 mJy. Only three of these structures were known previously. All these structures seem to be related to AGN activity. At the full resolution of the array, we only detect two of the six continuum structures. Both are composed of several compact components with brightness temperatures on the order of $10^{7}$ K. While it is possible that one of these compact structures could host an AGN, they could also be shock-like features formed by the interaction of the jet with compact interstellar clouds in the nuclear region of this galaxy. Complex H I absorption is detected with our VLBI array at both high and low angular resolution. Assuming that the widest H I feature is associated with a rotating H I disk or torus feeding a central AGN, we estimate an enclosed dynamical mass of ~7 x 10^7 M_sun, comparable to the value derived from the hidden broad H$\beta$ emission in this galaxy. The narrower H I lines could represent clumpy neutral hydrogen structures in the H I torus. The detection of H I absorption toward some of the continuum components, and its absence toward others, suggest an inclined H I disk or torus in the central region of NGC 7674.Comment: 37 pages, 11 figures. ApJ accepted. To appear in the Nov. 10, 2003 issue of ApJ. Please use the PDF version if the postscript doesn't show the figure

Discovery of new quasi-periodic oscillations in the X-ray transient source V~0332+53

We report the discovery of a new quasi-period oscillation (QPO) at 0.22 Hz, centered on the source spin frequency of the high mass X-ray binary system V~0332+53 when the source was observed during its November 2004/March 2005 outburst by {\em RXTE}. Besides this new QPO, we also detected the known 0.05 Hz QPO. Both the 0.22 and 0.05 Hz QPOs stand out clearly at a mid-flux level of the outburst within January 15--19 2005, and later at an even lower flux level as the width of 0.22 Hz QPO drops. No evolution of the centroid frequency with the flux is seen in either QPO. The rms value below 10 keV is around 4--6% for both QPOs and decreases at higher energies. We discuss our results in the context of current QPO models.Comment: 5 figures, 12 pages. AASTex preprint style. (In 2005, ApJ Let., 629, L33

Detailed Radio Spectra of Selected Compact Sources in the Nucleus of M82

We have determined detailed radio spectra for 26 compact sources in the starburst nucleus of M82, between 74 and 1.3 cm. Seventeen show low-frequency turnovers. One other has a thermal emission spectrum, and we identify it as an HII region. The low frequency turnovers are due to absorption by the interstellar gas in M82. New information on the AGN candidate 44.01+595, shows it to have a non-thermal falling powerlaw spectrum at the highest frequencies, and that it is strongly absorbed below 2 GHz. We derive large magnetic fields in the supernova remnants, of order 1-2 milliGauss, hence large pressures in the sources suggest that the brightest ones are either expanding or are strongly confined by a dense interstellar medium. From the largest source in our sample, we derive a supernova rate of 0.016 SN/yr.Comment: 19 pages, 7 tables, 29 figures, LaTeX, requires AAS macros v. 4.0. To appear in ApJ July 20, 199

A Dense Gas Trigger for OH Megamasers

HCN and CO line diagnostics provide new insight into the OH megamaser (OHM) phenomenon, suggesting a dense gas trigger for OHMs. We identify three physical properties that differentiate OHM hosts from other starburst galaxies: (1) OHMs have the highest mean molecular gas densities among starburst galaxies; nearly all OHM hosts have = 10^3-10^4 cm^-3 (OH line-emitting clouds likely have n(H2) > 10^4 cm^-3). (2) OHM hosts are a distinct population in the nonlinear part of the IR-CO relation. (3) OHM hosts have exceptionally high dense molecular gas fractions, L(HCN)/L(CO)>0.07, and comprise roughly half of this unusual population. OH absorbers and kilomasers generally follow the linear IR-CO relation and are uniformly distributed in dense gas fraction and L(HCN), demonstrating that OHMs are independent of OH abundance. The fraction of non-OHMs with high mean densities and high dense gas fractions constrains beaming to be a minor effect: OHM emission solid angle must exceed 2 pi steradians. Contrary to conventional wisdom, IR luminosity does not dictate OHM formation; both star formation and OHM activity are consequences of tidal density enhancements accompanying galaxy interactions. The OHM fraction in starbursts is likely due to the fraction of mergers experiencing a temporal spike in tidally driven density enhancement. OHMs are thus signposts marking the most intense, compact, and unusual modes of star formation in the local universe. Future high redshift OHM surveys can now be interpreted in a star formation and galaxy evolution context, indicating both the merging rate of galaxies and the burst contribution to star formation.Comment: 5 pages, 3 figures, 1 table, accepted by ApJ Letter

Confidential Boosting with Random Linear Classifiers for Outsourced User-generated Data

User-generated data is crucial to predictive modeling in many applications. With a web/mobile/wearable interface, a data owner can continuously record data generated by distributed users and build various predictive models from the data to improve their operations, services, and revenue. Due to the large size and evolving nature of users data, data owners may rely on public cloud service providers (Cloud) for storage and computation scalability. Exposing sensitive user-generated data and advanced analytic models to Cloud raises privacy concerns. We present a confidential learning framework, SecureBoost, for data owners that want to learn predictive models from aggregated user-generated data but offload the storage and computational burden to Cloud without having to worry about protecting the sensitive data. SecureBoost allows users to submit encrypted or randomly masked data to designated Cloud directly. Our framework utilizes random linear classifiers (RLCs) as the base classifiers in the boosting framework to dramatically simplify the design of the proposed confidential boosting protocols, yet still preserve the model quality. A Cryptographic Service Provider (CSP) is used to assist the Cloud's processing, reducing the complexity of the protocol constructions. We present two constructions of SecureBoost: HE+GC and SecSh+GC, using combinations of homomorphic encryption, garbled circuits, and random masking to achieve both security and efficiency. For a boosted model, Cloud learns only the RLCs and the CSP learns only the weights of the RLCs. Finally, the data owner collects the two parts to get the complete model. We conduct extensive experiments to understand the quality of the RLC-based boosting and the cost distribution of the constructions. Our results show that SecureBoost can efficiently learn high-quality boosting models from protected user-generated data